Rchr
J-GLOBAL ID:200901018392969521
Update date: Sep. 27, 2024
Wada Koichiro
ワダ コウイチロウ | Wada Koichiro
Affiliation and department:
Homepage URL (1):
http://www.med.shimane-u.ac.jp/pharmacology/
Research field (5):
Pharmacology
, Healthcare management, medical sociology
, Clinical pharmacy
, Physiology
, Oral medicine
Research keywords (15):
Stroke
, 癌
, 循環器疾患
, 消化器疾患
, 生活習慣病
, 炎症・免疫
, 臨床薬理学
, 薬理学
, Pharmacology
, Pathophysiology
, Gastroenterology & Pharmacology
, Clinical Pharmacology
, Dental Pharmacology
, Molecular Physiology
, Molecular Pharmacology
Research theme for competitive and other funds (33):
- 2022 - 2026 認知症発症を予測するAI画像診断の多因子拡張による認知症予防システムの開発
- 2022 - 2025 Correlationship between oral bacteria and cardiovascular diseases
- 2020 - 2023 A challenge study to establish early diagnosis method for inflammatory bowel diseases by utilizing revolutionary quantifying method for intestinal barrier function
- 2018 - 2023 ルテイン投与による還元型チオール増加を介した抗酸化能力の増強
- 2019 - 2022 A research for investigating the mechanism how highly pathogenic oral bacteria induces eosinophilic esophagitis.
- 2019 - 2022 Development of a prediction system of systemic disease using AI technology based on oral flora.
- 2017 - 2020 Clinical study of examining relation of oral bacteria and fundus bleeding
- 2016 - 2019 Effects of oral environment on lifestyle-related disease development and multimorbidity
- 2016 - 2018 Establishment of diagnostic method for leaky gut syndrome using mice model.
- 2015 - 2018 Research of the regulation of carcinoma by inhibition of nuclear receptor pathway and molecular mechanism.
- 2015 - 2018 Prediction and prevention of serious systemic diseases induced by local infection of bacteria
- 2013 - 2015 Establishment of a preadipocyte differentiation mechanism in facial area
- 2013 - 2015 Novel Therapy for CIPO
- 2012 - 2015 Inhibition of SCC proliferation and metastases with targeting aquaporin
- 2012 - 2015 Relevance of oral bacteria and ruptured cerebral aneurysm
- 2012 - 2014 Role of oral bacteria on hepatitis
- 2011 - 2012 Challenging research for elucidating the role of oral bacteria in the pathogenesis of IBD
- 2010 - 2011 Periodontal bacteria as one of the risk factors for developing of Non-alcoholic steato-hepatitis(NASH)
- 2009 - 2011 Role of Mcl-1 expression on tumor cell growth and metastasis
- 2008 - 2010 Investigation for apoptosis regulation system of Monad and its application on therapy of oral tumors
- 2006 - 2008 Role of PPAR-mediated pathway on induction of anoikis in squamous cell carcinoma
- 2006 - 2007 口腔形成制御に繋がる新規カルシウム結合タンパク質の同定と解明
- 2003 - 2004 Effects of PPARγ and its mew on the development of central nervous system.
- 2002 - 2004 Effect of protein nitration on peri-gingivitis and inflammatory regulation mechanism involving nitration and de-nitration.
- 2000 - 2001 Direct and indirect effects of nitric oxide on nociceptive signal transduction at the trigeminal nucleus caudalis and mechanism for the regulation
- 1995 - 1995 生体内スーパーオキサイドラジカルの高感度測定系の開発とその病態モデルへの応用
- Study on Regulation of Inflammation by Protein Nitration
- Gene Therapy for Inflammation and Ischemia-Reperfusion Injury.
- Study on Transcription Factor in Inflammation.
- Leaky gut syndrome の病態解明と全身疾患発症との関連性
- 重度全身疾患誘発性口腔細菌に関する研究
- 炎症・免疫系におけるマイクロRNAの役割に関する研究
- 非アルコール性脂肪肝炎発症メカニズムの解明と治療薬の開発
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Papers (189):
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岡本 貴行, 勝部 由貴子, 服部 舞, 臼田 春樹, 太田 淳一, 二階 哲朗, 和田 孝一郎. トロンボモジュリンは血管内皮細胞のホルネリンと相互作用して血管新生を調節する. 日本血栓止血学会誌. 2024. 35. 2. 359-359
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森田 祐介, 臼田 春樹, 渡邊 伸英, 田邊 淳也, 山崎 誠太, 安田 優, 川原 洋, 香川 雄三, 佐藤 寛大, 公受 伸之, et al. Oral Microbiome Composition and Presence of Pathogenic Bacteria in Patients with Cardiovascular Disease(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ125-2
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Michihiro Iwaki, Takaomi Kessoku, Kosuke Tanaka, Anna Ozaki, Yuki Kasai, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, et al. Combined, elobixibat, and colestyramine reduced cholesterol toxicity in a mouse model of metabolic dysfunction-associated steatotic liver disease. Hepatology communications. 2023. 7. 11
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Ryosuke Tanino, Yukari Tsubata, Takamasa Hotta, Tamio Okimoto, Yoshihiro Amano, Mayumi Takechi, Tetsuya Tanaka, Tomomi Akita, Mamiko Nagase, Chikamasa Yamashita, et al. Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs. Scientific reports. 2023. 13. 1. 10740-10740
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Usuda Haruki, Niibayashi Tomomi, Morita Yusuke, Endo Akihiro, Okamoto Takayuki, Tanabe Kazuaki, Wada Koichiro. Patients with cardiovascular diseases exhibit distinct characteristics in their oral microbiome and are more susceptible to infections by pathogenic bacteria. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023. 97. 3-B-P-046
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MISC (189):
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岡本貴行, 臼田春樹, 和田孝一郎. 血管内皮細胞の硬さとギャップ結合におけるYAPの役割. 日本薬理学雑誌. 2023. 158. Supplement
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臼田春樹, 新林友美, 岡本貴行, 和田孝一郎. 好酸球性食道炎患者における高病原性口腔内細菌の保菌および口腔内細菌叢についての基礎的検討. 日本薬理学雑誌. 2022. 157. Supplement
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JAHAN Israt, OKAMOTO Takayuki, USUDA Haruki, TANAKA Tetsuya, NIIBAYASHI Tomomi, NAKAJIMA Atsushi, WADA Koichiro. MiR-126-3p and MiR-199a-3p Promote Lipid Accumulation in 3T3-L1 Adipocytes via Regulating HIF-1α and C/EBPα Expression. Shimane Journal of Medical Science (Web). 2022. 39. 4
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USUDA Haruki, KANDA Syoma, OKAMOTO Takayuki, WADA Koichiro. Lacking dietary fiber enhances sensitivity to inflammatory stimuli, that results in intestinal hyper-permeability. 日本薬理学会年会(Web). 2021. 94th
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吉原努, 日暮琢磨, 高津智弘, 三澤昇, 芦苅圭一, 松浦哲也, 冬木晶子, 大久保秀則, 馬場隼一, 來生知, et al. Treatment of periodontal disease reduces Fusobacterium nucleatum in feces. 日本消化管学会雑誌. 2021. 5. Supplement
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Patents (2):
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腸粘膜の透過性の診断薬、診断方法、診断装置
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Pharmaco-PICOS
Books (2):
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プリンシプル消化器疾患の臨床1 食道・胃・十二指腸の診療アップデート
株式会社 中山書店 2017 ISBN:9784521744421
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腸内細菌・口腔細菌と全身疾患
シーエムシー出版 2015 ISBN:9784781311395
Lectures and oral presentations (23):
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腸粘膜バリアの機能低下を評価する新規試薬の開発
(第3回 黒潮カンファレンス異分野融合創薬研究会 2018)
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in situ RT-PCR 法を用いた mmcp-4 発現マスト細胞の組織学的検出
(第3回 黒潮カンファレンス異分野融合創薬研究会 2018)
-
NAFLDと腸内細菌.
(第3回 黒潮カンファレンス異分野融合創薬研究会 2018)
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血栓形成における血管内皮細胞の硬さの役割
(第3回 黒潮カンファレンス異分野融合創薬研究会 2018)
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Role of dietary habit on the composition of oral bioflora and its relevance to systemic diseases: Oral bacteria may be involved in the health life expectancy?
(第18回 ダノン健康栄養財団カンファランス 2018)
more...
Education (1):
- - 1994 Hamamatsu University School of Medicine Graduate School, Division of Medicine
Professional career (1):
- Ph.D. (Hamamatsu University School of Medicine)
Work history (5):
- 1998 - 2000 Harvard Medical School, Research Fellow
- 2000 - Boston University School of Medicine, Visiting Professor
- 1997 - 1998 University of Texas Medical School, Research Fellow
- 1994 - 1998 Tottori University, Faculty of Medicine, Research Associate
- 1994 - ~鳥取大学医学部 助手1995~鳥取大学医学部 学内講師1997~テキサス大学医学部 研究員1998~ハーバード大学医学部 研究員2000~ボストン大学医学部消化器内科 客員教授兼 Faculty Staff2000~大阪大学大学院歯学研究科 講師2006~大阪大学大学院歯学研究科 助教授/准教授
Committee career (5):
- 2020/12 - 現在 日本臨床薬理学会 海外研修員制度委員会 委員長
- 2019 - 2020 日本臨床薬理学会 リエゾン委員
- 2018 - 2020 黒潮カンファレンス異分野融合創薬研究会 副理事長
- 2018 - 2020 日本臨床薬理学会 理事
- 2017 - 2019 日本薬理学会 代議員
Association Membership(s) (6):
American Society for Biochemistry and Molecular Biology
, 日本消化吸収学会
, 日本毒性学会
, 日本薬理学会
, 黒潮カンファレンス異分野融合創薬研究会
, 日本臨床薬理学会
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