Rchr
J-GLOBAL ID：200901018828563712   Update date: Oct. 02, 2024

Kobashigawa Yoshihiro

コバシガワ ヨシヒロ | Kobashigawa Yoshihiro
Homepage URL  (1)： http://www.pharm.kumamoto-u.ac.jp/Labs/bunseki/
Research field  (2)： Biophysics ,  Structural biochemistry
Research keywords  (10)： nuclear receptor ,  tyrosine kinase inhibitor ,  NMR ,  薬剤耐性変異体 ,  チロシンキナーゼ ,  シグナル伝達 ,  Antibody Engineering ,  Protein Engineering ,  structural biology ,  Protein Folding
Research theme for competitive and other funds  (14)：
  • 2024 - 2027 Elucidation of Tyrosine Kinase Inhibitor Drug Selectivity Based on Structural Biology, Biophysical Chemistry, and Computational Chemistry
  • 2022 - 2025 多彩な構造を有する天然物の迅速評価による核内受容体の活性化・阻害と構造の相関解析
  • 2021 - 2024 抗がん剤耐性克服へ向けた核内受容体の活性制御機構の解明
  • 2018 - 2021 Elucidation of the molecular mechanism underlying TTR monomer unfolding and aggregate formation and its application to therapeutic approaches for FAP
  • 2018 - 2021 Production of peptide that associate to the dimer interface of kinase domains
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Papers (61)：
  • Yuka Nakamura, Hiroshi Watanabe, Teruya Nakamura, Mami Chirifu, Kana Ishiodori, Tadashi Imafuku, Hitoshi Maeda, Yoshihiro Kobashigawa, Hiroshi Morioka, Toru Maruyama. Contribution of Phe112, Ser114, and Tyr115 to Drug-Binding Selectivity in the A Variant of α1-Acid Glycoprotein. Molecular Pharmaceutics. 2024
  • Sena Kamesawa, Mizuki Ogawa, Yoshiki Funakoshi, Masaya Kato, Shosei Kai, Mana Namikawa, Kyo Okazaki, Takashi Sato, Yoshihiro Kobashigawa, Hiroshi Morioka. Evaluation of the cyclic single-chain Fv antibody derived from nivolumab by biophysical analyses and in vitro cell-based bioassay. Journal of biochemistry. 2024
  • Yan Du, Yoshihiro Kobashigawa, Kyo Okazaki, Mizuki Ogawa, Tomoyuki Kawaguchi, Takashi Sato, Hiroshi Morioka. Structure-based design, biophysical characterization, and biochemical application of the heterodimeric affinity purification tag based on the Schistosoma japonicum glutathione-S-transferase (SjGST) homodimer. The Journal of Biochemistry. 2024
  • Yuki Inada, Yuichiro Ono, Kyo Okazaki, Takuma Yamashita, Tomoyuki Kawaguchi, Shingo Kawano, Yoshihiro Kobashigawa, Shoko Shinya, Chojiro Kojima, Tsuyoshi Shuto, et al. Hydrogen bonds connecting the N-terminal region and the DE loop stabilize the monomeric structure of transthyretin. Journal of biochemistry. 2023. 174. 4. 355-370
  • Kyo Okazaki, Yoshihiro Kobashigawa, Hikari Morita, Soichiro Yamauchi, Natsuki Fukuda, Chenjiang Liu, Yuya Toyota, Takashi Sato, Hiroshi Morioka. Molecular Dynamics-Based Design and Biophysical Evaluation of Thermostable Single-Chain Fv Antibody Mutants Derived from Pharmaceutical Antibodies. ACS Omega. 2023
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MISC (1)：
  • 森岡 弘志, 小橋川 敬博, 諏訪 喜昭, 山下 駿, 山本 珠実, 福田 夏希, 二階堂 里那, 中原 悠介, 龍野 友花, 斉藤 貴士, et al. 創薬研究の基盤となる相互作用解析 一本鎖抗体の実用化に向けた構造機能解析. 日本薬学会年会要旨集. 2014. 134年会. 1. 242-242
Patents (11)：
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Books (3)：
  • パートナー分析化学II
    南江堂 2021 ISBN:9784524403844
  • アップデート薬学機器分析学
    廣川書店 2020 ISBN:9784567258104
  • ペプチド医薬品のスクリーニング・安定化・製剤化技術
    技術情報協会 2017
Education (2)：
  • - 2002 Hokkaido University
  • - 1999 Hokkaido University Graduate School, Division of Natural Science
Professional career (1)：
  • (BLANK) (Hokkaido University)
Association Membership(s) (3)：
PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN
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