Rchr
J-GLOBAL ID：200901019384147225   Update date: Jan. 30, 2024

Takiguchi Masufumi

タキグチ マスフミ | Takiguchi Masufumi
Affiliation and department：
Hiroshima International University Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences

About Hiroshima International University Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences


Job title： Professor
Homepage URL  (1)： http://www.hirokoku.jp/yy/TopPage/index.html
Research field  (1)： Pharmaceuticals - health and biochemistry
Research keywords  (2)： 毒性学 ,  Toxicology
Research theme for competitive and other funds  (10)：
  • 2010 - 2014 Anti-carcinogenic effects of zinc by induction of apoptosis and inhibition of DNA methylation
  • 2007 - 2009 The role of DNA methylation in cadmium-induced anti-carcinogenesis
  • 2005 - 2006 重金属やストレス環境で誘導されるメタロチオネインのガン悪性化機構における役割
  • 2003 - 2004 環境汚染物質カドミウムのDNAメチル化異常による発ガン機構
  • ストレスと生体内重金属
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Papers (22)：
  • Masayo Hirao-Suzuki, Koki Kanameda, Masufumi Takiguchi, Narumi Sugihara, Shuso Takeda. 2-Methoxyestradiol as an Antiproliferative Agent for Long-Term Estrogen-Deprived Breast Cancer Cells. Current issues in molecular biology. 2023. 45. 9. 7336-7351
  • Masayo Hirao-Suzuki, Masufumi Takiguchi, Shin'ichi Yoshihara, Shuso Takeda. Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) accelerates ligand-independent activation of estrogen receptors in long-term estradiol-deprived MCF-7 cells. Toxicology letters. 2023. 378. 31-38
  • Masayo Hirao-Suzuki, Koga Takayuki, Masufumi Takiguchi, Jeffrey M. Peters, Shuso Takeda. Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells. Archives of Biochemistry and Biophysics. 2022. 731. 109428-109428
  • Genki Sakai, Masayo Hirao-Suzuki, Takayuki Koga, Takananobu Kobayashi, Jun Kamishikiryo, Michitaka Tanaka, Kiyonaga Fujii, Masufumi Takiguchi, Narumi Sugihara, Akihisa Toda, et al. Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated cell migration. The Journal of toxicological sciences. 2022. 47. 4. 159-168
  • Shuso Takeda, Masayo Hirao-Suzuki, Yukimasa Yamagishi, Takahiro Sugihara, Masataka Kaneko, Genki Sakai, Tetsuya Nakamura, Yuhzo Hieda, Masufumi Takiguchi, Masahiro Okada, et al. Effects of the ethanol extract of Neopyropia yezoensis, cultivated in the Seto Inland Sea (Setonaikai), on the viability of 10 human cancer cells including endocrine therapy-resistant breast cancer cells. Fundamental Toxicological Sciences. 2021. 8. 3. 75-80
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MISC (37)：
  • 平尾雅代, 境絃樹, 古賀貴之, 田中満崇, 杉原成美, 瀧口益史, 竹田修三. PPARα-mediated regulation mechanisms of fatty acid 2-hydroxylase (FA2H) expression in MDA-MB-231 cells. 日本薬学会年会要旨集(Web). 2022. 142nd
  • 平尾雅代, 古賀貴之, 境絃樹, 瀧口益史, 戸田晶久, 杉原成美, 竹田修三. Cannabidiolic acid mediated-down-regulation of COX-2 expression through the abrogation of PPARβ/δ signaling. Journal of Toxicological Sciences. 2021. 46. Supplement
  • 境絃樹, 平尾雅代, 古賀貴之, 瀧口益史, 杉原成美, 竹田修三. Perfluorooctanoic acid stimulates breast cancer cell migration depending on the PPARα-FA2H axis. 衛生薬学・環境トキシコロジー講演要旨集. 2021. 2021
  • 平尾雅代, 境絃樹, 田中満崇, 杉原成美, 瀧口益史, 竹田修三. Repeated exposure to MBP, an active metabolite of bisphenol A, stimulates breast cancer cell proliferation through ERβ activation. 衛生薬学・環境トキシコロジー講演要旨集. 2021. 2021
  • 平尾雅代, 古賀貴之, 境絃樹, 境絃樹, 瀧口益史, 戸田晶久, 杉原成美, 竹田修三, 竹田修三. Cannabidiolic acid down-regulates COX-2 expression through abrogating PPARβ/δ function. 日本薬学会年会要旨集(Web). 2021. 141st
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Books (7)：
  • 予防薬学としての衛生薬学 : 健康と環境
    廣川書店 2022 ISBN:9784567472036
  • コンパス衛生薬学 : 健康と環境
    南江堂 2020 ISBN:9784524403714
  • 食品の安全
    南江堂 2018 ISBN:9784524245321
  • 予防薬学としての衛生薬学 : 健康と環境
    廣川書店 2016 ISBN:9784567472029
  • 衛生薬学 : 健康と環境
    東京化学同人 2016 ISBN:9784807917112
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Education (4)：
  • - 1996 Nagasaki University
  • - 1996 Nagasaki University Graduate School, Division of Pharmaceutical Sciences
  • - 1991 Fukuoka University Faculty of Pharmaceutical Sciences Department of Pharmaceutics
  • - 1991 Fukuoka University Faculty of Pharmaceutical Science
Professional career (1)：
  • Doctor of Philosophy. (Nagasaki University)
Work history (6)：
  • 2013 - 現在 Hiroshima International University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Professor
  • 2004 - 2013 Hiroshima International University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Associate Professor
  • 2000 - 2004 Tokushima Bunri University Faculty of Pharmaceutical Sciences
  • 2000 - 米国国立ガン研究所, 日本学術振興会 特別研究員
  • 1997 - 1999 米国国立環境保健科学研究所内米国国立ガン研究所 博士研究員
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Committee career (5)：
  • 2021/02 - 現在 日本薬学会代議員
  • 2020/02 - 現在 日本薬学会中国四国支部 支部幹事
  • 2018/06 - 現在 呉市廃棄物審議会委員
  • 2022/02 - 2023/01 日本薬学会中国四国支部 庶務担当幹事
  • 2012/11 - 2020/11 広島大学ヒトゲノム・遺伝子解析研究倫理審査委員会 広島大学ヒトゲノム・遺伝子解析研究倫理審査委員会実地調査担当者
Awards (4)：
  • 2023/05 - 日本毒性学会 ファイザー賞
  • 2021/05 - ファイザー賞 Bisphenol AF as an activator of human estrogen receptor β1 (ERβ1) in breast cancer cell lines
  • 1999 - 米国毒科学会金属部門ポスドク賞(Society of Toxicology, Metal Special Section Postdoctral Student award)
  • 1999 - Society of Toxicolgy, Metal Special Section Post-Doc Award
Association Membership(s) (4)：
Society of Toxicology ,  日本微量元素学会 ,  日本薬学会 ,  日本毒性学会
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