Ono Minoru

• 東大病院医工連携部  部長

• 2023 - 2027 Optimizing biocompatibilities of an artificial lung in a setting of a long-term pulmonary artery-left atrium (PA-LA) extracorporeal circulation system
• 2022 - 2025 植込型補助人工心臓患者における血栓・出血合併症の新予測システム確立に関する研究
• 2022 - 2025 心内膜の線維化に着眼した心線維化メカニズムの解明とその治療法の開発
• 2019 - 2023 心内膜の線維化に着眼した心線維化メカニズムの解明とその治療法の開発
• 2015 - 2018 Lanthanum carbonate inhibits aortic allograft calcification in circulatory transplant models
2014 - 2018 Comprehensive study for practical use of a total implantable total artificial heart with small size and high performance.
2013 - 2015 結紮を必要としない微細縫合糸の開発に関する前臨床試験
2010 - 2015 Clinical Trial of Berlin Heart Excor Pediatric
2010 - 2014 Comprehensive study of an implantable total artificial heart using continuous flow blood pump
2011 - 2013 Animal implant research on small suturing device which eliminates knot tying
2011 - 2013 Phosphate binders inhibit calcification of aortic and cardiac valve allografts.
2010 - 2012 慢性虚血性心疾患に対する在宅体外式カウンターパルセーション治療の有効性の検討
2008 - 2012 手術用ロボットシステムの開発と臨床応用
2009 - 2011 Construction of the heart rehabilitation system by the assisted artificial heart which aimed at the cardiac functional recovery of serious heart failure
2005 - 2008 Basic study for implantable non-pulsatile total artificial heart
2004 - 2005 臍帯血幹細胞移植を用いた再生医療的技術による心筋梗塞治療法の開発
2002 - 2004 Clinical and experimental research on prolongation of durability of cryopreserved allogeneic heart valve and vessel
2002 - 2004 Development of prosthetic valve with self expanding suture seat.
1999 - 2001 Development of auto-swelling vascular grafts using superabsorbent polymer
1999 - 2001 Newly developed auto-swelling vascular grafts for endovascular repair
1998 - 1999 Studies on the cellular modulation in cryopreservation focusing the allogenicity of thoracic tissues
1997 - 1999 Studies on the implantation of the heart valves or great vessels utilizing viable xeno-tissues
1997 - 1998 胸腺腫のリンパ球誘導・分化阻害機構の基礎的研究
1997 - 1998 凍結保存が血管内皮細胞の抗原性に及ぼす影響についての基礎的研究
1997 - 1998 Basic and Clinical study on Percutaneous Endovascular Surgery With Ultrathin-wall Vascular Grafts
1994 - 1996 Development of the new monitoring system for acute rejection in clinicallung and lung-heart transplantation, focusing on the cytotoxicity specific to the major histocompatibility complex class I antigens of the donor organ.
1995 - 1995 同種肺移植拒絶反応における臓器特異的抗原の基礎的研究
1994 - 1995 RESEARCH ON HUMAN AIRWAY EPITHELIUM ACTING AS ALLOANTIGEN-PRESENTING CELLS
補助人工心臓離脱を可能とするために臨床研究
同種弁・血管の長期生着率向上に関する研究
Clinical reaserch on weaning from left ventricular assist device after long-term support
Development and clinical application of robotic system to cardiac surgery
Development of minute suture which eliminates ligature

• Hiroki Yagi, Hiroshi Akazawa, Qing Liu, Kimiko Yamamoto, Kan Nawata, Akiko Saga-Kamo, Masahiko Umei, Hiroshi Kadowaki, Ryo Matsuoka, Akito Shindo, et al. XOR-Derived ROS in Tie2-Lineage Cells Including Endothelial Cells Promotes Aortic Aneurysm Progression in Marfan Syndrome. Arteriosclerosis, thrombosis, and vascular biology. 2025
• Takashi Hiruma, Shunsuke Inoue, Toshiyuki Ko, Seitaro Nomura, Ryo Abe, Chie Bujo, Junichi Ishida, Norifumi Takeda, Eisuke Amiya, Masaru Hatano, et al. PRKAG2 Syndrome Caused by a Novel Missense Variant Mimicked Sporadic Hypertrophic Cardiomyopathy Until Its Progression to Burned-Out Phase. Circulation. Heart failure. 2024. e012047
• Shinya Yamamoto, Koh Okamoto, Hiraku Kumamaru, Makoto Saito, Hiroshi Ito, Marie Yamashita, Yoshiaki Kanno, Mahoko Ikeda, Sohei Harada, Shu Okugwa, et al. Clinical impact of the use of chronic suppressive antibiotics against recurrent ventricular assist device infections. Microbiology spectrum. 2024. e0039824
• Takashi Nishimura, Yasutaka Hirata, Takayuki Ise, Hiroyuki Iwano, Hironori Izutani, Koichiro Kinugawa, Takeshi Kitai, Takayuki Ohno, Tomohito Ohtani, Takahiro Okumura, et al. JCS/JSCVS/JCC/CVIT 2023 guideline focused update on indication and operation of PCPS/ECMO/IMPELLA. Journal of cardiology. 2024. 84. 3. 208-238
• Taizo Hibi, Hiroyuki Yamamoto, Takahiro Miyoshi, Norihiko Ikeda, Akinobu Taketomi, Minoru Ono, Masakazu Toi, Hisato Hara, Hiroaki Nagano, Yuko Kitagawa, et al. Impact of the coronavirus disease 2019 pandemic on 20 representative surgical procedures in Japan based on the National Clinical Database: annual surveillance of 2021 by the Japan Surgical Society. Surgery today. 2024. 54. 7. 751-762

ｍore...

• 縄田 寛, 吉岡 大輔, 小野 稔, 秋山 正年, 澤 芳樹, 齋木 佳克, 中川 健, 江川 裕人. 心臓臓器移植におけるAMR治療の実態とrituximab(遺伝子組換え)使用に関する全国使用実態調査の結果. 移植. 2021. 56. 1. 43-52
• 山崎健二, 胡盛寿, 董念国, 陳良万, 本村禎, SLAUGHTER Mark, 小野稔, 齋木佳克, 戸田宏一, 齋藤聡, et al. 国産植込型補助人工心臓EVAHEARTの海外展開. 北海道外科雑誌. 2020. 65. 1
• 山崎健二, 本村禎, 胡盛寿, 董念国, 陳良万, SLAUGHTER Mark, 小野稔, 齋木佳克, 戸田宏一, 齋藤聡, et al. 国産植込型補助人工心臓EVAHEARTの中国・米国展開. 人工臓器(日本人工臓器学会). 2020. 49. 2
• 後藤博志, 松浦勝久, 関根秀一, 小前兵衛, 山崎祐, 佐々木大輔, 本間順, 小野稔, 清水達也. ヒトiPS細胞由来心筋組織の成熟における,収縮・弛緩能の向上とその維持. 日本再生医療学会総会(Web). 2020. 19th
• Hiroshi Goto, Katsuhisa Matsuura, Hidekazu Sekine, Hyoe Komae, Yu Yamasaki, Daisuke Sasaki, Minoru Ono, Tatsuya Shimizu. Improvement of Relaxation Function is a Novel Index of Maturation in Human Induced Pluripotent Stem Cell-Derived Engineered Cardiomyocyte Tissues. CIRCULATION. 2019. 140

ｍore...

• - 1987 The University of Tokyo Faculty of Medicine
• - 1987 The University of Tokyo Faculty of Medicine School of Medicine

• PhD (The University of Tokyo)

• 2021/11 - 現在 International Federation for Artificial Organs Executive Board Member
• 2019/04 - 現在 Japan Biodesign President
• 2019/02 - 現在 Asian Society for Thoracic and Cardiovascular Surgery Secretary General, Executive Board Member
• 2013/10 - 現在 Japanese College of Angiology Executive Board member, Councilor
• 2012/04 - 現在 Japanese Heart Failure Society Executive Board member, Councilor
2012/02 - 現在 Japan Surgical Society Executive Board member, Councilor
2011/09 - 現在 Japanese Society for Transplantation President, Executive Board member, Councilor
2011/03 - 現在 Japanese Society for Circulation Board of Directors, Councilor
2010/10 - 現在 Japanese Association for Computer Assisted Surgery Executive board member, Councilor
2010/09 - 現在 Japanese College of Cardilogy Executive Board member, Councilor, FJCC
2010/04 - 現在 Japanese Association for Thoracic Surgery Executive Board member, Councilor
2010/01 - 現在 Japanese Society for Cardiovascular Surgery Executive board member, Councilor, Editor
2009/11 - 現在 Japanese Society for Artificial Organs Vice President, Councilor
2017/10 - 2018/10 国際機械的循環補助学会 President

European Society for Cardio-Thoracic Surgery ,  Society of Thoracic Surgeons ,  American Association for Thoracic Surgery ,  International Society for Mechanical Circulatory Support ,  International Society of Heart and Lung Transplantation ,  JAPANESE ASSOCIATION FOR CORONARY ARTERY SURGERY ,  JAPANESE HEART FAILURE SOCIETY ,  Japanese Association for Computer Assisted Surgery ,  The Asian Society for Cardiovascular and Thoracic Surgery ,  The transplantation Society ,  日本組織移植学会 ,  日本移植学会 ,  日本内視鏡外科学会 ,  日本人工臓器学会 ,  日本心臓病学会 ,  日本循環器学会 ,  日本心臓血管外科学会 ,  日本胸部外科学会 ,  日本外科学会