Rchr

J-GLOBAL ID：200901019784388086 Update date: Sep. 26, 2024

Horiguchi Yasuhiko

ホリグチヤスヒコ | Horiguchi Yasuhiko

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://bactox1.biken.osaka-u.ac.jp/

Research field (2)： Bacteriology , Cell biology

Research keywords (2)：細胞生物学 , Cell Biology

Research theme for competitive and other funds (33)：

2023 - 2026 The mechanism of Bordetella parapertussis-induced paroxysmal coughing
2021 - 2023 百日咳菌の病原性発現制御系を利用した新たな感染防御法の探索
2020 - 2023 The mechanism of paroxysmal cough in pertussis
2018 - 2022 Construction of chimeric bacteria and analysis of host specificity determination mechanism of pathogenic bacteria
2017 - 2020 The growth-down of Mycobacterium tuberculosis by macrophages-derived extracellular vesicles

2017 - 2020 Study on the mechanism of paroxysmal coughing seen in pertussis

2016 - 2018 Preparation of Bordetella pertussis that infects experimental animals by introduction of large DNA fragments from B. bronchiseptica

2014 - 2017 Analyses for the mechanism by which Bordetella pertussis causes paroxysmal coughing

2013 - 2015 Development of Bordetella pertussis that infects experimental animals

2011 - 2014 Basic analysis of pathogenesis of whooping cough

2011 - 2012 Development of a novel technique to monitor gene expression profiles of pathogenic bacteria during infection process

2006 - 2011 Matrix of Infection Phenomena

2008 - 2010 Study on factors that determine the host specificity of Bordetella pertussis infection.

2006 - 2010 The structure-function relationship of the dermonecrosis-inducing toxins and their roles in the bacterial infections.

2005 - 2006 百日咳菌の特異的なヒト感染性を規定する因子の検索

2004 - 2005 腸管病原性大腸菌の感染初期過程における腸上皮バリア破壊メカニズムの解析

2003 - 2004 Role of Bordetella pertussis virulence factors in pathogenesis of whooping cough.

2000 - 2004 Mechanism of the paracellular molecular transport

2002 - 2003 Ebaluation of the efficacy of single chain recombinant antibody fragments derived from an anti-tetanus human monoclonal antibody with high toxin-neutralizing activity as a model

2002 - 2002 百日咳菌における病原因子の作用機構の解析

2001 - 2002 Attempts for identification of a cell receptor for Bordetella dermonecrotic toxin and localization of its functional domains

2001 - 2001 百日咳発症におけるタンパク性毒素の役割の解析

1999 - 2000 Identification of a cell surface receptor for Bordetella dermonecrotic *

1997 - 1998 Pasteurella multocidaが産生する毒素の細胞内標的分子の同定

1996 - 1997 Analysis of physiological functions of target proteins of tetanus and diphtheria toxins using complexes of homologous fragments of the toxins

1996 - 1996 Bordetella壊死毒の機能ドメインの解析

1995 - 1996 Studies on the application of anti-tetanus human monoclonal antibodies having high neutralizing activity to use in place of current polyclonal tetanus antitoxin preparations.

1995 - 1995 Bordetella壊死毒の分子レベルの作用機構の解析

1993 - 1993 Bordetella壊死毒の骨芽細胞分化阻害作用機構の解明

1992 - 1993 活性毒素フラグメント〔A〕を用いた破傷風毒素の神経伝達阻害作用の分子機構の解明

1992 - 1993 活性毒素フラグメント[A]を用いた破傷風毒素の神経伝達阻害作用の分子機構解明

細菌毒素の構造と機能

Structure and function of bacterial toxins

Show all

Papers (118)：

Sakura Tsutamoto, Yuina Iwasaki, Akari Shinohara, Risa Imamiya, Keiichi Samukawa, Miki Kawada-Matsuo, Hitoshi Komatsuzawa, Yui Yamada, Kouki Mandokoro, Hiroshi Iwao, et al. Triterpenoid saponin from Panax ginseng increases the sensitivity of methicillin-resistant Staphylococcus aureus to β-lactam and aminoglycoside antibiotics. Microbiology spectrum. 2024. 12. 6. e0322723
Yasuhiko Horiguchi. Current understanding of Bordetella-induced cough. Microbiology and immunology. 2024. 68. 4. 123-129
Xingyan Ma, Dendi K Nugraha, Yukihiro Hiramatsu, Yasuhiko Horiguchi. RpoN (sigma factor 54) contributes to bacterial fitness during tracheal colonization of Bordetella bronchiseptica. Microbiology and immunology. 2024. 68. 2. 36-46
Dianita S Saputri, Hendra S Ismanto, Dendi K Nugraha, Zichang Xu, Yasuhiko Horiguchi, Shuhei Sakakibara, Daron M Standley. Deciphering the antigen specificities of antibodies by clustering their complementarity determining region sequences. mSystems. 2023. 8. 6. e0072223
Yukihiro Hiramatsu, Takashi Nishida, Natsuko Ota, Yuki Tamaki, Dendi K Nugraha, Yasuhiko Horiguchi. DAT, deacylating autotransporter toxin, from Bordetella parapertussis demyristoylates Gαi GTPases and contributes to cough. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 40. e2308260120

ｍore...

MISC (87)：

平松征洋, 鈴木孝一朗, 西田隆司, 堀口安彦. マウス咳発症モデルを用いた百日咳の咳発作発症機構の解明. 日本細菌学雑誌. 2021. 76. 1. 17-17
平松征洋, 鈴木孝一朗, 西田隆司, 堀口安彦, 堀口安彦. 百日咳の咳発作はリポオリゴサッカライド,Vag8,百日咳毒素の協調作用によって起こる. トキシンシンポジウム予稿集. 2021. 67th
牛丸裕貴, 平松征洋, 前田育男, 藤井翔太, 田中晃司, 宮崎安弘, 牧野知紀, 高橋剛, 黒川幸典, 山崎誠, et al. 医療用綿製品から溶出するコットン・パーティクルの感染制御学的意義. 2019
岡真優子, 今宮理沙, 市川寛, 南山幸子, 堀口安彦. 生態,生理・構造,遺伝・ゲノミクス・バイオテクノロジー大腸菌とマクロファージの細胞外小胞を介した相互作用による炎症因子の誘導機構(The extracellular vesicles from E. coli and macrophages mediate the inflammatory responses). 日本細菌学雑誌. 2019. 74. 1. 38-38
岡真優子, 今宮理沙, 市川寛, 南山幸子, 堀口安彦. 生態,生理・構造,遺伝・ゲノミクス・バイオテクノロジー大腸菌とマクロファージの細胞外小胞を介した相互作用による炎症因子の誘導機構(The extracellular vesicles from E. coli and macrophages mediate the inflammatory responses). 日本細菌学雑誌. 2019. 74. 1. 38-38

ｍore...

Books (2)：

"Toxin receptors" in The comprehensive Sourcebook of Bacterial Protein Toxins
Academic Press 2006
Mechanism of action of Clostridium perfringens enterotoxin. (共著)
Plenum Press, New York 1996

Lectures and oral presentations (25)：

「細菌感染病理に関わる細菌毒素の作用機序」
(2023年度第33回学会賞受賞者特別講演会 2024)
パラ百日咳菌による咳発作惹起メカニズムに関与する新たな毒素、DAT
(第69回トキシンシンポジウム 2023)
百日咳菌のBvgASシステムを不活性化する化合物Xとその機能解析
(第17回細菌学若手コロッセウム 2023)
Genome-wide Screening Reveals RpoN Contributing to the Survival Fitness of Bordetella bronchiseptica within Rat Tracheas
(第17回細菌学若手コロッセウム 2023)
細菌感染病理に関わる細菌毒素の作用機序についての研究
(第96回日本細菌学会総会 2023)

ｍore...

Education (4)：

- 1987 Osaka Prefecture University
- 1987 Osaka Prefecture University Graduate School, Division of Agriculture Veterinary Science
- 1982 Osaka Prefecture University
- 1982 Osaka Prefecture University Faculty of Agriculture Veterinary Science

Professional career (1)：

Doctor of Agriculture (Osaka Prefecture University)

Work history (10)：

2021/04 - 現在 Osaka University Center for Infectious Disease Education and Research
2001/04 - 現在 Osaka University Research Institute for Microbial Diseases Professor
1998 - 2001 Osaka University Research Institute for Microbial Diseases
1998 - 2001 Institute for Microbial Diseases. Osaka Univ., Assistant Professor
1992 - 1998 Osaka University Research Institute for Microbial Diseases

Show all

Awards (3)：

2023/03 - 第96回日本細菌学会総会第96回日本細菌学会総会優秀発表賞
2023/03 - 日本細菌学会日本細菌学会浅川賞
1996 - 日本細菌学会黒屋奨学賞

Association Membership(s) (3)：

日本分子生物学会 , 日本獣医学会 , 日本細菌学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page