Research theme for competitive and other funds (9):
2022 - 2024 がん細胞の細胞膜張力を標的とした化合物の探索と治療法への応用
2019 - 2022 Mechanism of Cell Membrane Tension Homeostasis by Membrane Tension Sensor Proteins
2016 - 2018 細胞膜の張力を可視化するプローブの開発
2017 - 【AMED】癌細胞の浸潤・転移を司る細胞膜の張力を介したシグナル伝達機構の解明
2011 - 2016 Regulation of cell dynamism by phosphoinositides
2013 - 2016 細胞膜の張力を介したアクチン重合制御機構の解明
2012 - 2015 Molecular mechanism of endocytosis by a novel membrane-bending domain
2011 - アクチンカップ形成におけるEFC/F-BARタンパク質であるFBP17の役割
2008 - 自己炎症性疾患の原因タンパク質であるPSTPIPsの細胞運動における役割
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Papers (25):
Toshiki Itoh, Kazuya Tsujita. Exploring membrane mechanics: The role of membrane-cortex attachment in cell dynamics. Current Opinion in Cell Biology. 2023. 81. 102173-102173
Toshiki Itoh, Kazuya Tsujita. Exploring membrane mechanics: The role of membrane-cortex attachment in cell dynamics. Current opinion in cell biology. 2023. 81. 102173-102173
Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, et al. Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Nature communications. 2022. 13. 1. 2594-2594
Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, et al. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics. Nature communications. 2022. 13. 1. 2347-2347
Kazuya Tsujita, Reiko Satow, Shinobu Asada, Yoshikazu Nakamura, Luis Arnes, Keisuke Sako, Yasuyuki Fujita, Kiyoko Fukami, Toshiki Itoh. Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly. Nature communications. 2021. 12. 1. 5930-5930
辻田和也, 伊藤俊樹. Cancer cell migration: Regulation of cancer cell migration by plasma membrane tension and membrane curvature-inducing proteins. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
伊藤 俊樹, 及川 司, 辻田 和也, 竹縄 忠臣. PI3Kおよび関連シグナル伝達分子の機能 癌細胞におけるD3-ホスホイノシチドの定量化と視覚化のためのホスホイノシチド結合ドメインの利用(Use of phosphoinositide-binding domains for the quantification and visualization of D3-phosphoinositides in cancer cells). 日本発生生物学会・日本細胞生物学会合同大会要旨集. 2007. 40回・59回. 15-15