Rchr
J-GLOBAL ID：200901019822298363   Update date: Oct. 18, 2024

Hasegawa Masato

Hasegawa Masato
Affiliation and department：
Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function

About Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function


Job title： Head of Department
Homepage URL  (1)： http://www.igakuken.or.jp/
Research field  (3)： Neurology ,  Neuroscience - general ,  Molecular biology
Research keywords  (19)： Tauopathies ,  Pick disease ,  progressive supranuclear pulsy ,  corticobasal degeneration ,  Alzheimer disease ,  multiple system atrophy ,  Dementia with Lewy bodies ,  Parkinson disease ,  ALS ,  Prions ,  amyloid fibril formation ,  TDP-43 ,  FTLD ,  α-Synuclein ,  neurodegenerative diseases ,  ubiquitin ,  inclusions ,  phosphorylation ,  Tau
Research theme for competitive and other funds  (18)：
  • 2015 - 2018 Propagation of prion-like proteins and cellular responses
  • 2015 - 2017 The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations
  • 2012 - 2016 Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementia
  • 2011 - 2014 Molecular mechanisms of pathological protein propagation and its regulation
  • 2008 - 2009 神経変性疾患における異常蛋白質蓄積機構の解明
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Papers (382)：
  • Masanori Kurihara, Akira Arakawa, Aya Midori Tokumaru, Tomoyasu Matsubara, Hiroto Eguchi, Yasushi Shimo, Masato Hasegawa, Kazutomi Kanemaru, Katsuhiko Takeda, Atsushi Iwata, et al. Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation. eNeurologicalSci. 2024. 37. 100526-100526
  • Akira Arakawa, Shigeo Murayama, Satoru Morimoto, Tomoyasu Matsubara, Renpei Sengoku, Masashi Kameyama, Aya M Tokumaru, Airi Tarutani, Masato Hasegawa, Atsushi Iwata, et al. A case of argyrophilic grain disease with an initial clinical diagnosis of Parkinson's disease. Journal of neurology. 2024
  • Anthony Aggidis, George Devitt, Yongrui Zhang, Shreyasi Chatterjee, David Townsend, Nigel J Fullwood, Eva Ruiz Ortega, Airi Tarutani, Masato Hasegawa, Amber Cooper, et al. A novel peptide-based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024
  • Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegawa. Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies. Scientific reports. 2024. 14. 1. 22892-22892
  • Diana Arseni, Takashi Nonaka, Max H Jacobsen, Alexey G Murzin, Laura Cracco, Sew Y Peak-Chew, Holly J Garringer, Ito Kawakami, Hisaomi Suzuki, Misumoto Onaya, et al. Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C. Nature. 2024. 634. 8034. 662-668
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MISC (194)：
  • 木村妙子, 鈴掛雅美, 橋本雅史, 久永眞市, 富田泰輔, 長谷川成人. 本シンポジウムの趣旨及び新規TBIモデルCHIMERAについて. Dementia Japan. 2023. 37. 4
  • 木村妙子, 鈴掛雅美, 橋本雅史, 久永眞市, 富田泰輔, 長谷川成人. 外傷性脳損傷の新規モデルを用いたタウオパチー病理研究. Dementia Japan. 2023. 37. 4
  • 樽谷愛理, 長谷川成人. Structural and biochemical classification of tauopathies. 医学のあゆみ. 2023. 287. 13
  • 勇亜衣子, 長谷川成人. プリオン機序. Clin Neurosci. 2023. 41. 3. 361-364
  • 樽谷愛理, 長谷川成人. Biochemical and structural classification of human tauopathies. Bio Clinica. 2023. 38. 3. 6-10
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Books (6)：
  • Structure of NFT: Biochemical Approach.
    Adv Exp Med Biol. 2019; 1184:23-34. 2019
  • TDP-43 prions.
    Cold Spring Harbor Laboratory Press 2017
  • α-Synuclein: Experimental pathology.
    Cold Spring Harbor Laboratory Press 2016
  • Molecular Biology of Dementia with Lewy Bodies,
    Springer, Edited by Kenji Kosaka. 2016
  • Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.
    Pharmacol Ther 172: 22-33, 2017
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Lectures and oral presentations  (50)：
  • プロテイノパチーとしての神経変性疾患
    (湯島Neurology Seminar 2023 2023)
  • 対談 続・宇宙兄弟がつなぐ難病・ALSへの挑戦.
    (第28回 日本難病看護学会 学術集会 市民公開講座 2023)
  • 神経変性関連タンパク質の構造と性質
    (第12回 東北パーキンソン病研究会 2023)
  • Prion-like propagation of pathological proteins in neurodegenerative disorders
    (2023)
  • 神経変性疾患における病原タンパク質の凝集と伝播
    (第34回日本緑内障学会 特別企画 2023)
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Professional career (1)：
  • 博士(医学) (東京大学)
Work history (7)：
  • 2020/04 - 現在 Tokyo Metropolitan Institute of Medical Science Department of Brain and Neurosciences Head of Department, Project leader of Dementia Research Project
  • 2016/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Department, Project leader of Dementia Research Project
  • 2011/04 - 2016/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Neurobiology laboratory
  • 2001/04 - 2011/03 Tokyo Institute of Psychiatry Neurobiology Group Head
  • 1999/02 - 2000/03 The University of Tokyo Faculty of Pharmaceutical Sciences Associate Professor
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Awards (7)：
  • 2022/09 - Citation Laureate 2022 For the identification of TDP-43, a pathological signature of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and for other contributions to the study of neurodegenerative diseases
  • 2022/04 - 公益信託時実利彦記念脳研究助成基金 時実利彦記念賞 神経変性疾患における異常タンパク質の病変形成機構
  • 2015/02 - Tokyo Metropolitan Government Tokyo medal award
  • 2008/10 - Japanese Society for Dementia Research Japanese Society for Dementia Research Prize
  • 2007/11 - Tokyo Metropolitan Government Tokyo medal award 2007
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Association Membership(s) (4)：
THE JAPANESE SOCIETY OF NEUROPATHOLOGY ,  Japan Society for Dementia Research ,  日本神経科学学会 ,  日本神経学会
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