Rchr
J-GLOBAL ID:200901019822298363   Update date: Jun. 29, 2022

Hasegawa Masato

Hasegawa Masato
Affiliation and department:
Job title: Head of Department
Homepage URL  (1): http://www.igakuken.or.jp/
Research field  (3): Neurology ,  Neuroscience - general ,  Molecular biology
Research keywords  (19): Tauopathies ,  Pick disease ,  progressive supranuclear pulsy ,  corticobasal degeneration ,  Alzheimer disease ,  multiple system atrophy ,  Dementia with Lewy bodies ,  Parkinson disease ,  ALS ,  Prions ,  amyloid fibril formation ,  TDP-43 ,  FTLD ,  α-Synuclein ,  neurodegenerative diseases ,  ubiquitin ,  inclusions ,  phosphorylation ,  Tau
Research theme for competitive and other funds  (14):
  • 2008 - 2009 神経変性疾患における異常蛋白質蓄積機構の解明
  • 2007 - 2009 筋萎縮性側索硬化症と前頭側頭型認知症の脳に蓄積する核内蛋白質の解析と病態の解明
  • 2006 - 2008 神経変性疾患における蛋白質の構造変化と細胞変性機構に関する研究
  • 2006 - 2007 タウ、αシヌクレイン、アミロイドβ蛋白を介した神経変性の解明と治療に関する研究
  • 2005 - 2005 タウ、aシヌクレインを介した神経変性の解明と治療に関する研究
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Papers (310):
  • Takahiro Akasaka, Hiroyuki Watanabe, Sho Kaide, Shimpei Iikuni, Masato Hasegawa, Masahiro Ono. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorganic & medicinal chemistry letters. 2022. 64. 128679-128679
  • Hiroaki Miyahara, Akio Akagi, Yuichi Riku, Jun Sone, Yasushi Otsuka, Motoko Sakai, Satoshi Kuru, Masato Hasegawa, Mari Yoshida, Akiyoshi Kakita, et al. Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies. Brain pathology (Zurich, Switzerland). 2022. e13069
  • Goichi Beck, Kazue Shigenobu, Koto Ukon, Rika Yamashita, Yuki Yonenobu, Eiichi Morii, Masato Hasegawa, Manabu Ikeda, Shigeo Murayama, Hideki Mochizuki. An autopsy case of Alzheimer's disease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like psychiatric symptoms. Neuropathology : official journal of the Japanese Society of Neuropathology. 2022. 42. 2. 147-154
  • Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, et al. Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature. 2022
  • Yuichi Riku, Yasushi Iwasaki, Shinsuke Ishigaki, Akio Akagi, Masato Hasegawa, Kenya Nishioka, Yuanzhe Li, Miho Riku, Takeshi Ikeuchi, Yusuke Fujioka, et al. Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration. Brain : a journal of neurology. 2022
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MISC (75):
Books (6):
  • Structure of NFT: Biochemical Approach.
    Adv Exp Med Biol. 2019; 1184:23-34. 2019
  • TDP-43 prions.
    Cold Spring Harbor Laboratory Press 2017
  • α-Synuclein: Experimental pathology.
    Cold Spring Harbor Laboratory Press 2016
  • Molecular Biology of Dementia with Lewy Bodies,
    Springer, Edited by Kenji Kosaka. 2016
  • Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.
    Pharmacol Ther 172: 22-33, 2017
more...
Lectures and oral presentations  (8):
  • α-SYNUCLEIN - CAN IT FORM PRIONS ?.
    (World Congress of Neurology 2019 (WCN2019) 2019)
  • Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies -Prion-Like Seeded Aggregation and Phosphorylation-.
    (3rd ITCN & 2019 AMTNS. 2019)
  • Prion-like propagation of pathological tau in neurodegenerative diseases
    (Japan-UK Neuroscience Symposium 2019)
  • Prion-like propagation of pathological tau in neurodegenerative diseases.
    (ICN2018 2018)
  • α-Synuclein Propagation in Parkinson’s Disease and Multiple System Atrophy
    (MDS/Education/Conferences & Courses 2018)
more...
Professional career (1):
  • 博士(医学) (東京大学)
Work history (7):
  • 2020/04 - 現在 Tokyo Metropolitan Institute of Medical Science Department of Brain and Neurosciences Head of Department, Project leader of Dementia Research Project
  • 2016/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Department, Project leader of Dementia Research Project
  • 2011/04 - 2016/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Neurobiology laboratory
  • 2001/04 - 2011/03 Tokyo Institute of Psychiatry Neurobiology Group Head
  • 1999/02 - 2000/03 The University of Tokyo Faculty of Pharmaceutical Sciences Associate Professor
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Awards (6):
  • 2022/04 - 公益信託時実利彦記念脳研究助成基金 時実利彦記念賞 神経変性疾患における異常タンパク質の病変形成機構
  • 2015/02 - Tokyo Metropolitan Government Tokyo medal award
  • 2008/10 - Japanese Society for Dementia Research Japanese Society for Dementia Research Prize
  • 2007/11 - Tokyo Metropolitan Government Tokyo medal award 2007
  • 1999 - FEBS Letters The Semenza Prize
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Association Membership(s) (4):
THE JAPANESE SOCIETY OF NEUROPATHOLOGY ,  Japan Society for Dementia Research ,  日本神経科学学会 ,  日本神経学会
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