Rchr
J-GLOBAL ID：200901019822298363   Update date: Apr. 17, 2024

Hasegawa Masato

Hasegawa Masato
Affiliation and department：
Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function

About Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function


Job title： Head of Department
Homepage URL  (1)： http://www.igakuken.or.jp/
Research field  (3)： Neurology ,  Neuroscience - general ,  Molecular biology
Research keywords  (19)： Tauopathies ,  Pick disease ,  progressive supranuclear pulsy ,  corticobasal degeneration ,  Alzheimer disease ,  multiple system atrophy ,  Dementia with Lewy bodies ,  Parkinson disease ,  ALS ,  Prions ,  amyloid fibril formation ,  TDP-43 ,  FTLD ,  α-Synuclein ,  neurodegenerative diseases ,  ubiquitin ,  inclusions ,  phosphorylation ,  Tau
Research theme for competitive and other funds  (18)：
  • 2015 - 2018 Propagation of prion-like proteins and cellular responses
  • 2015 - 2017 The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations
  • 2012 - 2016 Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementia
  • 2011 - 2014 Molecular mechanisms of pathological protein propagation and its regulation
  • 2008 - 2009 神経変性疾患における異常蛋白質蓄積機構の解明
Show all
Papers (366)：
  • Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, et al. Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 51. e2306767120
  • Airi Tarutani, Masato Hasegawa. Ultrastructures of α-synuclein filaments in synucleinopathy brains and experimental models. Journal of movement disorders. 2023
  • Ikuko Aiba, Yuichi Hayashi, Takayoshi Shimohata, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori, Masato Hasegawa, Takeshi Ikeuchi, Aya M Tokumaru, et al. Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome. Brain Communications. 2023. 5. 6
  • 河上 緒, 野中 隆, 原 範和, 宮下 哲典, 亀谷 富由樹, 鴻江 真維, 佐藤 祐太, 田平 万莉奈, 長谷川 舞衣, 月江 珠緒, et al. 新規L344F変異を有するPick diseaseの多面的病態解析. Dementia Japan. 2023. 37. 4. 662-662
  • 永倉 暁人, 河上 緒, 木村 朴, 池田 研二, 櫻井 圭太, 新里 和弘, 大島 健一, 長谷川 成人, 加藤 忠史. 易怒性,幻覚妄想を伴い,PART主体の病理像を呈した超高齢者の神経病理学的検討. 老年精神医学雑誌. 2023. 34. 増刊II. 216-216
ｍore...
MISC (192)：
  • 樽谷愛理, 長谷川成人. Structural and biochemical classification of tauopathies. 医学のあゆみ. 2023. 287. 13
  • 勇亜衣子, 長谷川成人. プリオン機序. Clin Neurosci. 2023. 41. 3. 361-364
  • 樽谷愛理, 長谷川成人. Biochemical and structural classification of human tauopathies. Bio Clinica. 2023. 38. 3. 6-10
  • 長谷川成人. 総論 プロテイノパチー研究の新時代. BIO Clinica. 2023. 38. 3. 4-5
  • 樽谷愛理, 長谷川成人. クライオ電子顕微鏡によるタウタンパク質の構造解析診断での有用性. Annual Review 神経 2023. 2023. 2023
ｍore...
Books (6)：
  • Structure of NFT: Biochemical Approach.
    Adv Exp Med Biol. 2019; 1184:23-34. 2019
  • TDP-43 prions.
    Cold Spring Harbor Laboratory Press 2017
  • α-Synuclein: Experimental pathology.
    Cold Spring Harbor Laboratory Press 2016
  • Molecular Biology of Dementia with Lewy Bodies,
    Springer, Edited by Kenji Kosaka. 2016
  • Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.
    Pharmacol Ther 172: 22-33, 2017
ｍore...
Lectures and oral presentations  (50)：
  • プロテイノパチーとしての神経変性疾患
    (湯島Neurology Seminar 2023 2023)
  • 対談 続・宇宙兄弟がつなぐ難病・ALSへの挑戦.
    (第28回 日本難病看護学会 学術集会 市民公開講座 2023)
  • 神経変性関連タンパク質の構造と性質
    (第12回 東北パーキンソン病研究会 2023)
  • Prion-like propagation of pathological proteins in neurodegenerative disorders
    (2023)
  • 神経変性疾患における病原タンパク質の凝集と伝播
    (第34回日本緑内障学会 特別企画 2023)
ｍore...
Professional career (1)：
  • 博士(医学) (東京大学)
Work history (7)：
  • 2020/04 - 現在 Tokyo Metropolitan Institute of Medical Science Department of Brain and Neurosciences Head of Department, Project leader of Dementia Research Project
  • 2016/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Department, Project leader of Dementia Research Project
  • 2011/04 - 2016/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Neurobiology laboratory
  • 2001/04 - 2011/03 Tokyo Institute of Psychiatry Neurobiology Group Head
  • 1999/02 - 2000/03 The University of Tokyo Faculty of Pharmaceutical Sciences Associate Professor
Show all
Awards (7)：
  • 2022/09 - Citation Laureate 2022 For the identification of TDP-43, a pathological signature of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and for other contributions to the study of neurodegenerative diseases
  • 2022/04 - 公益信託時実利彦記念脳研究助成基金 時実利彦記念賞 神経変性疾患における異常タンパク質の病変形成機構
  • 2015/02 - Tokyo Metropolitan Government Tokyo medal award
  • 2008/10 - Japanese Society for Dementia Research Japanese Society for Dementia Research Prize
  • 2007/11 - Tokyo Metropolitan Government Tokyo medal award 2007
Show all
Association Membership(s) (4)：
THE JAPANESE SOCIETY OF NEUROPATHOLOGY ,  Japan Society for Dementia Research ,  日本神経科学学会 ,  日本神経学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM