Rchr
J-GLOBAL ID:200901019822298363   Update date: Sep. 01, 2020

hasegawa masato

hasegawa masato
Affiliation and department:
Job title: Head of Department
Homepage URL  (1): http://www.igakuken.or.jp/
Research field  (3): Molecular biology ,  Neurology ,  Neuroscience - general
Research keywords  (19): Tauopathies ,  Pick disease ,  progressive supranuclear pulsy ,  corticobasal degeneration ,  Alzheimer disease ,  multiple system atrophy ,  Dementia with Lewy bodies ,  Parkinson disease ,  amyloid fibril formation ,  FTLD ,  ALS ,  phosphorylation ,  inclusions ,  ubiquitin ,  neurodegenerative diseases ,  α-Synuclein ,  TDP-43 ,  Tau ,  Prions
Research theme for competitive and other funds  (14):
  • 2008 - 2009 神経変性疾患における異常蛋白質蓄積機構の解明
  • 2007 - 2009 筋萎縮性側索硬化症と前頭側頭型認知症の脳に蓄積する核内蛋白質の解析と病態の解明
  • 2006 - 2008 神経変性疾患における蛋白質の構造変化と細胞変性機構に関する研究
  • 2006 - 2007 タウ、αシヌクレイン、アミロイドβ蛋白を介した神経変性の解明と治療に関する研究
  • 2005 - 2005 タウ、aシヌクレインを介した神経変性の解明と治療に関する研究
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Papers (224):
  • Akira Arakawa, Yuko Saito, Tomonari Seki, Akihiko Mitsutake, Tatsuya Sato, Junko Katsumata, Risa Maekawa, Takuto Hideyama, Koichi Tamura, Masato Hasegawa, et al. Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy. Neuropathology : official journal of the Japanese Society of Neuropathology. 2020. 40. 3. 287-294
  • Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, et al. Structures of α-synuclein filaments from multiple system atrophy. Nature. 2020
  • Takashi Nonaka, Masato Hasegawa. Prion-like properties of assembled TDP-43. Current Opinion in Neurobiology. 2020. 61. 23-28
  • Wenjuan Zhang, Airi Tarutani, Kathy L Newell, Alexey G Murzin, Tomoyasu Matsubara, Benjamin Falcon, Ruben Vidal, Holly J Garringer, Yang Shi, Takeshi Ikeuchi, et al. Novel tau filament fold in corticobasal degeneration. Nature. 2020
  • Hideki Hayakawa, Rie Nakatani, Kensuke Ikenaka, Cesar Aguirre, Chi-Jing Choong, Hiroshi Tsuda, Seiichi Nagano, Masato Koike, Takeshi Ikeuchi, Masato Hasegawa, et al. Structurally Distinct α-Synuclein Fibrils Induce Robust Parkinsonian Pathology. Movement Disorders. 2020. 35. 2. 256-267
more...
MISC (43):
  • Hideki Hayakawa, Rie Nakatani, Kensuke Ikenaka, Cesar Aguirre, Chi-Jing Choong, Hiroshi Tsuda, Seiichi Nagano, Masato Koike, Takeshi Ikeuchi, Masato Hasegawa, et al. Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology. Movement disorders : official journal of the Movement Disorder Society. 2020. 35. 2. 256-267
  • AKIYAMA HARUHIKO, HAYASHI ZEN, KAWAKAMI ITO, AOKI NAOYA, AZUMA SHINJI, HOSOKAWA MASATO, IKEDA KENJI, ONAYA MITSUKI, OSHIMA KEN'ICHI, NIIZATO KAZUHIRO, et al. 異常タンパク伝播仮説に基づく神経疾患の画期的治療法の開発 側坐核におけるタウ蓄積と神経回路. 異常タンパク伝播仮説に基づく神経疾患の画期的治療法の開発 平成26年度 総括・分担研究報告書. 2015. 28-31
  • HASEGAWA MASATO, SUZUKAKE MASAMI, NONAKA TAKASHI, SHIMOZAWA AKI, HOSOKAWA MASATO, AKIYAMA HARUHIKO. 異常タンパク伝播仮説に基づく神経疾患の画期的治療法の開発 異常αシヌクレインの神経回路伝播. 異常タンパク伝播仮説に基づく神経疾患の画期的治療法の開発 平成26年度 総括・分担研究報告書. 2015. 15-20
  • HOSOKAWA MASATO, ARAI TETSUAKI, MASUDA(SUZUKAKE) MASAMI, KONDO HIROMI, MATSUWAKI TAKASHI, NISHIHARA MASUGI, HASEGAWA MASATO, AKIYAMA HARUHIKO. 異常タンパク伝播仮説に基づく神経疾患の画期的治療法の開発 プログラニュリンの減少はタウのリン酸化を亢進させる. 異常タンパク伝播仮説に基づく神経疾患の画期的治療法の開発 平成26年度 総括・分担研究報告書. 2015. 32-35
  • Masato Hasegawa. Are neurodegenerative diseases "protein cancers"?. Brain and Nerve. 2012. 64. 6. 675-679
more...
Books (6):
  • Structure of NFT: Biochemical Approach.
    Adv Exp Med Biol. 2019; 1184:23-34. 2019
  • TDP-43 prions.
    Cold Spring Harbor Laboratory Press 2017
  • α-Synuclein: Experimental pathology.
    Cold Spring Harbor Laboratory Press 2016
  • Molecular Biology of Dementia with Lewy Bodies,
    Springer, Edited by Kenji Kosaka. 2016
  • Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.
    Pharmacol Ther 172: 22-33, 2017
more...
Lectures and oral presentations  (8):
  • α-SYNUCLEIN - CAN IT FORM PRIONS ?.
    (World Congress of Neurology 2019 (WCN2019) 2019)
  • Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies -Prion-Like Seeded Aggregation and Phosphorylation-.
    (3rd ITCN & 2019 AMTNS. 2019)
  • Prion-like propagation of pathological tau in neurodegenerative diseases
    (Japan-UK Neuroscience Symposium 2019)
  • Prion-like propagation of pathological tau in neurodegenerative diseases.
    (ICN2018 2018)
  • α-Synuclein Propagation in Parkinson’s Disease and Multiple System Atrophy
    (MDS/Education/Conferences & Courses 2018)
more...
Professional career (1):
  • 博士(医学) (東京大学)
Work history (7):
  • 2020/04 - 現在 Tokyo Metropolitan Institute of Medical Science Department of Brain and Neurosciences Head of Department, Project leader of Dementia Research Project
  • 2016/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Department, Project leader of Dementia Research Project
  • 2011/04 - 2016/03 Tokyo Metropolitan Institute of Medical Science Department of Dementia and Higher Brain Function Head of Neurobiology laboratory
  • 2001/04 - 2011/03 Tokyo Institute of Psychiatry Neurobiology Group Head
  • 1999/02 - 2000/03 The University of Tokyo Faculty of Pharmaceutical Sciences Associate Professor
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Awards (5):
  • 2015/02 - Tokyo Metropolitan Government Tokyo medal award
  • 2008/10 - Japanese Society for Dementia Research Japanese Society for Dementia Research Prize
  • 2007/11 - Tokyo Metropolitan Government Tokyo medal award 2007
  • 1999 - FEBS Letters The Semenza Prize
  • 1995 - Human Frontier Science Program Human Frontier Science Program, Long-term Fellowship
Association Membership(s) (4):
THE JAPANESE SOCIETY OF NEUROPATHOLOGY ,  The Japanese Biochemical Society ,  Japan Society for Dementia Research ,  Journal of Biochemical Chemistry, Editorial Board Member
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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