Research field (2)：
Neuroscience - general
, Neurology
Research keywords (2)：
amyotrophic lateral sclerosis
, neurodegenerative diseases
Research theme for competitive and other funds (8)：
2022 - 2024 神経細胞内鉄代謝障害に基づく筋萎縮性側索硬化症の病態解明
2021 - 2024 Elucidation of the pathogenesis and development of the treatment strategy of ALS/FTLD focusing on the local translation in neuronal axons
2016 - 2020 Investigation of ALS/FTLD pathogenesis based on translational deterioration due to ribosome dysfunction in axons
2015 - 2018 Investigation of key molecules involved in bidirectional interactions between diabetes and dementia
2013 - 2016 Pathogenesis of TDP-43 proteinopathy based on the transport defect of target mRNA
2010 - 2012 Elucidation of the neuronal toxicity mechanism by TDP-43 based on dysfunction of the nucleocytoplasmic shuttling
2004 - 2005 家族性筋萎縮性側索硬化症における変異SOD1特異的銅親和性の解析
2004 - 2004 家族性筋萎縮性側索硬化症における変異SOD1特異的銅親和性の解析
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Papers (63)：
Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, et al. Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD. Acta Neuropathologica Communications. 2024. 12. 1
Keita Kakuda, Kensuke Ikenaka, Akiko Kuma, Junko Doi, César Aguirre, Nan Wang, Takahiro Ajiki, Chi-Jing Choong, Yasuyoshi Kimura, Shaymaa Mohamed Mohamed Badawy, et al. Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles. Proceedings of the National Academy of Sciences. 2023. 121. 1
Mikito Shimizu, Naoyuki Shiraishi, Satoru Tada, Tsutomu Sasaki, Goichi Beck, Seiichi Nagano, Makoto Kinoshita, Hisae Sumi, Tomoyuki Sugimoto, Yoko Ishida, et al. RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS. Science Advances. 2023. 9. 47
Toshihide Takeuchi, Kazuhiro Maeta, Xin Ding, Yukako Oe, Akiko Takeda, Mana Inoue, Seiichi Nagano, Tsuyoshi Fujihara, Seiji Matsuda, Shinsuke Ishigaki, et al. Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice. Molecular therapy. Nucleic acids. 2023. 31. 353-366
Chi Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, et al. Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism. ACTA NEUROPATHOLOGICA. 2023. 145. 5. 573-595
- 1992 Osaka University Faculty of Medicine Medical School
Association Membership(s) (8)：
JAPAN SOCIETY FOR DEMENTIA RESEARCH
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
, Society for Neuroscience
, THE JAPAN NEUROSCIENCE SOCIETY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, JAPANESE SOCIETY OF NEUROLOGY
, 日本人類遺伝学会
