Rchr

J-GLOBAL ID：200901020148842646 Update date: Sep. 19, 2024

Miyazawa Masaaki

ミヤザワマサアキ | Miyazawa Masaaki

Affiliation and department：
Job title： Senior Director
Other affiliations (1)：

Kindai University Visiting Professor

Homepage URL (1)： https://www.researchgate.net/profile/Masaaki_Miyazawa

Research field (4)： Immunology , Virology , Experimental pathology , Medical biochemistry

Research keywords (11)： epitopes , CD4-positive T-lymphocyte , T-lymphocyte , vaccine , Vaccine strategies , 自己免疫病 , 免疫応答遺伝子 , 感染抵抗性 , Autoimmune disease , Immune regulatory genes , Resistance to infection

Research theme for competitive and other funds (51)：

2024 - 2027 胆管上皮免疫応答を標的とした母親由来細胞キメリズムから解き明かす胆道閉鎖症の病因
2022 - 2025 Mechanisms of B-lymphomagenesis in the absence of APOBEC3 cytidine deaminase
2020 - 2023 Investigation of the mechanism of development and preventive method for endometriosis-associated ovarian cancer
2018 - 2023 Development of new treatment for ovarian cancer based on intratumor heterogeneity
2019 - 2022 Elucidation of the mechanisms for leukemogenesis in Friend-virus infected mice

2019 - 2022 レトロウイルス中和抗体産生制御遺伝子の実体と作用機序の解明

2018 - 2021 Comprehensive study on precise diagnosis and new chemotherapy for micrometastatic lymph nodes

2016 - 2019 The requirement of B cell-intrinsic TLR7 for the protection of retrovirus-induced leuchemia

2016 - 2019 Clinical utilization and investigation of ovarian cancer genome diversity associated with metastasis, resistance to treatment and immune escape

2016 - 2019 Molecular mechanism of APOBEC3-mediated inhibition on Gag-Pol autoprocessing

2016 - 2019 マウスAPOBEC3のプロテアーゼ抑制機構解明による新規抗レトロウイルス薬開発

2014 - 2017 Development of early diagnosis and treatment for lymph node metastasis

2015 - 2017 細胞内複製制限因子APOBEC3の進化要因としての異種由来レトロウイルス

2013 - 2016 Retroviral immune evasion

2013 - 2016 Autophagy regulation by HIV-1 Vpr

2012 - 2014 Mechanisms of regulation of host immune responses by retrovirus-restricting enzyme APOBEC3

2010 - 2012 The role of mouse APOBEC3 in the regulation of endogenous retrovirus

2009 - 2011 Regulation of APOBEC3 gene expression and its transcript splicing

2008 - 宿主の自然抵抗性を応用した抗HIV/エイズ戦略の開発

2005 - 2006 Mechanisms of the control of chromosome 22 gene expression associated with HIV-1-exposed but uninfected status

2003 - 2004 Molecular mechanisms of vascular injury in an autoantibody-induced model of granulomatous arteritis

2003 - 2004 A new human endogenous retrovirus for the pathogenesis of systemic lupus erythematosus

2003 - 2004 Analyses of host genes that confer immune resistance against human immunodeficiency virus type-1 infection in HIV-1-exposed but uninfected individuals in the overseas cohorts

2003 - 2004 細胞傷害性Tリンパ球はウイルス感染防御に必要か

2001 - 2002 Structural analysis of protective and non-protective T-cell epitopes encoded with in the retroviral gag gene product

1999 - 2001 Elucidation of Pathoptysiological Roles of Immune Chemokines

2001 - HIV曝露非感染状態を決定する宿主遺伝子の同定

2001 - Identification of novel human genes that determines HIV-exposed, uninfected status

1999 - 2000 MECHANISMS OF PROTECTION AGAINST RETROVIRAL INFECTIONS INDUCED WITH A SINGLE-EPITOPE CD4^+ T-CELL VACCINE

1997 - 1999 Engineering of a novel oral herpesvirus vaccine using a gene therapy

1997 - 1998 CD4陽性T細胞はどのようにウイルス感染細胞を排除するか

1996 - 1997 C型肝炎ウィルス特異的ヘルパーTクローン樹立と抗原依存性TH1・TH2分化の検討

1995 - 1997 Use of bovine-RBC-substituted SCID mice for the studies of Babesia parasites

1995 - 1996 Mechanisms of tissue injury induced with anti-gp70 autoantibodies

1994 - 1994 多価合成ペプチドワクチンによるレトロウイルス感染防御免疫の誘導

1993 - 1993 レトロウイルスGag抗原上の細胞障害性T細胞エピトープの同定と感染防御への応用

1993 - 1993 モノクローナル抗体による血栓性血小板減少性紫斑病モデルの発症メカニズ

1992 - 1992 自己免疫病モデルマウスからの抗gp70モノクロナル抗体の樹立と病原性の解析

1992 - 1992 gag抗原合成ペプチドによるレトロウイルス感染防御免疫の誘導

1992 - レトロウイルス感染に対する防御免疫反応の宿主遺伝子による制御

1992 - レトロウイルス感染に対する宿主免疫応答の抗原特異性と認識エピトープ構造

1992 - 自己免疫病モデルマウス由来抗gp70モノクローナル抗体による腎炎・血管炎の形成

1992 - Host genetic control of protective immune responses against retroviral infections

1992 - Antigen specificity and epitope structures in host immune responses to retroviruses

1992 - Pathogenicity of antiretroviral gp70 monoclonal antibodies established from autoimmune strains of mice

1991 - 1991 レトロウイルスコア抗原による感染防御免疫の誘導

1985 - 1987 Experimental Pathology of Granuloma Formation

自己免疫病の病因解明

Molecular identification of host genetic factors determining HIV-exposed but uninfected status and its application for AIDS prevention and therapy

Analysis on the pathogenesis of autoimmune diseases

Vaccine development aiming at HIV infection

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Papers (124)：

Yoshiyuki Hakata, Kazuma Yamashita, Sonoko Hashimoto, Takashi Ohtsuki, Masaaki Miyazawa, Mizuki Kitamatsu. Adjusting Heterodimeric Coiled-Coils (K/E Zipper) to Connect Autophagy-Inducing Peptide with Cell-Penetrating Peptide. Pharmaceutics. 2023. 15. 4
Tomomasa Izumiyama, Masaaki Miyazawa. Importance of tenosynovitis in preventing the progression through rheumatoid arthritis continuum. Modern Rheumatology. 2022
Masaaki Miyazawa, Mario Clerici. Editorial: Host Immune Responses to Retroviral Infections. Frontiers in Virology. 2022. 2
Kenta Teruya, Ayumi Oguma, Satoko Takahashi, Miki Watanabe-Matsui, Sachiyo Tsuji-Kawahara, Masaaki Miyazawa, Katsumi Doh-ura. Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor α, T-cell receptor δ, or lytic granule function. International Immunopharmacology. 2022. 107. 108672-108672
Shota Tsukimoto, Yoshiyuki Hakata, Sachiyo Tsuji-Kawahara, Takuji Enya, Tetsuo Tsukamoto, Seiya Mizuno, Satoru Takahashi, Shinichi Nakao, Masaaki Miyazawa. Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells. Viruses. 2022. 14. 4. 832-832

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MISC (51)：

SHIOZAWA Shunichi, TSUMIYAMA Ken, MIYAZAKI Yumi, UTO Kenichi, SAKURAI Keiichi, HORIUCHI Takahiko, MATSUBARA Tsukasa, YAMANE Takashi, MUKAI Yohei, ENYA Takuji, et al. DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus (SLE). 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51
中村高大, 井上健, 藤本翔夢, 北松瑞生, 宮澤正顯, 博多義之. Intracellular delivery of functional peptides using heterodimeric leucine zippers containing unnatural amino acids. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
Shunichi Shiozawa, Ken Tsumiyama, Yumi Miyazaki, Kenichi Uto, Keiichi Sakurai, Toshie Nakashima, Hiroko Matsuyama, Ai Doi, Miho Tarui, Manabu Izumikawa, et al. DOCK8-expressing Tfh cells cause SLE: autoimmunity via repeated TCR stimulation by antigen to levels that surpass system's self-organized criticality. JOURNAL OF IMMUNOLOGY. 2021. 206
井上健, 北松瑞生, 山下和真, 宮澤正顯, 博多義之. Conjugation of a functional peptide with a cell-penetrating peptide via “peptide fastener“ and evaluation of the intracellular activity. 日本化学会春季年会講演予稿集(Web). 2021. 101st
櫻空, 北松瑞生, 金本達也, 宮澤正顯, 博多義之. Synthesis and evaluation of a conjugate of apoptosis-inducing peptide with cell penetrating peptide containing photodegradable linker. 日本化学会春季年会講演予稿集(Web). 2021. 101st

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Patents (7)：

Marker Genes
新規ヒト内在性レトロウイルスHC2のenv遺伝子
Resistance Genes
Method for diagnosis and induction of resistance to virus.
Marker Genes

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Books (9)：

コロナウイルスのころなっちとぼく
チャイルド社 2020 ISBN:9784925258524
解明病理学病気のメカニズムを解く
医歯薬出版 2009 ISBN:9784263731154
述2
明石書店 2008 ISBN:9784750327495
Host genes that influence immune and non-immune resistance mechanisms against retrovrial infections
Recent Research Developements in Virology 2005
Host genes that influence immune and non-immune resistance mechanisms against retrovrial infections
Recent Research Developements in Virology 2005

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Lectures and oral presentations (22)：

HIV感染移行性の分子機構: Rac2とAPOBEC3
(第24回日本エイズ学会学術集会・総会 2010)
性感染症の最近の動向: HIVと性器クラミジアを中心に (教育講演)
(第19回日本口腔感染症学会総会・学術大会 2010)
レトロウイルス遺伝子発現と糸球体病変: 拡大するヒトレトロウイルスの世界 (特別講演)
(第45回日本小児腎臓病学会学術集会 2010)
Genetic factors that confer resistance to HIV-1 acquisition in HIV-1-exposed but seronegative individuals in Italy and Thailand.
(4th Nagasaki Symposium on Tropical and Emerging Infectious Diseases. 2009)
New metabolic markers derived from gamma and deltaretrovirus envelope glycoproteins.
(21st International Workshop on Retroviral Pathogenesis. 2009)

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Works (13)：

温熱によるC-型肝炎ウイルス免疫応答の増強
2001 - 2007
Enhancement of immune responses against HCV by heat treatment(hyperthermia)
2001 - 2007
新型インフルエンザワクチンの作用機序
2006 -
ヘルパーT細胞を活性化するエイズワクチンの開発
2000 - 2005
Development of helper T-cell vaccines against HIV infection
2000 - 2005

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Education (4)：

- 1983 Tohoku University
- 1983 Tohoku University Division of Medical Science
- 1982 Tohoku University Faculty of Medicine School of Medicine
- 1982 Tohoku University Faculty of Medicine

Professional career (2)：

Doctor of Medical Sciences (Ph.D.) (Tohoku University)
M.D. (Tohoku University)

Work history (10)：

2023/04 - 現在 Kindai University Visiting Professor
2023/04 - 現在 Shin Nippon Biomedical lLaboratories, Ltd. Research and Development Center for Nasal Mucosal Vaccine Senior Director
1996/04 - 2023/03 Professor and Chairman of the Department of Immunology, Kindai University Faculty of Medicine
2016/10 - 2022/09 Dean, Kindai University Graduate School of Medical Sciences Dean
1995/08 - 1996/03 Associate Professor, Mie University School of Medicine

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Committee career (4)：

2011/04 - 現在科学技術振興機構専門委員
1990 - 現在日本病理学会学術評議員
2006/04 - 2023/03 日本学術振興会専門委員
2005 - 2012 大学基準協会相互評価委員

Awards (5)：

2007 - 内藤記念科学奨励金
2002 - ノバルティスリウマチ医学賞
2002 - Novartis Rheumatism Research Award
1990 - 難病医学研究財団研究奨励助成金
1989 - 東北大学医学部奨学賞

Association Membership(s) (7)：

日本ワクチン学会 , アメリカ微生物学会(American Society for Microbiology) , 日本生体防御学会 , 日本癌学会 , 日本免疫学会 , 日本病理学会 , American Society for Microbiology

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