Rchr
J-GLOBAL ID：200901020591868780   Update date: May. 16, 2026

Kuzuhara Takashi

クズハラ タカシ | Kuzuhara Takashi
Affiliation and department：
Tokushima Bunri University Faculty of Pharmaceutical Sciences, Department of Pharmaceutics

About Tokushima Bunri University Faculty of Pharmaceutical Sciences, Department of Pharmaceutics


Job title： Professor
Homepage URL  (2)： https://www.bunri-u.ac.jp/faculty/pharmacy/ ,  http://p.bunri-u.ac.jp/lab08/index.html
Research field  (9)： Virology ,  Pathobiochemistry ,  Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Cell biology ,  Molecular biology ,  Functional biochemistry ,  Structural biochemistry ,  Genetics
Research keywords  (21)： acetylation ,  Kampo ,  PB2 ,  PA ,  加水分解酵素 ,  RNAポリメラーゼ ,  influenza ,  三次構造解析 ,  構造ドメイン ,  構造解析 ,  ドメイン ,  ヒストン ,  クロマチン ,  endonuclease ,  サリドマイド ,  進化 ,  タミフル ,  阿波番茶 ,  カテキン ,  インフルエンザ ,  influenza virus
Research theme for competitive and other funds  (17)：
  • 2021 - 2024 Epigenetic study of influenza A virus RNA polymerase
  • 2018 - 2022 Differentiation of human iPS cells by CCN
  • 2014 - 2017 Acetylation of the viral histone-like protein, nucleoprotein, in influenza virus affects viral transcriptional activity
  • 2013 - 2015 Screening of inhibitors against influenza A virus PA endonuclease
  • 2010 - 2012 Screening of inhibitors of influenza A virus PA endonuclease
Show all
Papers (74)：
  • Masaki Shoji, Rina Hashimoto, Canan G Nebigil, Kazuto Takegawa, Itsuki Tomita, Kensuke Nakaoka, Momiji Ishikawa, Yasufumi Matsumura, Miki Nagao, Tomoyuki Esumi, et al. Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function. Microbiology spectrum. 2026. e0309325
  • Dai Hatakeyama, Masaki Shoji, Yusuke Miki, Shoji Ueki, Kentaro Yamaguchi, Katsuyuki Nakashima, Yoshiyuki Tanaka, Mariko Yokogawa, Masanori Osawa, Yusuke Kasai, et al. Glycan-binding properties of SARS-CoV-2 spike proteins: interactions with aminoglycoside antibiotics. Scientific reports. 2026. 16. 1
  • Dai Hatakeyama, Masaki Shoji, Takashi Kuzuhara. Pharmacophores of Influenza Virus PA Endonuclease Inhibitors. Advances in experimental medicine and biology. 2026. 1491. 413-445
  • Masaki Shoji, Kensuke Nakaoka, Momiji Ishikawa, Yusuke Kasai, Tomoyuki Esumi, Etsuhisa Takahashi, Hiroshi Kido, Hiroshi Imawaga, Takashi Kuzuhara. Triethylamine inhibits influenza A virus infection and growth via mechanisms independent of viral neuraminidase and RNA-dependent RNA polymerase. PloS one. 2025. 20. 8. e0329964
  • Dai Hatakeyama, Hina Tanii, Erina Nishikawa, Mizuki Takahira, Tsugumi Honjo, Nao Ebisuda, Naoya Abe, Yasuo Shinohara, Shunsuke Mitomo, Ayumi Tsutsui, et al. Anacardic Acid Derivatives Isolated from Fungal Species Tyromyces fissilis as New Histone Acetyltransferase Inhibitors. Biological & pharmaceutical bulletin. 2024. 47. 12. 2076-2082
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MISC (128)：
  • 庄司正樹, 橋本里菜, G. Nebigil Canan, LAURENT Desaubry, 高山和雄, 高山和雄, 葛原隆. Antiviral Activity of the Prohibitin- Binding Melanogenin Derivative Mel56 Against Influenza Virus and SARS-CoV-2. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2025. 72nd
  • 吉田晴菜, 畠山大, 三木悠輔, 庄司正樹, 橋本里菜, 高山和雄, 葛原隆. Screening analyses of sugars and sugar chains interacting with S proteins of SARS-CoV-2. 日本薬学会年会要旨集(Web). 2025. 145th
  • 山西麗, 畠山大, 植木正二, 山口健太郎, 葛原隆. Aminoglycoside antibiotics that interacts with the S protein of SARS-CoV-2. 日本薬学会年会要旨集(Web). 2025. 145th
  • 冨田樹, 庄司正樹, 佐藤雛子, 橋本里奈, DESAUBRY Laurent, 高山和雄, 葛原隆. Anti-influenza and anti-SARS-CoV-2 activities of prohibitin ligand X. 日本薬学会年会要旨集(Web). 2025. 145th
  • 永渕楓華, 庄司正樹, 長瀬早咲, 由利優心, 原貴史, 吉開会美, 福中彩子, 松永安由, 平川由紀, 門間敬子, et al. Effect of ZIP13 point mutation in patients with EDSSPD3 on osteoblast differentiation: Study using patient iPS cells and gene-repaired iPS cells. 日本薬学会年会要旨集(Web). 2025. 145th
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Patents (2)：
Books (5)：
  • 薬学のための分子生物学
    廣川書店 2014
  • Methods in Neuroethological Research
    Springer 2013 ISBN:4431543309
  • Mechanisms of cancer prevention with curcumin and (-) epicatechin: in lung cancer cells with regard to expression of growth arrest and DNA?damage inducible genes, GADD45 and GADD153
    LAP LAMBERT Academic Publishing 2011 ISBN:3844316426
  • 生物薬科学実験講座タンパク質
    廣川書店 2008
  • 薬学領域の生化学
    廣川書店 2007
Lectures and oral presentations  (6)：
  • インフルエンザウイルスRNAポリメラーゼ
    (第8回 HBS 公開シンポジウム 2011)
  • New aspects of green tea catechins in relation to DNA and RNA molecules
    (ICPH2007 -3rd International Conference on Polyphenols and Health 2007)
  • DNA and RNA as New Biological Reservoirs of Green tea catechins
    (The 8th Japan-Korea Joint Symposium on Cancer and Ageing Research 2007)
  • DNA AND RNA AS NEW BINDING TARGETS OF GREEN TEA CATECHIN
    (Seventh International Skin Carcinogenesis Conference 2006)
  • 緑茶成分カテキンはDNAやRNAと直接結合する。
    (第1回食品薬学シンポジウム 2006)
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Education (4)：
  • 1991 - 1993 東京大学大学院 薬学系研究科生命薬学専攻 博士課程
  • 1989 - 1991 東京大学大学院 薬学系研究科生命薬学専攻 修士課程
  • 1987 - 1989 The University of Tokyo Faculty of Pharmaceutical Sciences
  • 1985 - 1987 The University of Tokyo
Professional career (1)：
  • Ph.D.
Work history (5)：
  • 2008/04 - 現在 Tokushima Bunri University Faculty of Pharmaceutical Sciences
  • 2007/04 - 2008/03 Tokushima Bunri University Faculty of Pharmaceutical Sciences
  • 2005/04 - 2007/03 Tokushima Bunri University Faculty of Pharmaceutical Sciences
  • 1993/10 - 2005/03 The University of Tokyo Institute of Molecular and Cellular Biosciences
  • 1992/01 - 1993/09 日本学術振興会・特別研究員(DC1)
Association Membership(s) (5)：
アメリカ微生物学会 ,  薬学会 ,  生物物理学会 ,  分子生物学会 ,  生化学会
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