Higashi Tatsuya

ヒガシタツヤ | Higashi Tatsuya

Affiliation and department：

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (1)： Analytical and Bioanalytical Chemistry

Research theme for competitive and other funds (18)：

2020 - 2023 Development of enhanced throughput LC/MS assays of steroid hormones based on sample and analyte-multiplexing
2018 - 2020 臨床検査応用を目指したLC-MS/MS定量測定法の開発と基盤技術の構築
2017 - 2020 Development of derivatization procedures using reagent analogues and isotopologues for enhancing throughput of mass spectrometry-based clinical examinations
2015 - 2018 Development of the quantitative measurement methods by LC-MS/MS for clinical laboratory applications.
2015 - 2017 Development of LC-MS/MS-based accurate quantification methods for assessing serum vitamin D metabolites

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Papers (159)：

Tatsuya Higashi, Asuka Tanaka, Shiho Tsubura, Shoichi Nishimoto-Kusunose. Conversion of 5α-Androstane-3α,17β-diol to bis[(4-dimethylamino)phenyl carbamate] derivative for sensitive determination of its rat brain level by LC/ESI-MS/MS. Rapid Communications in Mass Spectrometry. 2024. 38. 19
H. Matsuoka, H. Kaneko, T. Narita, T. Ishige, T. Higashi. Sensitive analysis of triiodothyronine in serum by one-step multiple methylations followed by LC/ESI-MS/MS. Chromatography. 2024. 45. 2. 85-89
T. Higashi. Derivatization to generate a product ion containing analyte-specific moiety in ESI-MS/MS. ANALYTICAL SCIENCES. 2024. 40. 6. 973-974
T. Shibuya, A. Sato, S. Nishimoto-Kusunose, K. Yoshizawa, T. Higashi. Further evidence for blood-to-brain influx of unconjugated bile acids by passive diffusion: Determination of their brain-to-serum concentration ratios in rats by LC/MS/MS. STEROIDS. 2024. 204. 109397
Yuka Mizumoto, Ayaka Hirakawa, Yuki Sugiura, Tetsuo Nishikawa, Koshiro Nishimoto, Yasunari Mano, Tatsuya Higashi. Determination of three C18-oxygenated steroids in adrenal lesion segments in primary aldosteronism by super-selective adrenal venous sampling and LC/ESI-MS/MS. Biomedical chromatography : BMC. 2024. e5841

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MISC (31)：

水元優花, 平川彩夏, 楠瀬翔一, 杉浦悠毅, 西本紘嗣郎, 東達也. Quantification of C18-oxygenated steroids in adrenal tributary venous serum of patients with primary aldosteronism LC/ESI-MS/MS. 日本薬学会年会要旨集(Web). 2023. 143rd
高田一成, 萩原雪乃, 冨樫萌香, 橘高敦史, 川越文裕, 上杉志成, 上杉志成, 楠瀬翔一, 東達也. 23,25-ジヒドロキシビタミンD₃:β-グルクロニダーゼ処理したヒト尿中の主要なビタミンD₃代謝物. 次世代を担う若手のためのフィジカル・ファーマフォーラム講演要旨集. 2022. 19th
帆保航, 小八木冴, 太田有紗, 楠瀬翔一, 小川祥二郎, 小川祥二郎, 杉浦悠毅, 東達也. Development of derivatization-based 6-plex LC/ESI-MS/MS assay for determination of aldosterone in adrenal tributary venous serum using 6 Girard reagents. 日本薬学会年会要旨集(Web). 2021. 141st
帆保航, 城彰宏, 小八木冴, 小川祥二郎, 小川祥二郎, 楠瀬翔一, 東達也. A method for determination of hexanoylglycine concentrations of 3 urine samples during a single LC/ESI-MS/MS run using DEAPPZ isotopologues. バイオメディカル分析科学シンポジウム講演要旨集. 2021. 33rd
平川彩夏, 田中あすか, 楠瀬翔一, 吉澤一巳, 東達也. Development of a method for screening of agents promoting allopregnanolone biosynthesis using C6 cells and LC/ESI-MS/MS. JSBMS Letters. 2021. 46. Supplement

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Patents (25)：

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Books (7)：

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Lectures and oral presentations (172)：

新規Cookson型誘導体化試薬とLC/ESI-MS/MSを用いた,ヒト尿中23,25-ジヒドロキシビタミンD3-グルクロニドの抱合位置決定
(日本薬学会第144年会 2024)
エストラジオールの骨格由来の特異的プロダクトイオンを生成する誘導体化法とそれを用いた血中エストラジオールのLC/ESI-MS/MS定量法の開発
(日本薬学会第144年会 2024)
LC/ESI-MS/MS によるラット脳内非抱合型胆汁酸の一斉分析法の開発と由来解析
(第34回クロマトグラフィー科学会議 2023)
エストラジオール骨格を含む特異的プロダクトイオンを生成する誘導体化法とそれを用いた血中エストラジオールの高精度LC/ESI-MS/MS定量法
(第48回日本医用マススペクトル学会年会 2023)
ステロイドのLC/ESI-MS/MS用誘導体化試薬の開発
(日本医用マススペクトル学会第8回東部会 2023)

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Works (1)：

Development of analytical procedure for detrtmination of 1a-hydroxyvitamin D3 in human plasma
2000 -

Education (2)：

Professional career (1)：

Work history (9)：

2011 - 現在 Tokyo University of Science Faculty of Pharmaceutical Sciences
2009 - 2011 University of Shizuoka School of Pharmaceutical Sciences
2007 - 2009 同准教授
2004 - 2007 Kanazawa University Graduate School of Natural Science and Technology
2003 - 2004 同助教授

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Committee career (15)：

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Awards (2)：

Association Membership(s) (4)：

日本薬学会 , 日本医用マススペクトル学会 , 日本分析化学会 , クロマトグラフィー科学会

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