Rchr

J-GLOBAL ID：200901020977429020 Update date: Feb. 28, 2024

nakai junichi

ナカイジュンイチ | nakai junichi

Affiliation and department：
Job title：教授

Research field (3)： Neuroscience - general , Clinical pharmacy , Physiology

Research keywords (18)：包括脳ネットワーク , 統合脳・神経回路機能 , 海馬 , カルシウム放出チャンネル , ニューロン , 神経回路 , 蛍光 , カルシウム放出チャネル , ジヒドロピリジン受容体 , 電位依存性カルシウムチャネル , カルシウム , バイオセンサー , cDNA発現 , 分子生物学 , カルシウムチャネル , GFP , 興奮収縮連関 , リアノジン受容体

Research theme for competitive and other funds (48)：

2023 - 2028 Novel molecular mechanism of oral cancer pain focused attention on plastic changes in intercellular network in the trigeminal ganglion
2021 - 2025 マルチスケール脳機能イメージングによる神経障害性疼痛の情動変容機序の解明
2020 - 2023 Study on neural mechanism of swallowing by imaging
2016 - 2021 System Identification of Bio-Navigation and Development of Innovative Logging Device
2015 - 2020 Development of Fluorescent Probes with Molecular Evolution Engineering

2015 - 2018 New development of clarification and control on mechanism of neurogenesis of fluorescent enteric neurons responding to stimuli.

2014 - 2018 Study of neuronal network mechanism for habit learning using highly sensitive calcium probe

2015 - 2017 A study of neural circuit mechanism of voluntary behavior in C. elegans

2014 - 2016 運動学習における長期記憶機構の研究

2013 - 2016 Development of whole heart calcium imaging system with two different waves using modified G-CaMP-DsRed-coexpressed transgenic rat model in the blood-perfused excised heart preparation

2013 - 2016 Development of novel molecular probes toward bio-imaging and photopharmacology of neural systems

2012 - 2016 Toward Brain Census: Construction of a method for revealing the memory mechanism at the molecular level

2014 - 2015 Development of a fast photo-stimulation device

2013 - 2015 蛍光プローブによる細胞移動の予測と移動秩序の分子機構の解明

2013 - 2015 Imaging analysis of neural circuit involved in voluntary behaviors in C. elegans

2011 - 2015 Clarification and control on mechanism of neurogenesis of fluorescent enteric neurons.

2013 - 2014 Next generation photostimulation system using tunable laser

2012 - 2014 Looking into living enteric neurons

2012 - 2014 Functional analyses of newborn neurons in CNS by Cereblon overexpression

2012 - 2012 Development of a next-generation photo-stimulation device

2010 - 2012 NETWORK ANALYSIS AMONG HARD TISSUE CELLS USING MULTI-PHOTON MICROSCOPE

2010 - 2012 Functional study of Munc18 mutations associated with epilepsy

2010 - 2012 STUDY OF SYNAPTIC MODULATORY MECHANISMS IN RESPONSE TO STRESS MEDIATED BY 5-HT2A RECEPTOR

2009 - 2009 ゼブラフィッシュの覚醒・睡眠の分子機構に関する研究

2009 - 2009 Development of a red fluorescent Ca^<2+> sensor

2005 - 2005 ケージドグルタミン酸を用いた多点同時刺激による海馬ニューロンの長期増強の解析

2003 - 2004 グルタミン酸受容体のリン酸化と神経回路形成の分子生物学的研究

2002 - 2003 Development of CFP-based calcium probes that emit blue fluorescence

2001 - 2002 DEVELOPMENT OF VOLTAGE-SENSING FLUORESCENT PROTEIN BASED ON GFP

2001 - 2002 Rho蛋白質と神経細胞のリモデリングに関する研究

2000 - 2001 蛋白性蛍光センサープローブによるショウジョウバエ脳の情報処理経路の研究

1999 - 2000 Dynamic analysis of subcellular ionic signalling in neurons

1999 - 2000 EXCITATION-CONTRUCTION COUPLING AND TETRAD STRUCTURE OF L-TYPE CACLIUM CHANNEL.

1999 - 1999 ショウジョウバエ脳の知覚情報処理経路の研究

1997 - 1998 Production & analysis of Ca^<2+> channel subunit-defecient mice.

1997 - 1998 Protein-protein interaction between voltage-gateal calcium channel and ryanodine recegtor.

1997 - 1997 興奮収縮連関におけるリアノジン受容体の構造と機能の研究

1996 - 1996 Studies on molecular mechanism of neural calcium signaling

1996 - 1996 電位依存性カルシムチャネルの不活性化機構と不整脈の研究

1996 - 1996 カルシウムチャネル、カルシウムATPaseおよびリアノジン受容体の機能協関

1993 - 1993 Studies on the molecular mechanism for calcium signaling

1992 - 1992 Studies on the structural basis for ion channel functions

1992 - 1992 興奮収縮連関の分子機構に関する研究

1990 - 1991 イオンチャンネルの立体構造と作用機序に関する研究

モデル生物(線虫等)を用いた研究

functional neuronal network study

カルシウムイオン濃度測定

神経回路機能の研究

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Papers (95)：

Kanako Tominami, Tada-aki Kudo, Takuya Noguchi, Yohei Hayashi, You-Ran Luo, Takakuni Tanaka, Ayumu Matsushita, Satoshi Izumi, Hajime Sato, Keiko Gengyo-Ando, et al. Physical Stimulation Methods Developed for In Vitro Neuronal Differentiation Studies of PC12 Cells: A Comprehensive Review. International Journal of Molecular Sciences. 2024. 25. 2. 772-772
Nobuhiro Nakai, Masaaki Sato, Okito Yamashita, Yukiko Sekine, Xiaochen Fu, Junichi Nakai, Andrew Zalesky, Toru Takumi. Virtual reality-based real-time imaging reveals abnormal cortical dynamics during behavioral transitions in a mouse model of autism. Cell reports. 2023. 112258-112258
Keiko Gengyo-Ando, Minoru Tateyama, Shohei Mitani, Hideki Ando, Junichi Nakai. A humanized Caenorhabditis elegans model for studying pathogenic mutations in VPS45, a protein essential for membrane trafficking, associated with severe congenital neutropenia. microPublication biology. 2023. 2023
You-Ran Luo, Tada-aki Kudo, Kanako Tominami, Satoshi Izumi, Takakuni Tanaka, Yohei Hayashi, Takuya Noguchi, Atsushi Matsuzawa, Junichi Nakai, Guang Hong, et al. SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells. International Journal of Molecular Sciences. 2022. 23. 24. 15602-15602
Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hirai. Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo. Communications Biology. 2022. 5. 1

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MISC (144)：

Hiroki Sugimoto, Masaaki Sato, Junichi Nakai, Kiyoshi Kawakami. Astrocytes in Atp1a2-deficient heterozygous mice exhibit hyperactivity after induction of cortical spreading depression. FEBS open bio. 2020. 10. 6. 1031-1043
今泉美佳, 青柳共太, 吉田昌史, 飛田耶馬人, 大倉正道, 山内肇, 崎村建司, 中井淳一, 加計正文, 永松信哉, et al. 甦れβ細胞よ! 女性研究者が糖尿病を克服するアクティブゾーンタンパク質ELKSのインスリン分泌における役割. 糖尿病. 2018. 61. Suppl.1. S-68
Masaaki Sato, Yuki Motegi, Keiko Gengyo-Ando, Masamichi Ohkura, Junichi Nakai. Ultra-deep brain imaging with a novel two-photon varifocal microendoscope. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S135-S135
大倉正道, 中井淳一. 高性能な赤色蛍光Ca2+プローブタンパク質 (特集革新的ライフサイエンスの展望). 化學工業. 2016. 67. 7. 489-496
茂木優貴, 茂木優貴, 安藤恵子, 安藤恵子, 沖篤志, 沖篤志, 岩井陽一, 毛内拡, 平瀬肇, 平瀬肇, et al. G-CaMP7発現マウスを用いた大脳皮質神経活動のミクロ,マクロ解析法. 日本生理学雑誌(Web). 2016. 78. 3

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Patents (2)：

Method of producing a biosensor protein capable of regulation a fluorescence property of Green Fluorescent Protein, and the biosensor protein produced by the method.
緑色蛍光蛋白質の蛍光強度を効率的に制御する方法と緑色蛍光蛋白を用いたバイオセンサーの遺伝子の開発

Books (1)：

ニューロンの生理学
京都大学学術出版会 2009

Professional career (1)：

- (Kyoto Univ.)

Work history (7)：

2019/04 - 現在 Tohoku University Graduate School of Dentistry, Oral physiology professor
2009/02 - 2019/03 Saitama University
2008/04 - 2009/01 RIKEN
2004/06 - 2008/03 RIKEN
2003/04 - 2004/05 RIKEN

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