Nikawa Takeshi

2019 - 2022 Exosome-mediated muscle atrophy and new therapeutic approaches for cancer cachexia

2019 - 2022 Mechano-nutrition-signaling for disuse muscle atrophy

2016 - 2022 筋萎縮の病態に迫るミトコンドリアのメカノバイオロジー

2017 - 2020 ユビキチン-プロテアソーム系制御による廃用性筋萎縮抑制法の開発

2018 - 2020 Sensing system of microgravity in muscle mitochondria

2016 - 2019 次世代の宇宙栄養学研究者育成のための国際拠点形成

2014 - 2019 運動・身体機能維持を促す次世代機能性食品の創製

2015 - 2018 血管新生阻害治療の盲点:大腸癌細胞の新たな環境適応機構とその制御法の開発

2016 - 2018 Identification of mitochondrial aconitase as a critical enzyme sensitive to microgravity stress

2015 - 2018 Molecular rehabilitation of mitochondrial function towards preventing muscle atrophy

2014 - 2017 Development of the treatment of the skeletal muscle atrophy through the IGF-1 signaling in the growth period

2014 - 2017 Effect of functional marine flavonoid on muscle atrophy

2015 - 2017 抗老化たん白質源としての大豆たん白質食の臨床試験~ホエイたん白質食との相乗効果~

2013 - 2016 宇宙飛行士の安全な長期宇宙滞在を可能にする機能性宇宙食の開発

2013 - 2015 Countermeasure against muscle atrophy: a new concept approach on cell signaling regulation 廃用性筋萎縮予防に効果のある新規バイオマテリアルの有用性検証

2012 - 2015 Identification of novel proteases involved in the regulation of highly pathogenic avian influenza (HPAI) viruses infection

2012 - 2015 Mitochondria is a key signal inducer for unloading stress toward muscle atrophy

2013 - 2014 Molecular genetic analysis of atherosclerosis and atrial thrombosis rat model spontaneously induced by hypoactivity

2010 - 2013 Pathological analysis for loss ofmuscle contraction after tendon transfer surgery

2008 - 2013 筋肉老化を防ぐユビキチン化ペプチドおよびフラボノイドの開発

2011 - 2012 廃用性筋萎縮治療薬としてのユビキチン化酵素阻害剤の開発

2011 - 2012 Rapid screening of gene(s) related to the phenotype of model rats with high levels of voluntarily wheel running activity

2009 - 2012 Molecular mechanisms of muscle mass regulation : Identification of a novel protease involved in myostatin activation.

2008 - 2012 Basic research on the integrated regulation of locomotive function

2009 - 2011 骨格筋萎縮を予防する抗ユビキチン化オリゴペプチドの開発

2008 - 2011 新規筋代謝マーカーの確立-運動療法の実効度・リスク度の簡易評価法の開発-

2008 - 2011 Enhancement of bone healing during distraction osteogenesis

2009 - 2011 Medium chain fatty acid regulates uncoupling protein 3 expression in skeletal muscle

2007 - 2009 筋ジス治療薬としてのエピガロカテキンガレートの適格性と分子作用機序の研究

2007 - 2009 Molecular meohanisms of mechanosensing inskeletal muscles : Based on regulation system of atrogen expression

2006 - 2008 Development of oligopeptides against skeletal muscle fatigue and atrophy caused by unloading

2006 - 2008 Musculo-skeletal regeneration during distracionosteogenesis

2005 - 2007 Thrombin and mast cell tryptase are trigger proteases in arthritis.

2005 - 2007 Characterization of a cerebellar ubiquitin ligase, which mediates effects of training to nerve

2004 - 2006 Does the collagen IX tryptophan polymorphism trigger lumbar disc degeneration?

2004 - 2006 A muscle secreting protein attractin regulates expression of UCP-2 in adipocytes.

2004 - 2006 Modulation of Bone Remodeling during Distraction Osteogenesis

2003 - 2005 Clarification of the pathophysiological significance of mast cell tryptase and protease activated receptor-2 (PAR-2) in articular destruction

2003 - 2005 Design, synthesis and property of peptide mimics having inhibition effect of reducing musclar strength

2003 - 2005 Molecular mechanism of unloading-mediated insulin resistance

2005 - 機械的ストレスの感知機構

2002 - 2004 無重力環境における骨萎縮の分子メカニズム

2002 - 2004 BONE REMODELING IN THE CALLUS FORMED DURING -DISTRACTION OSTEOGENESIS

2001 - 2003 Inhibition of N-end rule-dependent proteolysis by dipeptide

2001 - 2003 Development of novel nutritional methods to inhibit muscle atrophy caused by microgravity.

1999 - 2001 Abmormal expression of mitochondrial gene in disuse-induced muscle atrophy

2001 - 寝たきりや老化による運動器(筋・骨)の萎縮に有効な新規栄養法の開発

1998 - 2000 IL-5受容体欠損マウスを用いた小腸粘膜でのIL-5とビタミンAの相互作用の解析

1996 - 1998 Synergistic effects of retinoic acid and IL-1beta on expression of the bone-type alkaline phsphatase and retinoid receptors in small intestinal epithelial cells.

1998 - 廃用性筋萎縮の分子メカニズムとその治療法の開発

1996 - 1997 脳微小透析法による非特異的栄養素摂取調節機構の解明

1995 - 1996 運動による筋傷害の成因とその予防に対する栄養学的アプローチ

無重力下の筋蛋白質及び骨カルシウム代謝とプロテアーゼ

Nutrition and the immune system in intestine

Possible involvement of cysteine proteases in muscle degradation and bone resorption under experimental hypogravity condition

Proliferation and differentiation of gastointestinal epithelial cells.