Ichimura Yoshinobu

イチムラヨシノブ | Ichimura Yoshinobu

Affiliation and department：
Job title： Associate Professor

Research field (1)： Cell biology

Research theme for competitive and other funds (6)：

2020 - 2023 選択的オートファジーレセプターp62のリン酸化制御機構とその生理的意義の解明
2016 - 2019 Study on molecular mechanism of p62-Keap1-Nrf2 system
2013 - 2016 Phosphorylation of p62/Sqstm1 activates Nrf2 during selective autophagy
2010 - 2012 Molecular mechanisms of p62 degradation in selective autophagy
2006 - 2007 The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy

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Papers (42)：

Ryo Ikeda, Daisuke Noshiro, Hideaki Morishita, Shuhei Takada, Shun Kageyama, Yuko Fujioka, Tomoko Funakoshi, Satoko Komatsu-Hirota, Ritsuko Arai, Elena Ryzhii, et al. Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response. The EMBO journal. 2023. e113349
Daisuke Yasuda*, Ippei Yoshida, Riyo Imamura, Daiki Katagishi, Kyoko Takahashi, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Tadahiko Mashino, et al. Development of p62-Keap1 Protein-Protein Interaction Inhibitors as Doxorubicin-Sensitizers Against Non-Small Cell Lung Cancer. Results in Chemistry. 2022. 4. 100609
Mohammad Omar Faruk, Yoshinobu Ichimura, Shun Kageyama, Satoko Komatsu-Hirota, Afnan H El-Gowily, Yu-Shin Sou, Masato Koike, Nobuo N Noda, Masaaki Komatsu. Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. The Journal of biological chemistry. 2021. 297. 6. 101405-101405
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, et al. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nature Communications. 2021. 12. 1
Maruyama, T, Alam, J. M, Fukuda, T, Kageyama, S, Kirisako, H, Ishii, Y, Shimada, I, Ohsumi, Y, Komatsu, M, Kanki, T, et al. Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis. Nature Structural & Molecular Biology. 2021. 28. 7. 583-593

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MISC (22)：

Mohammad Omar Faruk, Yoshinobu Ichimura, Masaaki Komatsu. Selective autophagy. Cancer Science. 2021. 112. 10. 3972-3978
中島真央, 安田大輔, 大江知之, 高橋恭子, 小松雅明, 一村義信, 今村理世, 小島宏建, 岡部隆義, 長野哲雄, et al. 医薬品としての物性向上を目指したKeap1-リン酸化p62結合阻害剤の創製. 日本薬学会年会要旨集. 2018. 138年会. 2. 114-114
中島真央, 安田大輔, 大江知之, 高橋恭子, 小松雅明, 一村義信, 今村理世, 小島宏建, 岡部隆義, 長野哲雄, et al. 医薬品としての物性向上を目指したKeap1-リン酸化p62結合阻害剤の創製. 日本薬学会年会要旨集. 2018. 138年会. 2. 114-114
高橋俊作, 一村義信, 小松雅明. 【オートファジー〜胆膵疾患とのかかわりについて〜】オートファジーと疾患とのかかわり. 胆と膵. 2018. 39. 2. 111-116
一村義信, 小松雅明. p62/Sqstm1のKeap1相互作用領域をリン酸化するキナーゼのスクリーニング. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [2P-026]

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Professional career (3)：

学士(工学) (崇城大学)
修士(工学) (崇城大学)
博士(理学) (総合研究大学院大学)

Work history (1)：

2019/04 - 現在 Juntendo University Department of Pysiology, School of Medicine Associate Professor

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