Rchr
J-GLOBAL ID：200901021890000113   Update date: Jul. 11, 2024

Sakamoto Seiji

サカモト セイジ | Sakamoto Seiji
Affiliation and department：
Kyoto University Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering

About Kyoto University Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering


Job title： Specialized Associate Professor
Research field  (1)： Molecular biochemistry
Research keywords  (3)： ペプチド化学 ,  タンパク質 ,  Protrin and peptide chemistry
Research theme for competitive and other funds  (10)：
  • 2023 - 2026 内在性GABA(A)受容体のケミカルラベルを基軸とする薬剤アッセイ系の構築
  • 2020 - 2023 特異的化学修飾を基軸とする内存性GABA(A)受容体のバイオセンサー化
  • 2014 - 2017 Development of New Strategy of Protein Design Based on Single Phage Sorting Technique
  • 2013 - 2015 Design of Detection System for Histone Modification Patterns Using Split-Proteins
  • 2012 - 2015 Supramolecular Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate with Proteins and Protein-Polymer Hybrids as Chiral Reaction Medias
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Papers (55)：
  • Hiroshi Nonaka, Seiji Sakamoto, Kazuki Shiraiwa, Mamoru Ishikawa, Tomonori Tamura, Kyohei Okuno, Takumi Kondo, Shigeki Kiyonaka, Etsuo A. Susaki, Chika Shimizu, et al. Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains. Proceedings of the National Academy of Sciences. 2024. 121. 6
  • Hugo R. Arias, Philippe De Deurwaerdère, Petra Scholze, Seiji Sakamoto, Itaru Hamachi, Giuseppe Di Giovanni, Abdeslam Chagraoui. Coronaridine congeners induce sedative and anxiolytic-like activity in naïve and stressed/anxious mice by allosteric mechanisms involving increased GABAA receptor affinity for GABA. European Journal of Pharmacology. 2023. 953. 175854-175854
  • Hugo R. Arias, Spencer R. Pierce, Allison L. Germann, Sophia Q. Xu, Marcelo O. Ortells, Seiji Sakamoto, Dina Manetti, Maria Novella Romanelli, Itaru Hamachi, Gustav Akk. Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAAReceptor. Molecular Pharmacology. 2023. 104. 3. 115-131
  • Hiroshi Nonaka, Takeharu Mino, Seiji Sakamoto, Jae Hoon Oh, Yu Watanabe, Mamoru Ishikawa, Akihiro Tsushima, Kazuma Amaike, Shigeki Kiyonaka, Tomonori Tamura, et al. Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes. Chem. 2023. 9. 2. 523-540
  • Hugo R. Arias, Allison L. Germann, Spencer R. Pierce, Seiji Sakamoto, Marcelo O. Ortells, Itaru Hamachi, Gustav Akk. Modulation of the mammalian GABAA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor. British Journal of Pharmacology. 2022. 179. 24. 5323-5337
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MISC (15)：
  • Takeharu Mino, Hiroshi Nonaka, Seiji Sakamoto, Jae Hoon Oh, Itaru Hamachi. Protocol to visualize the distribution of exogenously administered small molecules in the mouse brain. STAR Protocols. 2023. 4. 3. 102555-102555
  • Seiji Sakamoto, Itaru Hamachi. Ligand-Directed Chemistry for Protein Labeling for Affinity-Based Protein Analysis. Israel Journal of Chemistry. 2023. 63. 3-4
  • Takeharu Mino, Seiji Sakamoto, Itaru Hamachi. Recent applications of N-acyl imidazole chemistry in chemical biology. Bioscience, Biotechnology, and Biochemistry. 2021. 85. 1. 53-60
  • Seiji Sakamoto, Shigeki Kiyonaka, Itaru Hamachi. Construction of ligand assay systems by protein-based semisynthetic biosensors. Current Opinion in Chemical Biology. 2019. 50. 10-18
  • Seiji Sakamoto, Itaru Hamachi. Recent Progress in Chemical Modification of Proteins. Analytical Sciences. 2018. 35. 1. 5-27
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Lectures and oral presentations  (10)：
  • Rapid labeling strategy for endogenous glutamate receptors by a combination of in-brain ligand-directed acyl imidazole chemistry and IEDDA click reaction
    (ISBC202 2024)
  • 脳内リガンド指向性化学とクリックケミストリーの組み合わせによるグルタミン酸受容体の高速ラベル化戦略
    (日本化学会 第104春季年会 2024)
  • Ligand directed chemistry in live mouse brain (2): 様々な神経伝達物質受容体への拡張と寿命解析
    (日本化学会 第102春季年会 2022)
  • 内存性GABA(A) 受容体のマウス脳内固定化駆動ケミカルラベリング
    (日本化学会 第101春季年会 2021)
  • リガンド指向性化学による内存性GABA(A)受容体の選択的ケミカルラベリング
    (2020)
ｍore...
Education (4)：
  • - 1999 Tokyo Institute of Technology Bioscience and Biotechnology
  • - 1999 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering Department of Riotechnology
  • - 1994 Nagasaki University Faculty of Engineering
  • - 1994 Nagasaki University Faculty of Engineering Faculty of Applied Chemistry
Professional career (1)：
  • Doctor(Engineering) (Tokyo Institute of Technology)
Work history (7)：
  • 2022/01 - 現在 Kyoto University Graduate School of Engineering
  • 2017/11 - 2021/12 Kyoto University Graduate School of Engineering
  • 2017/05 - 2017/10 Kyoto University Graduate School of Engineering
  • 2008/04 - 2017/04 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Assistant Professor
  • 2007/04 - 2008/03 The University of Tokyo Institute of Industrial Science Assistant Professor
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Association Membership(s) (3)：
高分子学会 ,  日本ペプチド学会 ,  日本化学会
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