MASATO MARUYAMA

Affiliation and department：

Research field (1)： Clinical pharmacy

Research theme for competitive and other funds (15)：

2017 - 現在グリオーマ癌幹細胞特異的に発現する新規バイオマーカーの機能解析
2017 - 現在グリオーマ癌幹細胞特異的に発現する新規バイオマーカーの機能解析
2020 - 2025 Effect of ENS dysfunction on drug absorption from small intestine
2020 - 2023 Establishment of a novel drug delivery system for targeting cancer stem cells based on the structual analysis of tumor blood vesseles.
2017 - 2020 Funcional analysis of a novel biomarker specifically expressed in glioma stem cell.

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Papers (51)：

Masato Maruyama, Reiya Torii, Hazuki Matsui, Hiroki Hayashi, Ken-ichi Ogawara, Kazutaka Higaki. Repeated sequential administration of pegylated emulsion of SU5416 and liposomal paclitaxel enhances anti-tumor effect in 4T1 breast cancer-bearing mice. European Journal of Pharmaceutics and Biopharmaceutics. 2025. 209. 114663-114663
Saki Nishiyama, Yuki Takemoto, Keita Yamanouchi, Keiji Kondo, Sho Kawatsu, Masato Maruyama, Kazutaka Higaki. Dynamic changes in the distribution equilibrium of drugs in microemulsions associated with drug absorption facilitate the absorption improvement for drugs with low water-solubility by self-microemulsifying drug delivery system (SMEDDS). International Journal of Pharmaceutics. 2025. 125458-125458
Masato Maruyama, Tomoki Ueda, Yusuke Ienaka, Haruka Tojo, Kenji Hyodo, Ken-ichi Ogawara, Kazutaka Higaki. EGF-induced P-gp expression in tumor vasculature contributes to therapeutic resistance to Doxorubicin-PEG-liposomes in mice bearing Doxorubicin-resistant B16-BL6 tumors. Journal of Drug Delivery Science and Technology. 2025. 106690-106690
Shohei Aikawa, Hironori Tanaka, Hiroshi Ueda, Masato Maruyama, Kazutaka Higaki. Specific intermolecular interaction with sodium glycocholate generates the co-amorphous system showing higher physical stability and aqueous solubility of Y5 receptor antagonist of neuropeptide Y, a brick dust molecule. European Journal of Pharmaceutics and Biopharmaceutics. 2024. 202. 114395-114395
Masato Maruyama, Hazuki Matsui, Haruka Nakamura, Reiya Torii, Yuta Takasugi, Ken-ichi Ogawara, Kazutaka Higaki. Vascular normalization with pegylated emulsion of SU5416 enhances anti-tumor effect of liposomal paclitaxel in 4T1 breast cancer-bearing mice: Analysis of intratumoral vessels and microenvironment. Journal of Drug Delivery Science and Technology. 2024. 96. 105647

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MISC (18)：

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Books (1)：

Aminopeptidase Q/Laveverin「Handbook of Proteolytic Enzymes」
Academic Press 2013 ISBN:9780123822192

Lectures and oral presentations (65)：

血管新生阻害剤SU-5416による血管正常化療法ががん関連繊維芽細胞に及ぼす影響
(第38回日本DDS学会学術集会 2022)
マウス乳がん由来4T1細胞におけるがん幹細胞様のモデル細胞株樹立に関する研究
(第38回日本DDS学会学術集会 2022)
血管新生阻害剤 SU5416 - パクリタキセル (PTX) 内封 PEG リポソームの逐次的頻回併用療法の転移性乳がん4T1担がんマウスにおける抗腫瘍効果
(日本薬剤学会第37年会 2022)
ドキソルビシン(DOX)耐性腫瘍に対するDOX-PEGリポソームの抗腫瘍効果に及ぼす腫瘍組織内血管内皮細胞特性の影響
(日本薬剤学会第37年会 2022)
難水溶性薬物ClofazimineのSelf-nanoemulsifying Drug Delivery System(SNEDDS)による経口吸収挙動改善機構の解析
(日本薬剤学会第37年会 2022)

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Professional career (1)：

PhD (Kyoto University)

Awards (1)：

2006/08 - 病態と治療におけるプロテアーゼとインヒビター研究会ポスター奨励賞

Association Membership(s) (1)：

日本薬剤学会日本薬物動態学会日本薬学会日本癌学会

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