Sugiyama Naoyuki

スギヤマナオユキ | Sugiyama Naoyuki

Affiliation and department：
Job title： Laboratoty Chief
Other affiliations (1)：

Research field (1)： Systems genomics

Research keywords (3)： Proteomics , The Chemistry of natural products , 天然有機化合物

Research theme for competitive and other funds (16)：

2021 - 2024 Comprehensive profiling of substrate recognition motifs for human kinome
2020 - 2022 Development of the method for determination of kinome activity by monitoring regulatory site-containing peptides
2018 - 2020 Elucidation of Regulation Mechanism of Kinome Functions
2016 - 2020 Development of safety evaluation system for DDS carrier based on network toxicology
2016 - 2019 Phosphorylation netowork analysis based on in vitro kinase-substrate relationships

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Papers (76)：

Saashia Fuji, Shota Yamauchi, Naoyuki Sugiyama, Takayuki Kohchi, Ryuichi Nishihama, Ken-ichiro Shimazaki, Atsushi Takemiya. Light-induced stomatal opening requires phosphorylation of the C-terminal autoinhibitory domain of plasma membrane H+-ATPase. Nature Communications. 2024. 15. 1
Tomoya Niinae, Naoyuki Sugiyama, Yasushi Ishihama. Validity of the cell-extracted proteome as a substrate pool for exploring phosphorylation motifs of kinases. Genes to cells : devoted to molecular & cellular mechanisms. 2023. 28. 10. 727-735
Yuki Narukawa, Naoyuki Sugiyama, Jiro Miura, Rentaro Yamashita, Shotaro Tominaga, Yoshihiro Izumi, Takeshi Bamba, Yasushi Ishihama, Yoichiro Kashiwagi, Shinya Murakami. Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium. Journal of periodontal research. 2023. 58. 4. 813-826
Kosuke Ogata, Shunsuke Takagi, Naoyuki Sugiyama, Yasushi Ishihama. Motif-Targeting Phosphoproteome Analysis of Cancer Cells for Profiling Kinase Inhibitors. Cancers. 2022. 15. 1. 78-78
Keiichirou Nemoto, Tomoya Niinae, Fumina Goto, Naoyuki Sugiyama, Aiko Watanabe, Motoki Shimizu, Katsuhiro Shiratake, Masahiro Nishihara. Calcium-dependent protein kinase 16 phosphorylates and activates the aquaporin PIP2;2 to regulate reversible flower opening in Gentiana scabra. The Plant cell. 2022. 34. 7. 2652-2670

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MISC (262)：

前田朝登, 小形公亮, 杉山直幸, 石濱泰. Sensing protein conformational changes by in vitro phosphorylation tagging. 日本薬学会年会要旨集(Web). 2022. 142nd
花田毅己, 金尾英佑, 金尾英佑, 村岡賢, 李優嘉, 新苗智也, 今見考志, 杉山直幸, 足立淳, 足立淳, et al. Large-scale discovery of BRAF substrates by proteomic approaches. 日本薬学会年会要旨集(Web). 2022. 142nd
工藤拓実, 山下蓮太郎, WU Pei-Shan, 杉山直幸, 石濱泰. High-speed taxonomy profiling by proteomics approaches. 日本薬学会年会要旨集(Web). 2022. 142nd
中井郁那, 富岡亮太, 杉山直幸, 小形公亮, 石濱泰. Development of High-Sensitivity/High-Throughput Proteomics Systems for Minute Sample Analysis. 質量分析総合討論会講演要旨集. 2022. 70th
李優嘉, 新苗智也, 今見考志, 杉山直幸, 石濱泰. Proximity-labeling proteomic approach to investigate the molecular determinants underlying the exosome uptake into cells. 日本薬学会年会要旨集(Web). 2021. 141st

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Patents (4)：

Books (5)：

Lectures and oral presentations (26)：

ボトムアップ法によるリン酸化プロテオフォーム解析と課題
(日本プロテオーム学会2023年大会 2023)
ヒトキノーム活性計測および予測法の開発
(日本プロテオーム学会2022年大会 2022)
リン酸化プロテオミクスを応用したキノーム活性評価法の開発
(第29回クロマトグラフィーシンポジウム 2022)
Large-Scale Discovery of In Vitro Substrates of Human Kinome Using Phosphoproteomics
(MBSJ2020 Online 2020)
In Vitro Human Kinome Profiling Using Phosphoproteomic Approaches
(The 68th Annual Conference on Mass Spectrometry 2020)

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Education (3)：

1998 - 2003 The University of Tokyo Graduate School of Science Department of Chemistry
1996 - 1998 The University of Tokyo Faculty of Science Department of Chemistry
1994 - 1996 The University of Tokyo

Professional career (1)：

Work history (6)：

2024/04 - 現在 National Cerebral and Cardiovascular Center Omics Research Center Laboratory Chief
2013/01 - 2024/03 Kyoto University Graduate School of Pharmaceutical Sciences Associate Professor
2011/04 - 2012/12 Keio University
2004/01 - 2011/03 ヒューマン・メタボローム・テクノロジーズ株式会社
2003/04 - 2003/11 科学技術振興事業団 CREST研究員

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Awards (1)：

Association Membership(s) (6)：

日本生化学会 , クロマトグラフィー科学会 , 日本薬学会 , 日本質量分析学会 , 日本プロテオーム学会 , 日本分子生物学会

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