Rchr
J-GLOBAL ID:200901022629721551   Update date: Aug. 04, 2024

Okuda Tsukasa

オクダ ツカサ | Okuda Tsukasa
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www.kpu-m.ac.jp
Research field  (4): Hematology and oncology ,  Pathobiochemistry ,  Medical biochemistry ,  Molecular biology
Research keywords  (14): RUNX1 ,  AML1 ,  tumor suppressor gene ,  oncogene ,  transcription factor ,  hematopoietic stem cell ,  leukemia ,  chromosome translocation ,  生化学 ,  血液学/腫瘍学 ,  分子生物学 ,  biochemistry ,  hematology/oncology ,  molecular biology
Research theme for competitive and other funds  (52):
  • 2022 - 2025 Establishment of new intervention methods for hematopoietic transcriptional control for clinical application.
  • 2022 - 2025 Functional analysis of transcription factors and novel SWI/SNF complexes in the tumorigenesis of rhabdoid tumors.
  • 2019 - 2022 Search for novel intervention methods for hematopoietic transcription control and research for its clinical application
  • 2019 - 2022 Elucidation of cell differentiation by hematopoietic transcription factor RUNX1 and translation to a novel molecular target strategy
  • 2019 - 2022 Elucidation of the molecular mechanisms of malignant rhabdoid tumors mediated by dysregulation of super-enhancer function.
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Papers (70):
  • Yasumichi Kuwahara, Tomoko Iehara, Akifumi Matsumoto, Tsukasa Okuda. Recent insights into the SWI/SNF complex and the molecular mechanism of hSNF5 deficiency in rhabdoid tumors. Cancer medicine. 2023
  • Haruka Shinohara, Rie Sawado, Makoto Nakagawa, Ayuna Hattori, Kazutsune Yamagata, Kimiharu Tauchi, Jumpei Ito, Yasumichi Kuwahara, Tsukasa Okuda, Chitose Ogawa, et al. Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors. Molecular Therapy - Oncolytics. 2022. 27. 14-25
  • Akifumi Matsumoto, Tatsushi Yoshida, Takahiro Shima, Kenta Yamasaki, Kenjiro Tadagaki, Noriko Kondo, Yasumichi Kuwahara, Dong-Er Zhang, Tsukasa Okuda. C11orf21, a novel RUNX1 target gene, is down-regulated by RUNX1-ETO. BBA Advances. 2022. 2. 100047-100047
  • Tatsushi Yoshida, Kenta Yamasaki, Kenjiro Tadagaki, Yasumichi Kuwahara, Akifumi Matsumoto, Adèm Sofovic, Noriko Kondo, Toshiyuki Sakai, Tsukasa Okuda. Tumor necrosis factor-related apoptosis-inducing ligand is a novel transcriptional target of runt-related transcription factor 1. International Journal of Oncology. 2021. 60. 1
  • YASUMICHI KUWAHARA, TOMOKO IEHARA, EISUKE ICHISE, YOSHIKI KATSUMI, KAZUTAKA OUCHI, KUNIHIKO TSUCHIYA, MITSURU MIYACHI, EIICHI KONISHI, HIROYASU SASAJIMA, SATOAKI NAKAMURA, et al. Novel Two MRT Cell Lines Established from Multiple Sites of a Synchronous MRT Patient. Anticancer Research. 2020. 40. 11. 6159-6170
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MISC (56):
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Books (3):
  • Role of AML1 in normal and leukemic hematopoiesis.
    Kyushu University Press(Fukuoka, Japan)・“Molecular Target for Hematological Malignancies and Cancer"(ed. by Niho, Y. ) 2000
  • ノックアウトマウス・データブック(野口 茂、平井久丸編)
    中山書店 1997
  • 造血器腫瘍アトラス第2版(阿部達生篇)
    日本醫事新報社(東京) 1991
Lectures and oral presentations  (7):
  • DANメチル化プロファイルを用いたラブドイド腫瘍患者の同時多発病変より樹立した新規2細胞株の解析
    (日本癌学会総会記事 2020)
  • 転写因子RUNX1/AML1の新規候補標的遺伝子群の探索
    (日本生化学会大会プログラム・講演要旨集 2019)
  • RUNX1の新規転写標的候補
    (日本生化学会大会プログラム・講演要旨集 2018)
  • 造血関連転写因子RUNX1(AML1)の転写標的候補遺伝子(Analysis of a novel candidate target gene of the hematopoietic transcription factor RUNX1(AML1))
    (臨床血液 2018)
  • SNF5と転写因子の相互作用によるSWI/SNF複合体のプロモーター領域へのリクルート機構
    (生命科学系学会合同年次大会 2017)
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Professional career (1):
  • M. D. , Ph. D. (Kyoto Prefectural University of Medicine)
Work history (2):
  • 1984/04 - 1985/03 国立鯖江病院 内科 医師
  • 1982/05 - 1984/03 京都府立医科大学附属病院 第三内科 研修医
Committee career (1):
  • 日本血液学会 代議員
Awards (4):
  • 2004 - 公益信託 日本白血病研究基金 清水賞
  • 2004 - Japan Leukaemia Research Fund Shimizu Award
  • 1997 - 京都府立医科大学学友会青蓮賞
  • 1997 - Shouren-Shou Award (Kyoto Prefectural University of Medicine Alumni Award)
Association Membership(s) (7):
米国血液学会 ,  米国癌学会 ,  日本生化学会 ,  日本分子生物学会 ,  日本血液学会 ,  日本内科学会 ,  日本癌学会
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