Rchr

J-GLOBAL ID：200901022629721551 Update date: Aug. 04, 2024

Okuda Tsukasa

オクダツカサ | Okuda Tsukasa

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.kpu-m.ac.jp

Research field (4)： Hematology and oncology , Pathobiochemistry , Medical biochemistry , Molecular biology

Research keywords (14)： RUNX1 , AML1 , tumor suppressor gene , oncogene , transcription factor , hematopoietic stem cell , leukemia , chromosome translocation , 生化学 , 血液学/腫瘍学 , 分子生物学 , biochemistry , hematology/oncology , molecular biology

Research theme for competitive and other funds (52)：

2022 - 2025 Establishment of new intervention methods for hematopoietic transcriptional control for clinical application.
2022 - 2025 Functional analysis of transcription factors and novel SWI/SNF complexes in the tumorigenesis of rhabdoid tumors.
2019 - 2022 Search for novel intervention methods for hematopoietic transcription control and research for its clinical application
2019 - 2022 Elucidation of cell differentiation by hematopoietic transcription factor RUNX1 and translation to a novel molecular target strategy
2019 - 2022 Elucidation of the molecular mechanisms of malignant rhabdoid tumors mediated by dysregulation of super-enhancer function.

2017 - 2020 Analysis of hematopoietic regulation mechanisms by a novel repressor for RUNX1

2016 - 2019 Nalysis of novel tumor suppressor gene RUNX3 of gastric cancer and clinical application for the diagnosis and prevention of gastric cancer

2016 - 2019 The clarification of a tumorigenesis of malignant rhabdoid tumor through a understanding of control mechanism of RUNX1 by hSNF5

2016 - 2019 Regulation mechanisms of hematopoietic transcription factor RUNX1 through the transcription network analyses

2015 - 2018 RUNX1 as a molecular target for a novel hematopoietic reguation

2013 - 2016 Analysis of novel gastric tumor suppressor RUNX3 for the clinical application of gastric cancer treatment

2014 - 2015 Runx1による造血幹細胞産生メカニズムの解明

2012 - 2015 Regulatory mechanisms of the leukemia-associated transcription factor, RUNX1/AML1, through the post-translational modifications.

2011 - 2013 Does Runx1 produce hematopoietic stem cell from hemogenic endothelium via Endothelial to Mesenchymal Transition?

2010 - 2012 Analysis of novel tumor suppressor gene RUNX3 of gastric cancer and clinical application for the diagnosis and prevention of gastric cancer

2009 - 2011 Transcriptional Dysregulation in Abnormal Hematopoiesis and Leukemia

2007 - 2008 Molecular analysis of novel tumor suppressor RUNX3 in gastric cancers and its clinical application

2006 - 2007 胃癌新規癌抑制遺伝子RUNX3の異常を伴う胃癌前駆細胞の同定と遺伝子診断への応用

2006 - 2007 Leukemogenic Mechanism by genomic mutations of hematopoietic-speci is transcription factor, AML1/RUNX1

2005 - 2006 Analysis of novel tumor suppressor gene RUNX3 in gastric cancer

2003 - 2006 Making a transgenic mouse with α 2A adrenoceptor fused with GFP

2004 - 2005 胃癌新規癌抑制遺伝子RUNX3の異常を伴う胃癌前駆細胞の同定と遺伝子診断への応用

2004 - 2005 Molecular analysis for hematopoietic regulation by transcription factor, AML1/Runxl.

2003 - 2004 Application of RUNX3 in the diagnosis and treatment of gastric cancer

2003 - 2003 AML1/RUNX1遺伝子の微細変異による造血器腫瘍発症メカニズムの検討

2002 - 2003 IDENTIFICATION OF CHROMOSOMAL REARRANGEMENTS SPECIFIC TO MYELODYSPLASTIC SYNDROME USING MULTICOLOR SPECTRAL KARYOTYPING

2002 - 2003 Molecular dissection of the leukemia-associated transcription factor, AML1/RUNX1,in hematopoietic regulation

2002 - 2002 新しい胃癌の癌抑制遺伝子RUNX3の解析と遺伝子診断への応用

2002 - 2002 白血病・骨髄異形成症候群発症におけるAML1遺伝子変異の生物学的意義

2002 - 多因子病のマウスモデル作成

2002 - Generation of mouse models for common diseases

2001 - 2001 白血病発症におけるAML1遺伝子変異の生物学的意義に関する研究

2000 - 2001 SUBCLASSFICIATION OF MULTIPLE MYELOMA BASED ON THE PARTNER GENES OF TUMOR-SPECIFIC IMMUNOGLOBULIN HEAVY CHAIN GENE TRANSLOCATION BY USING DOUBLE-COLOR FLUORESCENCE IN SITU HYBRIDIZATION

2000 - 2001 Molecular basis for leukemic transformation caused by chimeric protein involving the transcription factor AML1 (PEBP2aB).

2000 - 2001 Analysis of novel tumor suppressor gene AML2 in gastric cancer

2000 - 2001 Functional analysis of the Bim/DLC complex in apoptosis regulation of hematopoietic progenitors

2000 - 2000 AML1(PEBP2αB)遺伝子の融合型変異たよる白血病発症メカニズムの研究

2000 - 2000 転写因子AML1/PEBP2αBによる造血初期発生制御機構

1999 - 1999 Biologic characterization of leukemia-associated transcription factor AML1 (PEBP2αB) in hematopoiesis

1998 - 1999 INTERPHASE DETECTION OF GENE REARRANGEMENTS SPECIFIC TO NON-HODGKIN'S LYMPHOMA USING DOUBLE-COLOR FISH

1998 - 1999 Molecular mechanism of hematopoietic regulation by leukemia-related transcription factor AML1(PEBP2αB)

1998 - 1999 FLT3 gene

1998 - 1998 AML1/PEBP2αBプロトオンコジーンによる造血制御の分子メカニズム

1997 - 1998 Analysis of crosstalks between hematopoietic signals and their molecular mechanisms

1997 - 1997 AML1/PEBP2αBプロトオンコジーンによる造血制御の分子メカニズム

1985 - マウス発生工学的手法による発癌メカニズムの解析

1985 - 白血病発症に関与するシグナル伝達異常の探索とその分子機構についての研究

1985 - 造血発生制御の分子機構に関する研究

1985 - Study on Molecular Mechanism of Oncogenesis through Mouse Developmental Genetics

1985 - Study on Mutations of Mitogenic Signal Transduction Pathway which leads to Leukemic Transformation

1985 - Study on Molecular Mechanism of Hematopoietic Regulation

分子生物学、生化学、腫瘍遺伝学

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Papers (70)：

Yasumichi Kuwahara, Tomoko Iehara, Akifumi Matsumoto, Tsukasa Okuda. Recent insights into the SWI/SNF complex and the molecular mechanism of hSNF5 deficiency in rhabdoid tumors. Cancer medicine. 2023
Haruka Shinohara, Rie Sawado, Makoto Nakagawa, Ayuna Hattori, Kazutsune Yamagata, Kimiharu Tauchi, Jumpei Ito, Yasumichi Kuwahara, Tsukasa Okuda, Chitose Ogawa, et al. Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors. Molecular Therapy - Oncolytics. 2022. 27. 14-25
Akifumi Matsumoto, Tatsushi Yoshida, Takahiro Shima, Kenta Yamasaki, Kenjiro Tadagaki, Noriko Kondo, Yasumichi Kuwahara, Dong-Er Zhang, Tsukasa Okuda. C11orf21, a novel RUNX1 target gene, is down-regulated by RUNX1-ETO. BBA Advances. 2022. 2. 100047-100047
Tatsushi Yoshida, Kenta Yamasaki, Kenjiro Tadagaki, Yasumichi Kuwahara, Akifumi Matsumoto, Adèm Sofovic, Noriko Kondo, Toshiyuki Sakai, Tsukasa Okuda. Tumor necrosis factor-related apoptosis-inducing ligand is a novel transcriptional target of runt-related transcription factor 1. International Journal of Oncology. 2021. 60. 1
YASUMICHI KUWAHARA, TOMOKO IEHARA, EISUKE ICHISE, YOSHIKI KATSUMI, KAZUTAKA OUCHI, KUNIHIKO TSUCHIYA, MITSURU MIYACHI, EIICHI KONISHI, HIROYASU SASAJIMA, SATOAKI NAKAMURA, et al. Novel Two MRT Cell Lines Established from Multiple Sites of a Synchronous MRT Patient. Anticancer Research. 2020. 40. 11. 6159-6170

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MISC (56)：

桑原康通, 忠垣憲次郎, 奥田司. 【がん研究・診療を巡る最新トピックス】エンハンサー制御と腫瘍発生. 京都府立医科大学雑誌. 2019. 128. 2. 69-78
山崎健太, 忠垣憲次郎, 近藤則子, 桑原康通, 吉田達士, 奥田司. 造血関連転写因子RUNX1による制御遺伝子の探索. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
忠垣憲次郎, 山崎健太, 近藤則子, 桑原康通, 吉田達士, 奥田司. 転写因子RUNX1/AML1の新規候補標的遺伝子群の探索. 日本生化学会大会(Web). 2019. 92nd
忠垣憲次郎, 山崎健太, 近藤則子, 桑原康通, 吉田達士, 奥田司. 造血関連転写因子RUNX1(AML1)の新規転写標的候補遺伝子の探索. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
桑原康通, 細井創, 奥田司. 【腫瘍の生化学と分子生物学:最新の理解】クロマチンリモデリングの異常と腫瘍発生. 京都府立医科大学雑誌. 2015. 124. 12. 825-837

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Books (3)：

Role of AML1 in normal and leukemic hematopoiesis.
Kyushu University Press(Fukuoka, Japan)・“Molecular Target for Hematological Malignancies and Cancer"(ed. by Niho, Y. ) 2000
ノックアウトマウス・データブック(野口茂、平井久丸編)
中山書店 1997
造血器腫瘍アトラス第2版(阿部達生篇)
日本醫事新報社(東京) 1991

Lectures and oral presentations (7)：

DANメチル化プロファイルを用いたラブドイド腫瘍患者の同時多発病変より樹立した新規2細胞株の解析
(日本癌学会総会記事 2020)
転写因子RUNX1/AML1の新規候補標的遺伝子群の探索
(日本生化学会大会プログラム・講演要旨集 2019)
RUNX1の新規転写標的候補
(日本生化学会大会プログラム・講演要旨集 2018)
造血関連転写因子RUNX1(AML1)の転写標的候補遺伝子(Analysis of a novel candidate target gene of the hematopoietic transcription factor RUNX1(AML1))
(臨床血液 2018)
SNF5と転写因子の相互作用によるSWI/SNF複合体のプロモーター領域へのリクルート機構
(生命科学系学会合同年次大会 2017)

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Professional career (1)：

M. D. , Ph. D. (Kyoto Prefectural University of Medicine)

Work history (2)：

1984/04 - 1985/03 国立鯖江病院内科医師
1982/05 - 1984/03 京都府立医科大学附属病院第三内科研修医

Committee career (1)：

日本血液学会代議員

Awards (4)：

2004 - 公益信託日本白血病研究基金清水賞
2004 - Japan Leukaemia Research Fund Shimizu Award
1997 - 京都府立医科大学学友会青蓮賞
1997 - Shouren-Shou Award (Kyoto Prefectural University of Medicine Alumni Award)

Association Membership(s) (7)：

米国血液学会 , 米国癌学会 , 日本生化学会 , 日本分子生物学会 , 日本血液学会 , 日本内科学会 , 日本癌学会

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