Masatoshi Tomi

トミマサトシ | Masatoshi Tomi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.pha.keio.ac.jp/faculty/pdf/tomi_reserch.pdf

Research field (1)： Clinical pharmacy

Research theme for competitive and other funds (15)：

2024 - 2027 Ex vivo-in silicoハイブリッドによるヒト胎児薬物移行の新解析プラットフォーム構築
2021 - 2024 輸送分子種差と遊離形濃度に基づくヒト胎児への経胎盤薬物曝露量予測モデルの構築
2020 - 2022 Regulation of pharmacokinetics during pregnancy by placental exosomes
2018 - 2021 Significance of a balanced tryptophan diet for supporting fetal growth
2015 - 2018 Functional expression of sensing foctors against maternal osmotic stress in the placenta

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Papers (99)：

Fukazawa N, Nishimura T, Orii K, Noguchi S, Tomi M. Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1. Pharmaceutical Research. 2024. 41. 5. 849-861
Tomohiro Nishimura, Hikari Araki, Kei Higuchi, Saki Noguchi, Kei Saito, Kanako Hara, Haruya Yagishita, Risa Akashi, Sakiko Obata, Masatoshi Tomi. Involvement of GAT2/Slc6a13 in hypotaurine uptake at fetal-facing plasma membrane of syncytiotrophoblasts at mid-to-late gestation in rats and mice. Placenta. 2024. 147. 59-67
Nishimura T, Ishii M, Tanaka H, Noguchi S, Ikeda T, Tomi M. Breast Cancer Resistance Protein Limits Fetal Transfer of Tadalafil in Mice. Journal of Pharmaceutical Sciences. 2024. 113. 2. 486-492
Akashi T, Noguchi S, Takahashi Y, Nishimura T, Tomi M. L-Type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids. Journal of pharmaceutical sciences. 2023. 112. 4. 1137-1144
Arimi Fujita, Saki Noguchi, Rika Hamada, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi. Quantitative Comparison of Breast Cancer Resistance Protein (BCRP/ABCG2) Expression and Function Between Maternal Blood-Brain Barrier and Placental Barrier in Mice at Different Gestational Ages. Frontiers in Drug Delivery. 2022. 2. 932576

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MISC (37)：

黒沢健, 登美斉俊, 千葉康司. 【胎盤の母児支援機構とその評価】ファーマコメトリクスを応用したヒト胎児薬物曝露量予測. 細胞. 2024. 56. 3. 158-162
西村友宏, 石井まり, 野口幸希, 田中博明, 池田智明, 登美斉俊. タダラフィルのマウス胎仔移行におけるBCRPの関与. 日本薬学会年会要旨集. 2022. 142年会. 26C-pm04
登美斉俊. 【妊娠・授乳中の薬剤の安全性について科学する】薬物の胎児移行性評価と薬物療法. Precision Medicine. 2021. 4. 10. 918-921
Ishikawa Satoko, Inoue Kae, Tomi Masatoshi. Faculty challenges during the SARS-CoV-2 pandemic and the results of student questionnaires for the implementation of online and face-to-face classes. Japanese Journal of Pharmaceutical Education. 2021. 5. 0. n/a
登美斉俊. 【周産期の薬】産科編総論薬物の経胎盤透過. 周産期医学. 2020. 50. 増刊. 46-48

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Books (22)：

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Lectures and oral presentations (365)：

Prediction of Fetal Drug Exposure by integrating in vitro, in vivo, ex vivo, and in silico approaches
(Asian Federation for Pharmaceutical Sciences 2023)
Enhanced invasion of extravascular trophoblast cells by human vascular endothelial cells and its effect on gene expression
(Asian Federation for Pharmaceutical Sciences 2023)
Fetal transfer of tadalafil, a PDE5 inhibitor, is limited by BCRP at murine placental barrier
(Asian Federation for Pharmaceutical Sciences 2023)
Transport mechanism of propionic acid in human choriocarcinoma JEG-3 cells
(Asian Federation for Pharmaceutical Sciences 2023)
マウス胎盤におけるMFSD2Aの発現とlysophosphatidylcholine結合型docosahexaenoic acid透過に与える影響
(第44回生体膜と薬物の相互作用シンポジウム)

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Education (5)：

2001 - Tohoku University Graduate School, Division of Pharmaceutical Sciences 生命薬学専攻
2001 - 2001 Tohoku University Graduate School, Division of Pharmaceutical Sciences 生命薬学専攻
2000 - Tohoku University Graduate School, Division of Pharmaceutical Sciences 分子生命薬学専攻
2000 - 2000 Tohoku University Graduate School, Division of Pharmaceutical Sciences 分子生命薬学専攻
1998 - 1998 Tohoku University Faculty of Pharmaceutical Science 薬学科

Professional career (1)：

Work history (6)：

2016/04 - 現在 Professor, Faculty of Pharmacy, Keio University
2011/04 - 2016/03 Associate Professor, Faculty of Pharmacy, Keio University
2009/01 - 2011/03 Senior Assistant Professor, Faculty of Pharmacy, Keio University
2006/04 - 2008/12 Postdoctoral Fellow, David Geffen School of Medicine, University of California, Los Angeles (UCLA)
2005/10 - 2006/03 Assistant Professor, Faculty of Pharmaceutical Sciences, University of Toyama

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Awards (7)：

2019 - Journal of Pharmaceutical Sciences 2019 Top Reviewer
2018 - Journal of Pharmaceutical Sciences 2018 Top Reviewer
2017 - Journal of Pharmaceutical Sciences 2017 Top Reviewer
2015 - The Academy of Pharmaceutical Science and Technology, Japan 日本薬剤学会奨励賞関門トランスポーターによる薬物組織分布制御機構の研究
2015 - 慶應義塾大学薬学部学部長賞

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