Akimoto Takayuki

アキモトタカユキ | Akimoto Takayuki

Affiliation and department：
Homepage URL (1)： https://sem-muscle.w.waseda.jp/index.html

Research field (3)： Nutrition and health science , Physiology , Sports science

Research keywords (4)： adaptation , mesenchymal tissue , メカニカルストレス , Mechanical stress

Research theme for competitive and other funds (24)：

2022 - 2027 マルチオミックス解析を用いた新規老化関連バイオマーカーの開発
2021 - 2025 Regulation of life span by the exercise-responsible miRNAs
2020 - 2024 運動によるインスリン抵抗性改善の分子基盤
2019 - 2022 マイクロRNA欠損による早期老化のメカニズムの解明
2017 - 2019 Development of fluorescent probe for glucose uptake into skeletal muscle

2016 - 2019 Role of microRNAs in exercise-induced angiogenesis

2015 - 2019 Development of novel biomarkers on exercise, stress and aging and their functional analyses

2014 - 2017 The mechanism underlying sleep disorder-induced decrease in athletic performance and its improvement

2014 - 2016 development of in vivo imaging system for skeletal muscle biology

2013 - 2016 The role of microRNAs in mechanical stress-induced muscle adaptation

2011 - 2015 Development of novel biomarkers on exercise, stress and aging

2010 - 2014 Monitoring stress protein in saliva to prevent impairment of physical condition in athletes and elderly individuals

2011 - 2013 Effect of mechanical stress on stemness of embryonic stem cells

2009 - 2011 Local muscular steroidogenesis and exercise for anti-aging

2009 - 2010 Functional analysis of mechanical stress-induced microRNAs

2007 - 2009 The effects of exercise on immune senescence in elderly

2006 - 2008 Regulation of mesenchymal cell differentiation by mechanical stress via PGC-1a

2006 - 2007 感染症に対する抵抗力を反映する新規指標の開発

2006 - 2007 Development of the personalized health promotion program for the prevention of life-style related disease : Contribution of Cardiorespiratory Fitness and Obesity Genes to the Risk Factors of Metabolic Syndrome

2007 - ダイナミックな環境における細胞内シグナルの可視化

2004 - 2005 An analysis of the non-contact anterior cruciate ligament injury

2004 - 2004 培養細胞系を用いた物理的刺激によるPGC-1遺伝子活性化メカニズムの解析

2001 - 2003 Development of a SIgA measurement kit for monitoring of risk of URTI

メカニカルストレスによる細胞分化制御

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Papers (79)：

Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa, et al. The Rubicon-WIPI axis regulates exosome biogenesis during ageing. Nature cell biology. 2024. 26. 9. 1558-1570
Yuichi Akama, Eun Jeong Park, Naoko Satoh-Takayama, Atsushi Ito, Eiji Kawamoto, Arong Gaowa, Eri Matsuo, Satoshi Oikawa, Masafumi Saito, Shigeaki Inoue, et al. Roles of programmed death-1 and muscle innate lymphoid cell-derived interleukin 13 in sepsis-induced intensive care unit-acquired weakness. Journal of cachexia, sarcopenia and muscle. 2024
Shigeki Ishibashi, Naosuke Kamei, Yuji Tsuchikawa, Toshio Nakamae, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi. Myelin-Specific microRNA-23a/b Cluster Deletion Inhibits Myelination in the Central Nervous System during Postnatal Growth and Aging. Genes. 2024. 15. 4
Satoshi Oikawa, Shuaibang Yuan, Yoshio Kato, Takayuki Akimoto. Skeletal muscle-enriched miRNAs are highly unstable in vivo and may be regulated in a Dicer-independent manner. The FEBS journal. 2023. 290. 24. 5692-5703
Jaehoon Shin, Shigeru Miyaki, Hiroshi Asahara, Takayuki Akimoto. MicroRNA-140 is not involved in sepsis-induced muscle atrophy. American journal of physiology. Cell physiology. 2023. 325. 2. C509-C518

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MISC (257)：

及川哲志, 秋本崇之. 生体骨格筋におけるマイクロRNAの代謝動態. 日本筋学会学術集会プログラム・抄録集. 2021. 7th
佐野将之, 森下加奈, 及川哲志, 秋本崇之, 須丸公雄, 加藤義雄. Development of an miRNA detection system with post-transcriptional feedback control. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
加藤達也, 及川哲志, 李ミンジョン, 秋本崇之. miR-23-27-24クラスターマイクロRNAの欠損が骨格筋の発生・可塑性に及ぼす影響. 日本筋学会学術集会プログラム・抄録集. 2020. 6th
李ミンジョン, 和田正吾, 及川哲志, 鈴木克彦, 牛田多加志, 秋本崇之. miR-23-27-24クラスターmiRNAの筋特異的な欠損は持久性運動による骨格筋の適応に影響しない. 日本筋学会学術集会プログラム・抄録集. 2019. 5th
及川哲志, 李ミンジョン, 本橋紀夫, 前田清司, 秋本崇之. 生体マウスにおけるDicerの欠損は持久性運動による骨格筋適応に影響しない. 日本筋学会学術集会プログラム・抄録集. 2019. 5th

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Patents (2)：

細胞の糖取り込みを可視化するためのキメラタンパク質
抗筋萎縮剤

Professional career (1)：

Ph.D. (Medical Sciences) (University of Tsukuba)

Work history (6)：

2016/04 - 現在 Waseda University Faculty of Sport Sciences
2007/09 - 2016/03 The University of Tokyo Graduate School of Medicine Assistant Professor
2010/03 - 2011/01 University of Padova Visiting Professor
2005/09 - 2007/08 Waseda University
2003/08 - 2006/01 Duke University Medical Center Research Associate

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Committee career (10)：

2022 - 現在 Japan Anti-doping Agency Committee for Health and Medical Sciences
2022 - 現在 International Journal of Sports Medicine Editorial board member
2019 - 現在 Scientific Reports Editorial Board member
2019 - 現在日本体力医学会渉外委員会委員
2019 - 現在日本スポーツ振興センターハイパフォーマンススポーツセンターアドバイザー

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Awards (6)：

2016 - Waseda Research Award
2006 - Young Investigator Award, International Research Group on Biochemistry of Exercise
2006 - 早稲田大学先端科学・健康医療融合研究機構優秀業績賞
2004 - 日本体力医学会若手奨励賞
2004 - Research Recognition Award, The American Physiological Society

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Association Membership(s) (7)：

American Physiological Society , Japan Muscle Society , 日本臨床スポーツ医学会 , 日本体力医学会 , European College of Sports Science , International Society of Exercise & Immunology , American Society for Cell Biology

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