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J-GLOBAL ID：200901022938389790   Update date: Apr. 19, 2024

Nishinakamura Ryuichi

ニシナカムラ リユウイチ | Nishinakamura Ryuichi
Affiliation and department：
Kumamoto University Institute of Molecular Embryology and Genetics, ,Institute of Molecular Embryology and Genetics,Kumamoto University

About Kumamoto University Institute of Molecular Embryology and Genetics, ,Institute of Molecular Embryology and Genetics,Kumamoto University


Job title： Professor
Research field  (1)： Developmental biology
Research theme for competitive and other funds  (39)：
  • 2021 - 2026 Reconstitution of the higher-order structure of the human kidney based on stromal progenitor induction
  • 2017 - 2022 Kidney reconstitution and and disease modeling based on nephron induction methods in vitro
  • 2018 - 2020 Selective induction of functional epithelia from human iPS cell-derived nephron progenitors
  • 2016 - 2019 Propagation of human iPS-derived nephron progenitors in vitro
  • 2017 - 2018 Analysis of human kidney deveopment based on the nephron induction method in vitro
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Papers (149)：
  • Matthew P Pappas, Hiroko Kawakami, Dylan Corcoran, Katherine Q Chen, Earl Parker Scott, Julia Wong, Micah D Gearhart, Ryuichi Nishinakamura, Yasushi Nakagawa, Yasuhiko Kawakami. Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development (Cambridge, England). 2024. 151. 5
  • Katherine Q Chen, Hiroko Kawakami, Aaron Anderson, Dylan Corcoran, Aditi Soni, Ryuichi Nishinakamura, Yasuhiko Kawakami. Sall genes regulate hindlimb initiation in mouse embryos. Genetics. 2024
  • Ryuichi Nishinakamura. Advances and challenges toward developing kidney organoids for clinical applications. Cell stem cell. 2023. 30. 8. 1017-1027
  • Hiroko Kawakami, Katherine Q Chen, Ruizhi Zhang, Matthew P Pappas, Abigail Bailey, Julie A Reisz, Dylan Corcoran, Ryuichi Nishinakamura, Angelo D'Alessandro, Yasuhiko Kawakami. Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes. Developmental biology. 2023. 501. 28-38
  • Shunsuke Tanigawa, Etsuko Tanaka, Koichiro Miike, Tomoko Ohmori, Daisuke Inoue, Chen-Leng Cai, Atsuhiro Taguchi, Akio Kobayashi, Ryuichi Nishinakamura. Author Correction: Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma. Nature communications. 2023. 14. 1. 1874-1874
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MISC (116)：
  • The present and future of kidney organoids. 2024. 42. 5. 721-727
  • 古家圭士郎, 西中村隆一. 腎臓の再生医療に向けた進歩と展望. 日本腎臓学会誌. 2023. 65. 8. 936-941
  • 野口 剛, 軸屋 良介, Wilan Krisna, 大竹 慎二, 加藤 生真, 舟橋 慎太郎, 西澤 秀和, 古屋 充子, 古目谷 暢, 三留 拓, et al. iPS細胞から作製したALK関連腎癌オルガノイドの機能解析. 腎癌研究会会報. 2023. 53. 28-28
  • 田中悦子, 谷川俊祐, 西中村隆一. 間質前駆細胞誘導法の開発に基づく完全に多能性幹細胞由来腎臓高次構造の構築. 発達腎研究会誌. 2023. 30. 1. 27-32
  • 西中村隆一. 試験管内で腎臓を作る. きんむ医. 2023. 204. 21-24
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Books (5)：
  • 小児泌尿器科学
    診断と治療社 2021
  • Acute kidney injury and regenerative medicine
    Springer 2020
  • 内科学書
    中山書店 2019
  • Organ regeneration based on developmental biology
    Springer 2017
  • Kidney development, disease, repair, and regeneration
    Academic Press 2015
Lectures and oral presentations  (165)：
  • Integrated Reconstruction of the Solid Organ (Kidney)
    (2024)
  • Kidney organoids for modeling development and disease
    (2023)
  • 試験管の中で腎臓を作る
    (沖縄腎臓病協議会 2023)
  • Reconstructing the kidney from pluripotent stem cells
    (Clinical application of stem cells in kidney transplantation and nephrology 2023)
  • Kidney Organoids with Higher Order Structure
    (The 15th International Workshop on Developmental Nephrology 2023)
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Works (11)：
  • ES細胞からの腎臓細胞誘導法の開発
    2007 - 2008
  • 新規遺伝子による腎臓発生制御機構
    2007 - 2008
  • 腎臓の細胞運命転換技術の開発
    2006 - 2008
  • 新規遺伝子群による生殖細胞発生の制御機構
    2006 - 2008
  • ノックアウトマウスを用いた腎臓発生期遺伝子の成体腎障害時における機能解析
    2005 - 2007
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Education (4)：
  • - 1996 The University of Tokyo
  • - 1996 The University of Tokyo Graduate School, Division of Medical Sciences
  • - 1987 The University of Tokyo Faculty of Medicine School of Medicine
  • - 1987 The University of Tokyo Faculty of Medicine
Professional career (1)：
  • Doctor of Medicine (The University of Tokyo)
Work history (6)：
  • 2009 - 現在 Kumamoto University Institute of Molecular Embryology and Genetics Professor
  • 2016/04 - 2020/03 Institute of Molecular Embryology and Genetics, Kumamoto University Director
  • 2009 - Professor, ,Institute of Molecular Embryology and Genetics,Kumamoto University
  • 2000 - Visiting Associate Professor, The Insitute of Medical Science,The University of Tokyo
  • 1996 - The University of Tokyo The Institute of Medical Science
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Association Membership(s) (5)：
日本内科学会 ,  アメリカ腎臓学会 ,  日本分子生物学会 ,  日本腎臓学会 ,  American Society of Nephrology
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