2019 - 2023 Development of novel embryonic stem cell-based cartilage for pediatric airway stenosis
2019 - 2022 Controlling the lifespan of human somatic stem cells to solve regenerative medicine bottlenecks in aesthetic plastic surgery
2019 - 2022 Therapy of non-alcoholic steatohepatitis by adipose tissue-derived mesenchymal stem cells and safety
2017 - 2020 Development of in vivo recruitment of macrophages and stem cells aiming at regenerative therapy of natural healing potential enhancement
2015 - 2020 Applied research for new preventive strategy for congenital retinal degenerative diseases using differentiation / regeneration technology
2015 - 2020 Critical epigenome identification of human iPS / ES cells based on machine learning analysis of teratoma pathology
2016 - 2019 Development of fetal treatment strategy using human ES cell preparation for liver failure model
2016 - 2019 Hedgehog signaling in human diseases
2016 - 2019 Development of immune therapy for non-alcoholic fatty liver disease with iNKT cells
2015 - 2019 Fetal therapy model using amniotic fluid-derived iPS cells
2015 - 2019 Analysis of biological characteristics and pathogenesis of human and mouse lymphangioma animal models
2015 - 2018 Search for biodegradable scaffolding materials of bones and ligaments in growth and medicine and creation of fusion proteins
2015 - 2018 Establishment of treatment strategy by stem cell transplantation for I-cell disease model mouse
2015 - 2018 Realization of regenerative medical system using human ES cells for congenital metabolic disorders
2015 - 2018 Creation of human novel totipotent stem cells (Superstem cell) and construction of pathological characteristics analysis database
2015 - 2018 Life control of human somatic stem cells based on "pathology of human papilloma virus"
2014 - 2017 Exploit of an alternative stem cell transplantation in utero based on feto-maternal tolerance using allogeneic donor cells immunologically matched to the mother.
2014 - 2017 Construction of cell evaluation system utilizing online distributed machine learning
2014 - 2017 Optimization of regeneration technique for bone and cartilage derived from iPS cells
2013 - 2017 Cell treatment model for implantation failure using mesenchymal stem cells
2013 - 2017 Generation of high-quality embryonic stem cells by new reprogramming technique and a basic research for regenerative medicine
2013 - 2016 Fate determination and function acquisition during induction/regeneration of photoreceptors from human somatic cells
2013 - 2016 Investigation of the mechanisms and development of new therapies for lung hypoplasia
2013 - 2016 Identification of carbohydrate structures defining ageing of human stem cells for cell therapy products
2013 - 2016 Identification of Cardiomyogenic Factor and Improved Efficiency of Cardiomyogenesis in Human Mesenchymal Stem Cells(MSCs)- Participation of new immune cells -
2013 - 2016 molecular mechanisms of genomic rejuvenation during preimplantation development
2013 - 2016 Attempt of generation of disease-specific iPS cells from dog/cat.
2013 - 2016 Development of tissue engineering technology to modify biological functions for stem cell regeneration medicine
2012 - 2016 Modelling childhood neurotransmitter diseases using iPSCs
2011 - 2016 Analysis and control of cell function based on novel glycomics using saccharide primer method
2013 - 2015 小児薬剤に対する新型iPS細胞由来肝細胞による先駆的解析システム戦略の創成
2012 - 2015 Generation of human iPS cells derived from ocular tissues and their use for functional analysis, novel diagnostic technique and medical treatment
2012 - 2015 Development of A Cell Based Therapy for Animal Models for Lysosomal Storage Disorder
2012 - 2015 Development of detection of EBV infection and monitoring of immunosuppression by molecular analysis after pediatric liver trasplantation
2012 - 2015 Implantation of erythropoietin-cultured bone marrow stromal cell in patients with intractable peripheral artery disease
2011 - 2015 Establishment of the animal model of lymphangioma using human lymphangioma derived lymphatic endothelial cell
2010 - 2015 Development of new treatment for eye diseases by use of combination with gene therapy, cellular therapy and reproducing medicine.
2010 - 2015 Establishment a therapeutic strategy to children with heart failure
2010 - 2012 Cellular and Molecular Biological Study on Pathogenesis and Treatment of Myopia
2010 - 2012 Regenerative medicine for heart failure in large animal models
2010 - 2012 Gene cascades for starting development and generating totipotency
2008 - 2012 Development of Technology to Manipulate the Biological Functions of Stem Cells for Cell Therapy of Next Generation
2010 - 2011 Establishment of human iPS cells originated from retinal tissues
2009 - 2011 難治性疾患克服のための難病研究資源バンク開発研究
2009 - 2011 ヒト胚性幹(ES)細胞を生かすことができるヒトフィーダー単離システムの創成
2009 - 2011 Establishment of human cells as feeder cells of human embryonic stem cells
2009 - 2011 Custom-shaping system for bone regeneration by seeding marrow stromal cells
2009 - 2011 Experimental Study on Nicotine-Nicotine acts directly on growth plate chondrocytes to delay enchondral ossification through the alpha7 homopentameric neuronal nicotinic acetylcholine receptor-
2009 - 2011 Analysis of Epstein-Barr virus infection following pediatric liver transplantation by molecular EBV monitoring
2008 - 2011 ヒト心筋形成物質(因子)の同定-ヒト心筋の再生誘導-
2010 - 2010 ステロイド依存性感音難聴の新しい診断方法および診断基準に関する検討
2008 - 2010 「幹細胞工学→再生医療」におけるナノ・トレースシステムの創成
2008 - 2010 内耳性難聴に対する細胞移植システムの構築
2008 - 2010 Bio-function of glycolipids in uterine endometrial adencarcinoma and cervical carcinoma, and uterine endometrium
2007 - 2009 Validation system for aging in human egg cells based on carbohydrate structures and in vitro maturation
2006 - 2009 Gene therapy, cellular transplantation and reproducing medicine for corneal diseases
2006 - 2008 キメラタンパクを用いた骨再生用インテリジェント足場材料の開発
2006 - 2008 「子宮内造血幹細胞移植」の創成と評価システムの確立
2006 - 2008 In utero stem cell transplantation for fetal therapy
2005 - 2008 Basic study about cell-based therapy by cell life span control using human papillomavirus
2007 - 2007 先天性代謝性疾患の眼病変に対する眼組織幹細胞を用いた治療戦略
2006 - 2007 Gene expression in the mouse growth plate
2004 - 2007 The establishment of methods for cardiomyocyte differentiation with human umbilical cord blood-derived mesenchymal stem cells aimed the application into the treatment of pediatric heart failures
2003 - 2007 Development of functional cell scaffolds and bioreactors for regenerative medicine based on stem cells
- 1990 Keio University Graduate School, Division of Medicine
- 1985 Keio University School of Medicine
- 1985 Keio University Faculty of Medicine
Professional career (1)：
M.D., Ph. D (Keio University)
Work history (6)：
1999 - 2002 慶應義塾大学 助教授(医学部病理学教室)
2002 - - 国立成育医療センター生殖医療研究部 部長
1995 - 1999 慶應義塾大学 専任講師(医学部病理学教室)
1992 - 1995 米国ラ・ホヤ癌研究所(現バーナム研究所)研究員
1991 - 1992 米国カルフォルニア大学サンディエゴ校内科学教室 研究員
1989 - 1991 Keio University School of Medicine, Department of Pathology
Show all
Committee career (1)：
日本病理学会 評議医員
Awards (3)：
1997 - 北里賞,1997,慶應義塾医学部(三四会)
1993/04 - Trainee Investigator Award for excellence in Scientific Research, American Society for Clinical Investigation, Association of American Physicians.
1993/04 - Henry Christian Memorial Award, American Federeation for Clinical Research Foundation
