Rchr
J-GLOBAL ID:200901023842581549
Update date: Jan. 30, 2024
Sasaguri Toshiyuki
ササグリ トシユキ | Sasaguri Toshiyuki
Affiliation and department:
Job title:
Professor
Other affiliations (3):
Homepage URL (1):
http://www.med.kyushu-u.ac.jp/clipharm/
Research field (3):
Cardiology
, Internal medicine - General
, Pharmacology
Research keywords (21):
differentiation-inducing factor
, 臨床薬理
, 腫瘍薬理
, 一酸化窒素
, プロスタグランジン
, 血管細胞
, 心不全
, 狭心症
, 動脈硬化
, 高血圧
, 心血管薬理
, clinical pharmacology
, cancer chemotherapy
, nitric oxide
, prostaglandins
, vascular cells
, heart failure
, angina
, atherosclerosis
, hypertension
, cardiovascular pharmacology
Research theme for competitive and other funds (14):
- 2017 - 2020 Identification of the tareget molecule for GSK-3 activator DIF towards clinical usage
- 2011 - 2012 Identification of an inhibitor of mPGES-1 expression and its target molecule
- 2008 - 2010 Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitrates
- 2004 - 2005 The clinical study on relationship between periodontal disease and atherosclerosis
- 2002 - 2004 Studies on the signal transduction of difrentiation inducing factor and an application for the development of anti-cancer drug for early G_1 phase.
- 2002 - 2002 微生物由来細胞分化誘導因子の作用機構解明とG_1早期選択的抗腫瘍薬開発への応用
- 1998 - 1999 Linkage between G protein-coupled receptors and the Jak/STAT pathway in cardiovascular cells
- 1995 - 1997 Regulation of proliferatin in vascular endothelial and smooth muscle cells by the protein kinase C pathway
- 抗炎症薬に関する薬理学的研究
- 悪性腫瘍治療薬に関する薬理学的研究
- 循環器疾患治療薬に関する薬理学的研究
- Pharmacological research on anti-inflammatory drugs
- Pharmacological research on anticancer drugs
- Pharmacological research on cardiovascular drugs
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Papers (78):
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Masaki Arioka, Fumi Seto-Tetsuo, Takeru Inoue, Koichi Miura, Shin Ishikane, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells. Life sciences. 2023. 335. 122278-122278
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Takeru Inoue, Koichi Miura, Ruzhe Han, Fumi Seto-Tetsuo, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri. Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission. Journal of Pharmacological Sciences. 2023. 152. 1. 39-49
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Fumi Seto-Tetsuo, Masaki Arioka, Koichi Miura, Takeru Inoue, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri. DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells. International immunopharmacology. 2023. 117. 109913-109913
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Akie Hirata, Shin Ishikane, Fumi Takahashi-Yanaga, Masaki Arioka, Tasuku Okui, Chinatsu Nojiri, Toshiyuki Sasaguri, Naoki Nakashima. Increased risk of metastasis in patients with incidental use of renin-angiotensin system inhibitors: a retrospective analysis for multiple types of cancer based on electronic medical records. Hypertension Research. 2022. 45. 12. 1869-1881
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Fumi Seto-Tetsuo, Masaki Arioka, Koichi Miura, Takeru Inoue, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway. Oncogene. 2021. 40. 37. 5579-5589
more...
MISC (70):
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Miki Nonaka, Sachio Morimoto, Kengo Hayamizu, Toshiyuki Sasaguri. Effect of pimobendan on heart failure at different stages in a mouse model of inherited cardiomyopathy. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 106P-106P
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Ai Fujita, Fumi Takahashi, Sachio Morimoto, Toshiyuki Sasaguri. Celecoxib and 2,5-dimethyl-celecoxib inhibit cardiac hypertrophy induced by transverse aortic constriction in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 157P-157P
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Miki Nonaka, Sachio Morimoto, Toshiyuki Sasaguri. Pimobendan has a preventive effect on compensated heart failure but increases the risk of sudden cardiac death at end-stage heart failure. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 241P-241P
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Kentaro Jingushi, Fumi Takahashi, Toshihisa Nakamura, Toshiyuki Sasaguri. Differentiation-inducing factor-1 suppressed the expression of c-Myc in human colon cancer cell line, HCT-116. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 174P-174P
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Miki Nonaka, Sachio Morimoto, Lei Li, Yutaka Kitamura, Toshiyuki Sasaguri. Therapeutic effect of pimobendan on end-stage heart failure in a mouse model of dilated cardiomyopathy. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 241P-241P
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Works (6):
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血流刺激の情報伝達機構に関する研究
1997 - 2001
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Study on the signal transduction of blood flow
1997 - 2001
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粘菌由来細胞分化誘導因子の情報伝達機構に関する研究
1998 - 2000
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Study on the signal transduction of dictyostelium differentiation-inducing factor
1998 - 2000
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一酸化窒素の情報伝達機構に関する研究
1995 - 1997
more...
Education (4):
- - 1987 Kyushu University
- - 1987 Kyushu University Graduate School, Division of Medicine
- - 1981 Kyushu University School of Medicine
- - 1981 Kyushu University Faculty of Medicine
Professional career (1):
- (BLANK) (Kyushu University)
Work history (6):
- 1993 - 2001 国立循環器病センター研究所室長
- 1993 - 2001 National Cardiovascular Center Research Institute, Division Head
- 1990 - 1993 国立循環器病センター研究所科学技術特別研究員
- 1990 - 1993 National Cardiovascular Center Research Institute, Researcher
- 1986 - 1988 University of Oxford
- 1986 - 1988 Oxford University, Research Assistant
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Committee career (4):
- 日本動脈硬化学会 評議員
- 日本高血圧学会 評議員
- 日本臨床薬理学会 評議員、理事
- 日本薬理学会 学術評議員
Association Membership(s) (7):
日本癌学会
, 日本循環器学会
, 日本内科学会
, 日本動脈硬化学会
, 日本高血圧学会
, 日本臨床薬理学会
, 日本薬理学会
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