2020 - 2023 Establichment of control method for M2-type activated macrophage-mediated progression of childhood CKD.
2020 - 2023 The study for the role of tryptophan metabolism in diabetic nephropathy-associated cognitive disorder
2019 - 2022 Elucidation of the role of tryptophan metabolism in diabetic nephropathy: Towards a development of novel treatment of diabetic nephropathy targeting tryptophan metabolism
2018 - 2021 Research on the key factors and signal transduction cascades of the onset of chronic kidney disease (CKD): Application of global omics technologies.
2017 - 2019 Evaluation of the postmortem lung change using rat euthanasia model and small animal X-ray CT
2016 - 2019 Ameriolation of progression of polycystic kidney disease by stabilization of renal vessel disorders and exploration of endogenous retrovirus responses in macrophages
2015 - 2018 Omics analysis applicable to preemptive medicine of chronic kidney disease -focusing on comprehensive analysis of phosphorylated proteins-
2013 - 2016 Creation of a novel device for renal regeneration by the interaction of a nonwoven filters and cells.
2012 - 2015 A study of molecular pathogenesis of chronic pancreatitis by using polycystic kidney rat
2012 - 2015 Basic studies of therapeutic modality for polycystic kidney disease explored by epigenetic modification of cellular matrix-adhesion proteins
2010 - 2012 A novel therapeutic approach for cystic disease:Inhibition of intracellular signal transduction pathways by a nuclear receptor cascade
2010 - 2012 The clarify of the mechanism of induction of immunological tolerance using mouse liver transplantation model and development of novel immunosuppression.
2009 - 2011 Mechanisms for Ca2+ absorption by pancreatic ductal epithelium : A study looking for a new strategy to prevent pancreatic stone formation.
2004 - 2006 Molecular pathogenesis of chronic pancreatitis: CFTR and intraductal sensor molecules
1990 - 1992 Study of the pathogenesis of progressive hereditary PKD mouse
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Papers (120):
Saori Fukuda, Masanori Kugita, Kanako Kumamoto, Yuki Akari, Yuki Higashimoto, Shizuko Nagao, Takayuki Murata, Tetsushi Yoshikawa, Koki Taniguchi, Satoshi Komoto. Generation of Recombinant Authentic Live Attenuated Human Rotavirus Vaccine Strain RIX4414 (Rotarix®) from Cloned cDNAs Using Reverse Genetics. Viruses. 2024. 16. 8
Yoshiki Kawamura, Satoshi Komoto, Saori Fukuda, Masanori Kugita, Shuang Tang, Amita Patel, Julianna R Pieknik, Shizuko Nagao, Koki Taniguchi, Philip R Krause, et al. Development of recombinant rotavirus carrying herpes simplex virus 2 glycoprotein D gene based on reverse genetics technology. Microbiology and immunology. 2024. 68. 2. 56-64
Takahiro Matsuyama, Seiichiro Ota, Yoshitaka Inui, Naoko Fujii, Tetsuya Tsukamoto, Ichiro Isobe, Katsumi Tsujioka, Shizuko Nagao, Ryosuke Tanabe, Hiroshi Toyama. Examination of postmortem changes in the lungs, trachea, and bronchi in a rat model imaged with small-animal computed tomography. Fujita medical journal. 2023. 9. 2. 101-104
Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, et al. High salt induces cognitive impairment via the interaction of angiotensin II-AT1 and prostaglandin E2-EP1 systems. British journal of pharmacology. 2023. 180. 18. 2393-2411
Shizuko Nagao, Tamio Yamaguchi. Review of the Use of Animal Models of Human Polycystic Kidney Disease for the Evaluation of Experimental Therapeutic Modalities. Journal of clinical medicine. 2023. 12. 2
Comparative Transcriptome Analysis of Spontaneously Diabetic Torii Fatty Rat Undergoing Salt Loading Alone or with Unilateral Nephrectomy
(Week 2023 Annual Meeting 2023)
Sox2/CD63-GFP transgenic rat: A novel model for nephrogenic diabetes insipidus
(Kidney Week 2023 Annual Meeting 2023)
Exploring progression factors of nephropathy in an obesity-associated type 2 diabetes rat model
(University of Manitoba, Canadian Centre for Agri-Food Research in Health and Medicine Seminar 2023)
2012/10 - 現在 Fujita Health University Graduate school Professor
2012/10 - 現在 Fujita Health University Advanced Medical Research Center for Animal Model of Human Diseases Professor
2008/04 - 現在 Fujita Health University Advanced Medical Research Center for Animal Model of Human Diseases
1998/09 - 2000/08 U.S.A. University of Kansas Medical Center Kidney Institute Visiting Assistant Professor
Committee career (9):
2024 - 現在 公私立大学実験動物施設協議会 理事
2018 - 現在 公私立大学実験動物施設協議会 動物実験適正化委員
2017 - 現在 日本実験動物学会 外部検証訪問調査委員
2014 - 現在 公私立大学実験動物施設協議会 役員
2014 - 現在 公私立大学実験動物施設協議会 アドバイザー委員長
2022 - 2024 公私立大学実験動物施設協議会 監事
2014 - 2017 公私立大学実験動物施設協議会 動物実験に関する相互検証プログラム専門委員
2007 - 2014 公私立大学実験動物施設協議会 組織・制度検討委員会委員
2004 - 2007 公私立大学実験動物施設協議会 医学研究と実験動物の近未来検討委員
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Awards (3):
2016/09 - The Asian Pacific Society of Nephrology Young Investigator Award Mitochondrial dysfunction contributes to cyst proliferation of autosomal dominant polycystic kidney disease.