Rchr
J-GLOBAL ID：200901024029772589
Update date: Sep. 26, 2024
Yamaguchi Hiroyuki
ヤマグチ ヒロユキ | Yamaguchi Hiroyuki
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.hs.hokudai.ac.jp/yamaguchi/
Research field (1)：
Bacteriology
Research theme for competitive and other funds (32)：
- 2022 - 2025 Functional elucidation of novel effectors of Legionella pneumophila approached through interactions with unique ciliate
- 2021 - 2025 New development of research to elucidate the intracellular adaptation mechanism of genital chlamydia unraveled from its similarity to cancer cells
- 2020 - 2024 入院患者の日常生活動作レベルがベッド周辺環境の微生物汚染に及ぼす影響
- 2020 - 2024 Understanding and application of microbiota in building environment: creation of pathogen control theory by temperature control
- 2019 - 2022 Host DNA damage responses and the regulations in chlamydial infections
- 2019 - 2020 第51回内藤記念科学奨励金研究助成
- 2014 - 2019 Methods for the analysis and control of biomolecules in living cells based on molecular imaging
- 2016 - 2019 アメーバ共生細菌原始クラミジアのレジオネラ撃退に関わる分子マシナリーの探索 研究課題
- 2016 - 2019 腟菌叢とメタボローム: クラミジア卵管線維化機構とPID診断バイオマーカーの探索
- 2016 - 2018 Effect of bacterial signal molecule AI-2 on the metabolism and pathogenicity of protozoa
- 2015 - 2018 Regulations of inflammatory responses induced by Chlamydia
- 2011 - 2016 Molecular basis of the intracellular life of bacteria within eukaryotic cells
- 2014 - 2016 原始クラミジアが共生するアメーバは何故レジオネラの感染から回避できるのか
- 2013 - 2015 Search of the predictive diagnosis marker of the Chlamydia infection, using a pathological experiment.
- 2013 - 2014 原始クラミジアエフェクターの機能解析から紐解く病原体の新規制御システムの探索
- 2012 - 2013 アメーバに共生する難培養性細菌のゲノム解析から紐解くマトリョーシカ進化原理
- 2012 - 2013 アメーバ共生細菌プロトクラミジアアンキリンエフェクターの機能解析
- 2009 - 2011 Molecular mechanism of pathogenic chlamydial infection to lymphocytes
- 2009 - 2010 Clinical studies, immunological analysis, and antigen structure analysis about Alloiococcus otitidis
- 2005 - 2006 Chlamydia pneumoniae persistent infection and its mechanism
- 2003 - 2004 Chlamydia pneumoniae dissemination and atherosclerosis
- 2000 - 2001 Pathogenic role of heat shock protein of Helicobacter pylori and host immune response to the heat shock protein
- 1999 - 1999 細菌病原因子としての分子シャペロン-DnaK およびGroEL による病原細菌表層構造構築の分子機構-
- 1997 - 1998 無菌マウスを用いた腸管出血性大腸菌感染症・病態解析モデルの開発
- 1997 - 1998 Study on pathogenecity of Helicobacter pylori in gastroduodenum using germ-free mice.
- 1997 - 1998 ヘリコバクター・ピロリ熱ショック蛋白の胃・十二指腸慢性炎症反応における役割
- 1996 - 1998 Role of Stress Protein on Bacterial Infection
- 1995 - 1996 Analysis for the mechanism of gastric mucosal damage by Helicobacter pylori infection
- 1995 - 1995 Helicobacter pylori熱ショック蛋白の精製,製造解析と発現機構
- 1994 - 1995 Studies on the Bacterial Stress Proteins as Virulence Fctors
- 1993 - 1994 Purification and characterization of cytotoxin produced by H.phlori, and mechanisms for the occurrence of gastroduodenal diseases by H.pylori infection.
- 1992 - 1993 Studies on the Bacterial Stress Proteins as Virulence Factors
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Papers (104)：
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Ruiyu Li, Saicheng Zhang, Satoko Otsuguro, Manabu Nagao, Akira Matsuda, Jeewan Thapa, Torahiko Okubo, Katsumi Maenaka, Hideaki Higashi, Hiroyuki Yamaguchi. Chlamydia trachomatis L2 434/Bu readily activates glycolysis under hypoxia for efficient metabolism. Biochemical and Biophysical Research Communications. 2024. 150461-150461
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Hiroyuki Yamaguchi, Torahiko Okubo, Eriko Nozaki, Takako Osaki. Differential impact of environmental factors on airborne live bacteria and inorganic particles in an underground walkway. PloS one. 2024. 19. 3. e0300920
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Ayano Konno, Torahiko Okubo, Yoshiaki Enoeda, Tomoko Uno, Toyotaka Sato, Shin-Ichi Yokota, Rika Yano, Hiroyuki Yamaguchi. Human pathogenic bacteria on high-touch dry surfaces can be controlled by warming to human-skin temperature under moderate humidity. PloS one. 2023. 18. 9. e0291765
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Saicheng Zhang, Yuki Funahashi, Satoho Tanaka, Torahiko Okubo, Jeewan Thapa, Shinji Nakamura, Hideaki Higashi, Hiroyuki Yamaguchi. Chlamydia trachomatis relies on the scavenger role of aryl hydrocarbon receptor with detyrosinated tubulin for its intracellular growth, but this is impaired by excess indole. Microbes and Infection. 2023. 25. 5. 105097-105097
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Ryoya Tsujikawa, Jeewan Thapa, Torahiko Okubo, Shinji Nakamura, Saicheng Zhang, Yoshikazu Furuta, Hideaki Higashi, Hiroyuki Yamaguchi. Chlamydia trachomatis L2/434/Bu Favors Hypoxia for its Growth in Human Lymphoid Jurkat Cells While Maintaining Production of Proinflammatory Cytokines. Current Microbiology. 2022. 79. 9
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MISC (47)：
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ZHANG Saicheng, 大久保寅彦, 中村眞二, 東秀明, 山口博之. Pathogenic Chlamydia L2 requires aryl hydrocarbon receptors and detyrosinated tubulin for its growth. 日本細菌学雑誌(Web). 2023. 78. 1
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矢野 理香, 山口 博之, 松尾 淳司, 大久保 寅彦, 良村 貞子, 下田 智子. マイクローブトランスファー 身の回りの環境に潜む病原細菌の生態deja vuと健康リスク 病院での環境清浄度評価の盲点と院内細菌叢の実態. 日本細菌学雑誌. 2016. 71. 1. 56-56
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Enhanced survival of Helicobacter pylori in co-culture with Acanthamoeba castellanii and the expressions of bacterial genes. 2016. 46. 2. 62-64
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F. Hojo, T. Osaki, H. Yonezawa, S. Kurata, T. Hanawa, H. Yamaguchi, S. Kamiya. SURVIVAL STRATEGY OF HELICOBACTER PYLORI IN ENVIRONMENTS BY CO-EXISTENCE IN ACANTHAMOEBA CASTELLANII. HELICOBACTER. 2014. 19. 103-103
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YAMAGUCHI HIROYUKI, MATSUO JUNJI, SEKIZUKA TSUYOSHI, KURODA MAKOTO, NAGAI HIROKI, SUGIMOTO CHIHIRO. Comparative genomics of primitive chlamydiae showing distinct mutualistic symbiosis with amoebae. 日本細菌学雑誌. 2013. 68. 1. 186
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Lectures and oral presentations (39)：
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Search for new target molecules used by Chlamydia trachomatis (L2 434/Bu strain) in infected cells by screening approved drug libraries
(第97回日本細菌学会総会(札幌) 2024)
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乾燥面での付着菌数を低減させる温度条件とその応用:加温便座の有効性の検討
(第97回日本細菌学会総会(札幌) 2024)
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Chlamydia trachomatisが感染細胞内で利用するMAPKおよび PI3K-AKT経路に付随する新たな標的分子の探索
(第97回日本細菌学会総会(札幌) 2024)
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選抜WS3-8: クラミジア・トラコマティスはメチオニン関連代謝が抑制される低酸素環境を好む
(第97回日本細菌学会総会(札幌) 2024)
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偏性細胞内寄生性細菌クラミジアのヒト細胞内への適応機構
(第72回日本感染症学会東日本地方会学術集会 (教育講演12) 2023)
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Education (1)：
- - 1983 Kyorin University Faculty of Health Care
Professional career (1)：
Association Membership(s) (3)：
日本臨床検査学教育学会
, American Society for Microbiology
, 日本細菌学会
