J-GLOBAL ID:200901024441064610   Update date: Nov. 19, 2019


マスタニ ヒロシ | MASUTANI Hiroshi
Affiliation and department:
Job title: Professor
Homepage URL  (2): https://www.researchgate.net/profile/Hiroshi_Masutanihttps://www.researchgate.net/profile/Hiroshi_Masutani
Research field  (5): Pathological medical chemistry ,  Experimental pathology ,  General medical chemistry ,  Molecular biology ,  Hematology
Research keywords  (23): ARRDC4 ,  ARRDC3 ,  ARRDC1 ,  tau ,  dementia ,  Alzheimer's disease ,  thioredoxin ,  TBP-2 ,  Nrf2 ,  Txnip ,  redox ,  thioredoxin (TRX) ,  thioredoxin 2 ,  ARE ,  thioredoxin 2 (TRX2) ,  NGF ,  apoptosis ,  TBP-2/Txnip ,  3-methylcholanthrene ,  Cancer Research ,  Energy Metabolism ,  Molecular Biology ,  Biochemistry
Research theme for competitive and other funds  (8):
  • 2005 - 2006 Analysis of the mechanism and biological function of the internalization of thioredoxin into cells via lipid raft.
  • 2001 - 2002 Investigation of biological function of thioredoxin by construction of thioredoxin knock down mice
  • 2004 - 2005 Effect of oxidative stress and redox-regulating proteins on tumor growth and chemosensitivity
  • 2003 - 2005 The study on the regulation of cellular growth and aging process by thioredoxin binding protein
Show all
Papers (137):
  • Cristiane Lumi Hirata, Shinji Ito, MASUTANI Hiroshi. Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes. Archives of Biochemistry and Biophysics. 2019. 677. 108159
  • Hiroshi MASUTANI and Cristiane Lumi HIRATA. Recent advances regarding role of thioredoxin, Txnip, and ARRDC3 in cancer and other diseases. Bulletin of Tenri Health Care University. 2018
  • Yodoi J, Matsuo Y, Tian H, Masutani H, Inamoto T. Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care. Nutrients. 2017. 9. 10
  • Mogami H, Yura S, Kondoh E, Masutani H, Yodoi J, Konishi I. Differential expression of thioredoxin binding protein-2/Txnip in human placenta: Possible involvement of hypoxia in its suppression during early pregnancy. J Obstet Gynaecol Res. 2017. 43. 1. 50-56
  • MASUTANI Hiroshi. Thiol redox barrier; local and systemic surveillance against stress and inflammatory diseases. Arch Biochem Biophys. 2016. 595. 88-93
MISC (144):
Books (7):
  • ADF(adult T cell derived factor)/human thioredoxin and viral intection : possible new therapentic approach.
    Microbial Infections Role of Biological Response Modifiers. edited by Herrman Fridman. Prennm press 1992
  • Antioxidant and Redox Regulation of Genes.
    Academic Press 2000
  • Role of thioredoxin family in the redox regulation of oxidative stress response and signalling. In ′′Antioxidant and Redox regulation of genes. ′′edited by Chandan K. Sen, Helmut Sies and Patrick A. Baeuerle (jointly authored)
    Baeurele, Academic press 2000
  • Thioredoxin-dependent redox regulation in biological responses. In" Free Radicals in Chemistry, Biology and Medicine" edited by
    Y. OICA International, London 2000
  • Environmental Stressors in Health and Disease
    Marcel Dekker 2001
Lectures and oral presentations  (36):
  • Nerve growth factor can activate the serum response element of the c-fos promoter independently of SRF.
    (EMBL Meeting on Transcription 1996)
  • Nerve growth factor can activate the c-fos serum response element independently of SRF
    (Meeting on Oxidative stress and redox regulation: Cellular signaling, AIDS, Cancer and Other Diseases 1996)
  • Transactivation of an inducible anti-oxidative stress protein, human thioredoxin (TRX) by HTLV-I Tax
    (Masutani H, Sasada T, Ueda-Taniguchi Y, Taniguchi Y, Sono H, Yodoi J. 1997)
  • Characterization of the oxidative responsive element (ORE) in the thioredoxin promoter
    (1998 annual meeting of the Oxygen club of California 1998)
  • 細胞機能のレドックス制御メカニズム
    (10th forum in Dojin、生体と酸化還元 1999)
Education (2):
  • - 1985 Kyoto University Faculty of Medicine
  • - 1992 Kyoto University Graduate School, Division of Medicine
Professional career (1):
  • Doctor of Medicine, PhD (Kyoto University)
Work history (3):
  • 2004 - associate professor
  • 1992 - assistant professor
  • 2017/04 - 現在 Tenri Health Care University Professor
Association Membership(s) (7):
Japanese Cancer Association ,  Japanese Immunology Society ,  Japanese hematology association ,  Japanese Biochemical Association ,  Japanese molecular biology association ,  Japanese internal medicine society ,  SFRR Japan
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