J-GLOBAL ID:200901024441064610   Update date: May. 31, 2020

Masutani Hiroshi

増谷 弘 | Masutani Hiroshi
Affiliation and department:
Job title: Professor
Homepage URL  (2): https://www.researchgate.net/profile/Hiroshi_Masutanihttps://www.researchgate.net/profile/Hiroshi_Masutani
Research field  (5): Pathobiochemistry ,  Experimental pathology ,  Medical biochemistry ,  Hematology and oncology ,  Molecular biology
Research keywords  (23): ARRDC4 ,  ARRDC3 ,  ARRDC1 ,  tau ,  dementia ,  Alzheimer's disease ,  thioredoxin ,  TBP-2 ,  Nrf2 ,  Txnip ,  redox ,  thioredoxin (TRX) ,  thioredoxin 2 ,  ARE ,  thioredoxin 2 (TRX2) ,  NGF ,  apoptosis ,  TBP-2/Txnip ,  3-methylcholanthrene ,  Cancer Research ,  Energy Metabolism ,  Biochemistry ,  Molecular Biology
Research theme for competitive and other funds  (8):
  • 2005 - 2006 Analysis of the mechanism and biological function of the internalization of thioredoxin into cells via lipid raft.
  • 2004 - 2005 Effect of oxidative stress and redox-regulating proteins on tumor growth and chemosensitivity
  • 2003 - 2005 The study on the regulation of cellular growth and aging process by thioredoxin binding protein
  • 2001 - 2002 Investigation of biological function of thioredoxin by construction of thioredoxin knock down mice
Show all
Papers (143):
  • Tomonori Soyama, Hiroshi Masutani, Cristiane Lumi Hirata, Eri Iwai-Kanai, Takashi Inamoto. Thioredoxin as a novel sensitive marker of biological stress response in smoking. Journal of Clinical Biochemistry and Nutrition. 2020
  • Cristiane Lumi Hirata, Shinji Ito, Hiroshi Masutani. Dataset on the formation of Thioredoxin interacting protein (Txnip) containing redox sensitive high molecular weight nucleoprotein complexes. Data in brief. 2020. 28. 104893-104893
  • Michiyuki Maeda, Junko Tanabe-Shibuya, Paola Miyazato, Hiroshi Masutani, Jun-Ichirou Yasunaga, Kazumasa Usami, Akira Shimizu, Masao Matsuoka. IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia. Frontiers in microbiology. 2020. 11. 356-356
  • Cristiane Lumi Hirata, Shinji Ito, Hiroshi Masutani. Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes. Archives of biochemistry and biophysics. 2019. 677. 108159. 108159-108159
  • Hiroshi MASUTANI, Cristiane Lumi HIRATA. Recent advances regarding role of thioredoxin, Txnip, and ARRDC3 in cancer and other diseases. Bulletin of Tenri Health Care University. 2018
MISC (145):
Books (7):
  • Molecular Interventions in Lifestyle-Related Diseases
    Taylor & Francis 2006
  • Regulation of gene expression and transcription factors in response to environmental oxidants. In ′′environmental stressors : Effects on Lung, Skin, Eye and Immune System Function′′ edited by J(]E88DB[)rgen FUCHS and Lester PACKER
    Marcel Dekker Inc. New York. 2001
  • Environmental Stressors in Health and Disease
    Marcel Dekker 2001
  • Thioredoxin-dependent redox regulation in biological responses. In" Free Radicals in Chemistry, Biology and Medicine" edited by
    Y. OICA International, London 2000
  • Role of thioredoxin family in the redox regulation of oxidative stress response and signalling. In ′′Antioxidant and Redox regulation of genes. ′′edited by Chandan K. Sen, Helmut Sies and Patrick A. Baeuerle (jointly authored)
    Baeurele, Academic press 2000
Lectures and oral presentations  (28):
  • Thioredoxin interacting protein (Txnip) forms high molecular weight ribonucleoprotein complexes in cancer cells
    (THe 27th Annual Meeting of the Japanese Society for Cell Death Research 2018)
  • Development of drugs against anti-diabetes and recognition disorders based on Txnip
  • Thioredoxin interacting protein (Txnip) High order complex formation in cancer cells
  • Development of redox modulating approaches against cancer and diabetes by Thioredoxin binding protein-2 (TBP-2) /Txnip
    (17th Biennial Meeting of Society for Free Radical Research International 2014)
  • Thioredoxin binding protein-2 (TBP-2)/ Txnip/ VDUP1 with multifunctional biostress signal regulatory activities
Education (3):
  • - 1992 Kyoto University Graduate School, Division of Medicine
  • - 1985 Kyoto University Faculty of Medicine Department of Medical Science
  • - 1985 Kyoto University Faculty of Medicine
Professional career (1):
  • Doctor of Medicine, PhD (Kyoto University)
Work history (4):
  • 2017/04 - 現在 Tenri Health Care University Professor
  • 2011 - 2013 Kyoto University
  • 2004 - - associate professor
  • 1992 - - assistant professor
Association Membership(s) (7):
SFRR Japan ,  Japanese internal medicine society ,  Japanese molecular biology association ,  Japanese Biochemical Association ,  Japanese hematology association ,  Japanese Immunology Society ,  Japanese Cancer Association
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