Rchr
J-GLOBAL ID：200901024729974107
Update date: Oct. 31, 2024
Imamura Hiromi
イマムラ ヒロミ | Imamura Hiromi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://sites.google.com/view/imamura-lab/
Research field (3)：
Biophysics
, Functional biochemistry
, Structural biochemistry
Research keywords (3)：
バイオセンサー
, 蛍光イメージング
, エネルギー代謝
Research theme for competitive and other funds (23)：
- 2024 - 2027 還元的手法と構成的手法を組合せた蛍光蛋白質の設計原理の解析と新規蛍光蛋白質開発
- 2022 - 2025 細胞内アミノ酸ダイナミクスのリアルタイム可視化によるがん幹細胞維持シグナルの解明
- 2020 - 2023 光熱変換を利用した細胞操作技術の開発
- 2020 - 2023 Next generation non-invasive deep biological manipulation by combining biomolecular engineering and low physical energy logistics
- 2020 - 2023 試験管内分子進化と立体構造解析に基づいた赤色蛍光タンパク質の系譜拡張
- 2020 - 2022 Construction of photosynthetic zebrafish
- 2019 - 2022 Study on the remodeling of energy metabolism of cancer cells with a novel technology of isolating cells based on ATP concentrations
- 2018 - 2021 人工生体分子反応回路を埋め込んだ紙基板バイオアッセイ法の開発
- 2017 - 2020 Study of mitochondrial transporters branched-chain amino acids using genetically encoded fluorescent biosensors
- 2014 - 2019 Prevention, diagnosis and drug discovery of aging diseases using Pin1 related molecules
- 2016 - 2018 Quantitative analysis of ATP dynamics in photosynthetic organisms by a novel bioluminescence ATP biosensor
- 2015 - 2017 遺伝子コードされたFRET型酸素バイオセンサーの開発
- 2014 - 2017 Spatio-temporal analysis of extracellular ATP signaling of pancreatic islets
- 2013 - 2016 Functional analysis of pancreatic beta-cells in metabolic disorders using the fluorescent ATP probe gene transgenic mouse
- 2014 - 2015 Energy dynamics during kidney development, injury and regeneration
- 2014 - 2015 Development of efficient protein production system by photo-driven ATP regenerating vesicle
- 2012 - 2015 Development of neuroprotective treatment for incurable ocular diseases
- 2012 - 2014 Development of methods to visualize small conformational change of proteins inside cells
- 2011 - 2014 Analyses of the function and regulation of VCP, a major ATPase in the cells
- 2011 - 2012 Comprehensive quantification and visualization of energy metabolism in cell competition between dying and living cells.
- 2010 - 2012 Analysis of the roles of intracellular ATP during apoptosis by using the ATP imaging technique.
- 2010 - 2012 Real-time measurement of intracellular ATP concentration using novel fluorescent ATP probe.
- 蛍光生細胞イメージングを用いたエネルギー代謝の解析
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Papers (126)：
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Shigenori Yamamoto, Shinya Yamamoto, Masahiro Takahashi, Akiko Mii, Akihiro Okubo, Naoya Toriu, Shunsaku Nakagawa, Takaaki Abe, Shingo Fukuma, Hiromi Imamura, et al. Visualization of intracellular ATP dynamics in different nephron segments under pathophysiological conditions using the kidney slice culture system. Kidney international. 2024
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Hiromi Imamura, Shiho Otsubo, Mizuho Nishida, Norihiro Takekawa, Katsumi Imada. Red fluorescent proteins engineered from green fluorescent proteins. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 45. e2307687120
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Pailin Chiaranunt, Kyle Burrows, Louis Ngai, Siu Ling Tai, Eric Y Cao, Helen Liang, Homaira Hamidzada, Anthony Wong, Julia Gschwend, Pascal Flüchter, et al. Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling. Science immunology. 2023. 8. 86. eabq4573
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Jungmi Choi, Naoki Matoba, Daiki Setoyama, Daiki Watanabe, Yuichiro Ohnishi, Ryuto Yasui, Yuichirou Kitai, Aki Oomachi, Yutaro Kotobuki, Yoichi Nishiya, et al. The SGLT2 inhibitor empagliflozin improves cardiac energy status via mitochondrial ATP production in diabetic mice. Communications biology. 2023. 6. 1. 278-278
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Masak Takaine, Hiromi Imamura, Satoshi Yoshida. High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast. eLife. 2022. 11
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MISC (51)：
Lectures and oral presentations (18)：
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緑色蛍光タンパク質由来赤色蛍光タンパク質の創出
(第21回日本蛋白質科学会年会 2021)
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イメージングで生細胞内の代謝物動態を明らかにする
(農芸化学会2021年度大会 2021)
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アポトーシスにおいてパネキシン1によって駆動されるプログラムされたATP減少の単一細胞イメージング
(第12回光塾 2020)
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Genetically encoded fluorescent biosensors for understanding of metabolism at single cell level
(2nd WPI-NanoLSI Special Seminar -Frontiers in Chem-Bio- 2020)
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蛍光変化のダイナミックレンジを増大させたFRET型バイオセンサー開発
(日本生体エネルギー研究会第45回討論会 2019)
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Education (3)：
- 1997 - 2002 The University of Tokyo Graduate School of Agricultural and Life Sciences Department of Biotechnology
- 1995 - 1997 The University of Tokyo
- 1993 - 1995 The University of Tokyo College of Arts and Sciences
Professional career (1)：
Work history (7)：
- 2024/09 - 現在 Yamaguchi University Organization for Research Initiatives Sience Research Center Professor
- 2015/04 - 2024/08 Kyoto University Graduate School of Biostudies Associate Professor
- 2012/04 - 2015/03 Kyoto University Hakubi Center for Advanced Research Associate Professor
- 2011/04 - 2012/03 Kyoto University
- 2007/10 - 2011/03 Japan Science and Technology Agency
- 2006/03 - 2007/09 Osaka University The Institute of Scientific and Industrial Research
- 2002/04 - 2006/03 Japan Science and Technology Agency ERATO Yoshida ATP System Proect
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Awards (3)：
- 2019/02 - 公益財団法人 中谷医工計測技術振興財団 中谷賞奨励賞
- 2016/04 - 公益財団法人 長瀬科学技術振興財団 長瀬科学技術振興賞
- 2007/12 - 日本生物物理学会 生物物理学会若手奨励賞
Association Membership(s) (4)：
日本細胞生物学会
, 米国生物物理学会
, 日本蛋白質科学会
, 日本生物物理学会
