Ohara Naoya

2019 - 2022 Elucidation of biofilm formation mechanism via signal transduction system of mycobacteria

2017 - 2022 The mechanism of periodontal tissue destruction by proteases from periodontal bacteria Porpyromonas gingivalis.

2017 - 2021 Understanding the pathogenicity of periodontal disease onset and systemic disease exacerbation caused by periodontal bacteria

2016 - 2018 Analysis the virulence of Mycobacterium tuberculosis based of rapid-growing BCG

2015 - 2018 Effects of Multilineage-differentiating stress-enduring (Muse) cells on brain damages induced by Shiga toxin 2 in vivo and in vitro

2015 - 2018 Development of a novel root caries treatment by bacterial inactivation factor

2014 - 2017 Molecular mechanisms of periodontal diseases and systematic diseases associated with periodontal diseases by periodontal pathogens

2014 - 2017 Development of new periodontal disease prevention method using ECF sigma factors of periodontal pathogenic bacteria

2013 - 2016 Analysis of mechanism of T cell targeting into Mycobacterium tuberculosis-infected lung and development of new lung-targeting vaccine strategy

2012 - 2015 TraSH法による歯周病原細菌の宿主細胞内防御系からの回避機構の解明

2012 - 2015 Kinetic analysis of cariogenic bacteria on root dentin caries

2012 - 2015 Molecular imaging analysis of the antitumour activity of 5-fluorouracil combine with Mycobacterium bovis bacillus Calmette-Guérin (BCG) in the mouse oral cancer model.

2012 - 2014 The application of bacterial biomineralization to sealed restoration

2011 - 2013 receptor

2011 - 2012 新興・再興感染症を標的としたプライムブーストワクチンの開発と有効性・安全性評価システムの構築

2010 - 2012 Study on the survival strategies for periodontal bacteria in host cells and their role in the pathogenesis of periodontal diseases

2010 - 2012 Investigation on the automation and speeding up ofmeasurement of the plasma IgG antibody titers against periodontopathic bacteria

2010 - 2012 Development of prevention and treatment methods for infection by enterohemorrhagic Escherichia coli O157 based on bio-protect ive mechanisms

2006 - 2009 The study of the mechanism of therapeutic efficacy of novel vaccines on Tuberculosis-infection and the induction of cytotoxic T cells by the vaccines

2007 - 2008 Analysis of molecular mechanism of bone metabolism disruption by bacterial infection

2007 - 2008 Hydrogen Sulfide Production from Cysteine and Homocysteine by Periodontal and Oral Bacteria

2006 - 2007 Study for gignipain-related adhesins of Periodontal pathogen, Porphyromonas gingivalis for its platelet aggregation activity

2005 - 2007 Molecular Mechanisms of Interaction between Periodontitis and Cardiovascular and Bone Metabolic Disorders

2005 - 2005 P.gingivalisの生体内環境における病原性発現調節機構の解析

2004 - 2005 口腔慢性細菌感染の心血管系および骨代謝系への影響とその病原因子に関する研究

2004 - 2005 Study on the oxidative stress responses of a major periodontopathogenic bacteria

2002 - 2004 Pest-sequencing analysis of periodontal pathogen Porphyromonas gingivalis : expression of its proteins by oral environmental fectors.

2002 - 2004 Establishment of Novel (DNA-recombinant BCG-, and fusion protein-)vaccination against Tuberculosis and analysis of novel differentiation mechanism of cytotoxic T cell

2003 - 2003 歯周病原細菌菌体表面タンパクの心血管系および骨代謝系に及ぼす影響

2001 - 2003 Investigation of New Drugs that Inhibit Acquisition of Iron from Oral Environments in the Periodontopathogen Porphyromonas gingivalis.

2001 - 2002 Identification of HLA-restricted cytotoxic T cell epitopes of Mycobcaterium tuberculosis for developing epitope vaccines

1999 - 2000 歯周病原細菌における低分子ストレスタンパク質による広範囲調節機構の解析

1997 - 2000 A study for non-specific or specific immunochemotherapy by using recombinant BCG

1998 - 1998 マラリアのワクチン開発を目指した,BCGからのSERA抗原発現の試み

1997 - 1998 歯周疾患関連菌に新しく発見された挿入配列の病原性への関与

1997 - 1998 う蝕の遺伝子治療に関する基礎的研究

1995 - 1995 歯周病関連菌リボゾーム画分に存在する免疫活性物質の研究

1994 - 1994 歯周病関連菌のリボゾーム蛋白質の歯周疾患発症における意義

1992 - 1994 Studies for the Development of Recombinant BCG and for the Structure and Function of Secreting Proteins in Mycobacteria

1991 - 1991 歯周病発病の分子機構の研究(口腔細菌のストレス蛋白質遺伝子の構造と機能)

薬剤耐性結核および非結核性抗酸菌治療薬開発を加速する支援技術の開発