Rchr
J-GLOBAL ID:200901025290855765   Update date: May. 27, 2020

Okumura Fumihiko

オクムラ フミヒコ | Okumura Fumihiko
Affiliation and department:
Research field  (1): Pharmaceuticals - health and biochemistry
Research keywords  (5): interferon ,  protein translation ,  innate immune system ,  ISG15 ,  ubiquitin
Papers (31):
  • Nakatsukasa Kunio, Sone Megumi, Alemayehu Dawit Hailu, Okumura Fumihiko, Kamura Takumi. The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase. FEBS LETTERS. 2018. 592. 10. 1716-1724
  • Okumura F, Joo-Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T. Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Mol. Biol. Cell. 2017. 15. 28(24). 3532-3541
  • Okumura F, Joo-Okumura A, Nakatsukasa K, Kamura T. Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2. PLoS One. 2017. 10. 12(4)
  • Keiji Uematsu, Fumihiko Okumura, Syunsuke Tonogai, Akiko Joo-Okumura, Dawit Hailu Alemayehu, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura. ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. JOURNAL OF CELL BIOLOGY. 2016. 215. 1. 95-106
  • Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T. Parallel regulation of VHL disease by pVHL-mediated degradation of B-Myb and HIF-alpha. Mol. Cell. Biol. 2016. 36. (12). 1803-17
more...
MISC (31):
  • Nakatsukasa Kunio, Sone Megumi, Alemayehu Dawit Hailu, Okumura Fumihiko, Kamura Takumi. The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase. FEBS LETTERS. 2018. 592. 10. 1716-1724
  • Okumura F, Joo-Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T. Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Mol. Biol. Cell. 2017. 15. 28(24). 3532-3541
  • Okumura F, Joo-Okumura A, Nakatsukasa K, Kamura T. Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2. PLoS One. 2017. 10. 12(4)
  • Keiji Uematsu, Fumihiko Okumura, Syunsuke Tonogai, Akiko Joo-Okumura, Dawit Hailu Alemayehu, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura. ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. JOURNAL OF CELL BIOLOGY. 2016. 215. 1. 95-106
  • Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T. Parallel regulation of VHL disease by pVHL-mediated degradation of B-Myb and HIF-alpha. Mol. Cell. Biol. 2016. 36. (12). 1803-17
more...
Books (2):
  • Regulation of cellular functions by Elongin BC based E3 ubiquitin ligase
    2013
  • Regulation of immune response by ubiquitin-like molecule ISG15
    Seikagaku 2009
Lectures and oral presentations  (10):
  • Ubiquitin ligase ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation
    (2016)
  • Parallel regulation of VHL disease through degradation of FOB and HIF-α by pVHL
    (2014)
  • Regulation of protein translation by ISG15-modified PKR.
    (2013)
  • Activation of PKR by ubiquitin-like molecule ISG15 modification down-regulates protein translation
    (The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles. 2013)
  • Activation of double-stranded RNA-activated protein kinase (PKR) by interferon stimulated gene 15 (ISG15) modification down-regulates cap-dependent translation
    (2013)
more...
Work history (4):
  • 2016/10 - 2019/03 Nagoya University Graduate School of Science Division of Biological Science Genetic Mechanism Lecturer
  • 2011/04/01 - 2016/09/30 Nagoya University Assistant Professor
  • 2008/03 - 2011/03 Hokkaido University
  • 2005/04 - 2008/02 The Scripps research institute Research associate
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