Rchr

J-GLOBAL ID：200901025590560589 Update date: Sep. 25, 2024

Kadomatsu Kenji

カドマツケンジ | Kadomatsu Kenji

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.med.nagoya-u.ac.jp/biochem/

Research field (1)： Medical biochemistry

Research keywords (10)： chondroitin sulfate , keratan sulfate , sulfotransferase , chondroitin 6-O sulfotransferase , N-acetylglucosamin 6-O sulfotransferase , EMMPRIN , CD147 , baisigin , growth factor , midkine

Research theme for competitive and other funds (73)：

2017 - 現在細胞分裂期キナーゼ阻害にもとづく難治性神経芽腫の新規治療法開発
2017 - 現在癌検体の収集、実験データの取得および介入実験
2021 - 2024 A new concept of glycan signaling for cell regulation
2020 - 2023 Usefulness of Basigin as a novel therapeutic target for diabetic kidney and liver diseases
2019 - 2022 A new ligand for ALK and its activation mechanism

2018 - 2021 Molecular basis for KIR ligand-mismatched cord blood transplantation for advanced neuroblastoma

2017 - 2020 Elucidation of intracellular import and metabolic circuits involving CD147/Basigin and development of novel therapeutics through regulation of sugar chain modification

2017 - 2019 Functional analysis of ALK, a receptor-type protein tyrosine kinase in axonal regeneration

2016 - 2019 Intracellular signaling of TypeII a receptor tyrosine phospatase

2017 - 2019 MYCファミリー遺伝子高発現型がんを標的とした新規治療法開発(先端)

2015 - 2018 Sulf2-remodeling of heparan sulfate present in brain amyloids

2016 - 2018 抗Midkineモノクローナル抗体併用によるシスプラチン腎障害を排した神経芽腫化学療法(先端)

2015 - 2017 Roles of sulfated N-glycans in myelin

2015 - 2017 正常発達逸脱によるがん発生機構

2015 - 2017 沖縄県北部産島野菜の免疫調節機能及び抗腫瘍機能を活用した健康食品及び医薬品の開発・事業化

2015 - 2017 VRK1キナーゼ阻害剤による難治性神経芽腫の治療法開発(先端)

2015 - 2017 なぜ遺伝子変異なしでがんができるのか:その分子基盤解明と標的探索

2007 - 2017 癌に対するミッドカインRNAアプタマーの研究

2010 - 2016 Comprehensive Brain Science Network

2013 - 2016 難治性神経芽種の合成致死治療(先端)

2012 - 2015 Identification of the genes involved in the tumorigenesis and spontaneous regression in neuroblastoma model mice

2012 - 2015 Screening for the genes which shows synergistic phenotype with MYCN-With the aim of new molecular target of neuroblastoma

2012 - 2015 Enzymatic degradation of heparan sulfate subdomains that are accumulated in cerebral amyloid plaques

2012 - 2015 Target-cell specific siRNA delivery via collagen receptors on the cells

2011 - 2015 The establishment of the novel immunotherapy for neuroblastoma using transgenic mouse

2013 - 2015 がん自然退縮の制御機構解明

2013 - 2015 神経芽腫治療法開発へのモデル動物の応用

2011 - 2014 Elucidation of mechanisms of action of the growth factor midkine which is involved in inter-organ crosstalk regulating inflammation and blood pressure

2007 - 2012 疾患モデルブタの研究開発

2010 - 2012 Establishment of a new disease concept "the kidney and lung correlation through RAS in a renal damage"

2009 - 2011 Systemic siRNA delivery to prevent interferon-response in animals

2008 - 2010 Growth factor and extracellular matrix in neural reconstruction

2007 - 2008 Role of Basigin-VEGF/NO signal in the diabetic nephropathy

2007 - 2008 Therapeutic agent for occlusive peripheral vascular disease

2007 - 2008 A novel cancer therapy using type-I interferon, which is induced by siRNA or short single-stranded RNA in a nucleotide-specific manner

2006 - 2008 New Gene Therapy-Controlled Release of siRNA as to Midkine Inhibits the Intimal Hyperplasia in Vein Grafts

2006 - 2007 The role of glycosaminoglycan in neuronal injuries

2005 - 2006 The establishment of new animal models for diabetic nephropathy (DN) and the development of Midkine-targeted therapy against DN.

2005 - 2006 Midkine plays a protective role against cardiac remodeling

2005 - 2006 Analysis of the mechanism causing female infertility in mice deficient midkine and pleiotrophin.

2005 - 2006 Analysis of the function of the glycoprotein, basigin, in the process of male reproduction

2005 - 2006 神経と生殖器におけるオリゴマンノース認識レンチン、ベイシジンの役割

2005 - 2005 リンパ管新生因子VEGF-Cとその受容体VEGF-R3の発現抑制による癌転移抑止

2004 - 2005 Two intracellular traffics of a growth factor

2003 - 2005 The New Strategy of Gene Therapy for the Patients with Pheripheral Arterial Disease

2003 - 2004 Therapeutic Potential of Anti-Midkine Therapy in Progressive Renal Diseases

2003 - 2004 Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction

2003 - 2004 The Role of Midkine in the Pathogenesis of Rheumatoid Arthritis

2003 - 2004 Development of therapy for malignant tumors and inflammatory diseases employing midkine as a molecular target

2002 - 2003 Intracellular signaling and endocytosis of the growth factor midkine

2001 - 2002 Role of Midkine in Glomerular and Tubulointerstitial Injuries

2000 - 2002 Biological significance of N-acetylglucosamine 6-sulfation

2000 - 2000 ミッドカインによる細胞移動の分子的基盤

2000 - 2000 ミッドカインによる形態形成の分子機構

1999 - 2000 Action Mechanism of Basigin, a Membrane Glycoprotein Belonging to the Immunoglobulin Superfamily

1999 - 1999 発生におけるミッドカインの細胞内シグナルの解明

1998 - 1999 EFFECTS OF MIDKINE ON NEOINTIMA FORMATION IN A RESTENOSIS MODEL

1998 - 1999 Establishment of Ryudocan Null Mouse and ELISA for Blood Levels of Ryudocan

1998 - 1998 モデルマウスを用いた無精子症の遺伝子治療と精子生成過程の分子レベルでの解析

1998 - 1998 動脈硬化の発症病態に関わるHSPG・Ryudocanの機能解析

1998 - 1998 発生におけるミッドカインの作用機構

1998 - 1998 がん発生・進展に重要なミッドカインの組織保護能と細胞内シグナル伝達

1998 - 1998 細胞膜情報交換系の構造、機能解析と個体レベルでの役割

1997 - 1998 Application of midkine to diagnosis and treatment of tumors and growth of blood stem cells.

1997 - 1997 初期発生におけるヘパリン結合性成長因子ミッドカインの役割

1997 - 1997 がん進展におけるミッドカインの役割および変異型MKの機能解析

1996 - 1997 Growth factor midkine : Biological significance, action mechanism, tissue repairing activity and relationship with diseases.

1996 - 1996 ヘパリン結合性成長因子ミッドカインの標的組織の同定およびシグナル伝達機構の解明

1996 - 1996 がんの発生と進展におけるミッドカイン作用機構の解明

1995 - 1995 感覚神経栄養因子としてのミッドカイン;標的細胞および活性ドメインの同定

1995 - 1995 がん化およびがん進展におけるミッドカインの役割

1994 - 1995 Receptor structure and inhibition of midkine, a growth factor controled by retinoic acid

1994 - 1994 マウス初期発生におけるアポトーシスの役割およびそのサイトカインによる制御

Show all

Papers (316)：

Yuji Suzuki, Shoma Tsubota, Kenji Kadomatsu, Kazuma Sakamoto. Identification of APPB1 as a substrate for anaplastic lymphoma kinase. Journal of biochemistry. 2024
Shintaro Komatsu, Noritoshi Kato, Hiroki Kitai, Yoshio Funahashi, Yuhei Noda, Shoma Tsubota, Akihito Tanaka, Yuka Sato, Kayaho Maeda, Shoji Saito, et al. Detecting and exploring kidney-derived extracellular vesicles in plasma. Clinical and experimental nephrology. 2024. 28. 7. 617-628
Yusuke Matsui, Akira Togayachi, Kazuma Sakamoto, Kiyohiko Angata, Kenji Kadomatsu, Shoko Nishihara. Single-cell Glycogenomics Deciphers Links Between Altered Transcriptional Regulation and Aberrant Glycosylation in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2023
Lei Zhai, Anushree Balachandran, Rebecca Larkin, Janith A Seneviratne, Sylvia A Chung, Amit Lalwani, Shoma Tsubota, Dominik Beck, Kenji Kadomatsu, Anneleen Beckers, et al. Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma. International journal of molecular sciences. 2023. 24. 21
Jun Ouchida, Tomoya Ozaki, Naoki Segi, Yuji Suzuki, Shiro Imagama, Kenji Kadomatsu, Kazuma Sakamoto. Glypican-2 defines age-dependent axonal response to chondroitin sulfate. Experimental neurology. 2023. 366. 114444-114444

ｍore...

MISC (377)：

坂元一真, 伊藤定之, 尾崎智也, 門松健治. エノキサパリンはPTPRσを阻害することにより神経損傷後機能回復を促進する. 日本生化学会大会(Web). 2020. 93rd
坂元一真, 門松健治. Mechanisms of formation of dystrophic endballs by sulfated glycans. 生化学. 2020. 92. 2
門松健治, 坂元一真, 尾崎智也, GONG Yuanhao. 糖鎖を介した受容体型ホスファターゼと受容体型キナーゼのクロストークによる軸索再生制御. 日本生化学会大会(Web). 2020. 93rd
坂元一真, 坂元一真, GONG Yuanhao, 尾崎智也, 尾崎智也, 門松健治, 門松健治. Heparan sulfate promotes axonal regeneration via ALK. 日本糖質学会年会要旨集. 2020. 39th
坂元一真, OZAKI Tomoya, GONG Yuanhao, 門松健治. 硫酸化糖鎖によるオートファジーと神経軸索再生制御. 日本生化学会大会(Web). 2019. 92nd

ｍore...

Books (29)：

「神経回路再生ならびに小児がん神経芽腫の研究」
丸善プラネット 2022
細胞のメカニズムと神経疾患〜オートファジーと軸索、神経変性疾患〜
Clinical Neuroscience 39巻4号 pp384-387 2021
Human Glycome Project への世界と日本の動き〜本特集の序に代えて〜
生化学 2020
「糖鎖生物学」神経と糖鎖(I)-神経発生と再生
名古屋大学出版会 2020
Glycoscience: Basic Science to Applications〈1st ed. 2019〉 : Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG)
Springer 2019

ｍore...

Lectures and oral presentations (36)：

生命科学の未来:糖鎖がもたらす革新
(2022年度日本生化学会中国四国支部例会 2022)
生命科学の中のヒューマングライコームプロジェクト
(第40回日本糖質学会年会 2021)
ヒト糖鎖プロジェクトと医療
(第2回生体防御医学セミナー 2021)
基礎医学から産学官民連携まで〜老化との包括的な対峙
(第63回日本老年医学会 2021)
Chondroitin sulefate, heparan sulfate and PTP σ :Roles in axon regeneration and synaptogenesis
(3rd Australasian Glycoscience Symposium (3rd AGS) 2021)

ｍore...

Professional career (1)：

医学博士 (九州大学医研第830号) (九州大学)

Work history (18)：

2022/04 - 現在東海国立大学機構理事・名古屋大学副総長
2021/01 - 現在 iGCORE
2004/09 - 現在 Department of Biochemistry Nagoya University Graduate School of Medicine. Professor
2017/04 - 2022/03 Nagoya University Graduate School of Medicine
2012/03 - 2017/04 Nagoya University Graduate School of Medicine, Graduate School of Medicine

Show all

Committee career (15)：

2021/04 - 現在形態・細胞生物医科学分科会連携会員
2020/10 - 現在日本学術会議会員
2018/01 - 現在日本癌学会評議員
2018 - 現在自然科学研究機構生命創成探究センター運営委員運営委員
2015 - 現在 Canser Science Associate Editor

Show all

Awards (2)：

2001 - Flokert Belzer Award for distiguished research
1997 - 日本生化学会平成9年度日本生化学会奨励賞

Association Membership(s) (5)：

JCGG , 日本糖質学会 , Advances in Neuroblastoma Research Association (ANRA) , 日本癌学会 , 日本生化学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page