Nishijima Ken-ichi

ニシジマケンイチ | Nishijima Ken-ichi

Affiliation and department：
Job title：講師

Research field (2)： Radiology , Pharmaceuticals - analytical and physicochemistry

Research keywords (14)： PET , Thymidine Phosphorylase , 血管新生 , 血小板由来血管内皮細胞増殖因子 , [C-11]ホスゲン , 腫瘍イメージング , F-18標識合成 , 放射性医薬品 , 標識化反応 , 核医学診断 , 放射線 , SPECT , 放射薬品化学 , radiopharmaceutical chemistry

Research theme for competitive and other funds (24)：

2022 - 2027 多価効果と代謝性リンカーの融合による革新的核医学治療薬の開発
2023 - 2026 薬物送達システムとα線放出核種を組み合わせた革新的な白血病治療法の開発
2022 - 2025 血管新生因子PD-ECGFを標的としたAt-211標識治療用放射性薬剤の基礎検討
2020 - 2023 がん幹細胞をターゲットとしたα線放出核種を用いた革新的な白血病治療法の開発
2019 - 2022 Analyses of chromosomal abnormality in normal somatic cells induced by alpha-particle therapy

2019 - 2022 PD-ECGF targeted tumor treatment with new At-211 radiolabeled uracil derivatives

2015 - 2018 Vulnerability Assessment of Atherosclerosis by PET

2014 - 2018 Nuclear medicine imaging toward therapeutic strategy of atherosclerosis: Experimental research to establish EBM

2015 - 2017 A Challenge of radio-isotope therapy for atherosclerosis: Development of a radiopharmaceutical to suppress macrophage infiltration

2015 - 2017 Evaluation of arrhythmogenesis in patients with cardiac sarcoidosis using PET-MRI fusion images

2015 - 2016 がん悪性度診断ための新規PET用チミジンホスホリラーゼF18イメージング剤の開発

2014 - 2016 PD-ECDF-targeted tumor imaging: Development of production system for I-123 labeled compound

2011 - 2014 Development of new diagnosis approaches for detecting cardiovascular dysfunction in patients with respiratory disease using positron emission tomography

2011 - 2013 Molecular imaging in tumor proliferation and angiogenesis: Development of a early assessment tool for measuring the tumor response to treatment with molecular targeted drugs

2011 - 2013 Application of new generation PET to brain tumor treatment strategy

2011 - 2013 PD-ECGF-targeted tumor imaging with new F-18 radiolabeled uracil derivatives

2011 - 2012 Early andspecific detection of unstable atherosclerotic pl:aqTuiesssue factor imaging using pre-targeting systems

2011 - 2012 Reevaluation of cardiac neuronal function: Compari son with

2008 - 2010 PD-ECGF-targeted tumor imaging with new radiolabeled uracil derivatives

2007 - 2008 Assessment of coronary endothelial function using positron emission tomography

2006 - 2007 PD-ECGFを標的とした分子イメージング剤の開発

2005 - 2007 Development of PET radiopharmaceuticals for pyrimidine'nucleotide metabolic imaging

2004 - 2006 Fundamental Studies on the Development of New Diagnostic Radio Tracers Targeting Angiogenesis Factors

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Papers (87)：

伊藤浩, 茨木正信, 山國遼, 末永博紀, 菅原茂耕, 石井士朗, 福島賢慈, 久保均, 右近直之, 西嶋剣一, et al. O-15標識ガス定常吸入法を用いた脳循環代謝諸量の無採血定量法の開発理論とシミュレーション-. 核医学. 2022. 59. Suppl. S459-S459
Shigeru Yamaguchi, Kenji Hirata, Michinari Okamoto, Eku Shimosegawa, Jun Hatazawa, Ryuichi Hirayama, Naoki Kagawa, Haruhiko Kishima, Noboru Oriuchi, Masazumi Fujii, et al. Determination of brain tumor recurrence using 11 C-methionine positron emission tomography after radiotherapy. Cancer science. 2021. 112. 10. 4246-4256
Hiroshi Ito, Hitoshi Kubo, Kazuhiro Takahashi, Ken-Ichi Nishijima, Naoyuki Ukon, Ayaka Nemoto, Shigeyasu Sugawara, Ryo Yamakuni, Masanobu Ibaraki, Shiro Ishii. Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen. Annals of nuclear medicine. 2021. 35. 4. 421-428
Miho Aoki, Songji Zhao, Kazuhiro Takahashi, Kohshin Washiyama, Naoyuki Ukon, Chengbo Tan, Saki Shimoyama, Ken-ichi Nishijima, Kazuma Ogawa. Preliminary Evaluation of Astatine-211-Labeled Bombesin Derivatives for Targeted Alpha Therapy. Chemical and Pharmaceutical Bulletin. 2020. 68. 6. 538-545
Shiro Watanabe, Ken-Ichi Nishijima, Shozo Okamoto, Keiichi Magota, Kenji Hirata, Takuya Toyonaga, Tohru Shiga, Yuji Kuge, Nagara Tamaki. Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers. Annals of nuclear medicine. 2020. 34. 8. 595-599

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MISC (58)：

金澤崇史, 金澤崇史, 樵勝幸, 樵勝幸, 西嶋剣一, 山尾天翔, 志賀哲, 伊藤浩, 伊藤浩, 右近直之. Ga-68 PETのドーズキャリブレーターとPET装置の校正による定量性検討. 日本放射線技術学会総会学術大会予稿集. 2023. 79th
右近直之, ZHAO Songji, 鷲山幸信, 西嶋剣一, 織内昇, 下山彩希, 城寳大輝, 志賀哲, 高橋和弘, 伊藤浩. Comparison of ²¹¹At-MABG and ¹²³I-MIBG imaging for dosimetry in PC12 pheochromocytoma model mice. バイオメディカル分析科学シンポジウム講演要旨集. 2023. 35th
伊藤浩, 茨木正信, 山國遼, 末永博紀, 菅原茂耕, 石井士朗, 福島賢慈, 久保均, 右近直之, 西嶋剣一, et al. O-15標識ガス定常吸入法を用いた脳循環代謝諸量の無採血定量法の開発-理論とシミュレーション-. 核医学(Web). 2022. 59. Supplement
巽俊文, 山次健三, 杉山暁, ZHAO S., 粟生木美穂, 西嶋剣一, 右近直之, 下山彩希, GAO F., 城寶大輝, et al. Development of pre-targeting system using low immunogenic streptavidin mutants and 211-At-labeled bis-iminobiotin. 日本放射化学会討論会(Web). 2022. 66th
右近直之, 趙松吉, 鷲山幸信, 織内昇, 西嶋剣一, 下山彩希, 城寳大輝, 志賀哲, 高橋和弘, 伊藤浩, et al. 悪性褐色細胞腫PC12移植マウスにおける¹²³I-MIBGイメージングとex-vivo体内動態及び線量評価の比較. 核医学(Web). 2022. 59. Supplement

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Patents (13)：

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Lectures and oral presentations (40)：

PET/MRI装置およびO-15標識ガスを用いた脳血流量、脳血液量、脳酸素摂取率、脳酸素消費量の測定
(脳循環代謝 2019)
正常マウスにおける123I-MIBGと211At-MABGの体内動態の評価
(核医学 2019)
211At-MABG吸収線量評価におけるコンパニオン診断薬123I-MIBGの活用
(核医学 2019)
[211At]MABGの薄層クロマトグラフィー手順の探索
(核医学 2019)
O-15標識ガスおよび統合型PET/MRI装置を用いた脳循環代謝諸量の測定
(核医学 2019)

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Education (2)：

1997 - 1999 Health Sciences University of Hokkaido
1993 - 1997 Health Sciences University of Hokkaido Faculty of Pharmaceutical Sciences

Professional career (1)：

- (Health Sciences University of Hokkaido)

Work history (7)：

2018/03 - 現在 Fukushima Medical University
2016/04 - 2018/02 Hokkaido University Hokkaido University Hospital
2014/04 - 2016/03 Hokkaido University Central Institute of Isotope Science
2011/10 - 2014/03 Hokkaido University Graduate School of Medicine
2008/02 - 2011/09 Hokkaido University Graduate School of Medicine

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Awards (1)：

2005/12 - 日本薬学会北海道支部奨励賞臨床供給のためのPET用薬剤の高効率合成と製剤化に関する研究

Association Membership(s) (2)：

日本核医学会 , 日本薬学会

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