2018 - 2022 Clinical validation and metabolic endocrinological evaluation of novel mycotoxins control methods in herds
2018 - 2020 A mechanism of uterus for sensing sperm and inflammatory response toward development of new diluent of frozen bull semen
2017 - 2020 Immune tolerance to sperm and early embryo in cattle: Impact on immune cell function for fertility
2016 - 2020 Immune system of oviduct for very early pregnancy in dairy cattle: A crostalk between sperm/embryo and immune cells
2018 - 2019 Application to breeding technology utilizing the control of the newly discovered bovine uterine sperm sensing system
2019 - Research on tolerance activation of the intrauterine immune environment for improving the conception rate of bovine in vitro fertilized embryo transfer (ET)
2008 - 2010 Monitoring of natural zearalenone contamination in feeds of cattle herds, with special focus on the effect on reproductive efficacy.
2007 - 2009 Molecular physiology toward making non-regressing corpus luteum in the cow
2007 - 2008 An approach to improvement of fertility by elucidation of he genetic trait to affect on the liver function in high-producing dairy cow
2006 - 2007 Monitoring of naturally contaminated zearalenone concentrations in feeding environment of cattles.especially the effects for reproductive efficacy
2005 - 2007 New pathophysiological model for follicular development in dairy cow: Induction of follicular cyst using corpus luteum-absence model
2006 - 2006 北海道型高泌乳牛の健康科学:生殖と栄養の融合生理学に基づく現状と課題
2005 - 2006 血管シュミレーションシステムを用いた黄体機能解析モデルの構築
2005 - 2006 高泌乳牛の分娩直後に起こる排卵の栄養代謝的背景と卵巣機能回復促進効果
2004 - 2006 Molecular mechanisms for regulation of the corpus luteum function in dairy cows: control of life and death by angiogenesis and angiolysis, and vascular tonus
2004 - 2005 Study for mechanism of retained placenta in cattle
2004 - 2005 Roles of glucocorticoid in female reproduction
2003 - 2004 雌ウシの潜在能力を利用したホルモン処置を使わないダブル排卵モデルの確立
2003 - 2004 ウシ分娩時の子宮と卵巣内の局所調節機構の新しい生体複合モデルによる解析
2001 - 2002 ハイブリッド人工血管による黄体機能解析モデルの構築
2001 - 2002 Regulatory Mechanism of Glucocorticoid Action in the Bovine Ovary
2000 - 2002 Development of Technology for Regulating Reproductive Efficiency by Controlling Corpus Luteum Function in Cows
1999 - 2000 Local regulatory mechanisms of ovarian function by a cross-talk between vascular endothelial cells and ovarian cells : a mechanism of ovulation and corpus luteum formation.
1996 - 1996 反芻家畜の黄体退行現象の局所調節機構(生体微透析システムを中心とした解析)
1995 - 1995 生体微透析システムによる黄体分泌調節機構の解明(羊を実験モデルとして)
1994 - 1994 ミンククジラの繁殖生理に関する形態学的および内分泌学的基礎研究
1994 - 1994 生体微透析システムによる黄体分泌調節機構の解明(羊を実験モデルとして)
1993 - 1993 生体微透析システムによる黄体分泌調節機構の解明(羊を実験モデルとして)
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Papers (39)：
Ihshan Akthar, Yejin Kim, Takashi Umehara, Chihiro Kanno, Motoki Sasaki, Mohamed Ali Marey, Mohamed Samy Yousef, Shingo Haneda, Masayuki Shimada, Akio Miyamoto. Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle. Frontiers in Immunology. 2023. 14
Mohammad B Rashid, Mohamed A Marey, Kenji Fukuda, Shingo Haneda, Kazuya Kusama, Masayuki Shimada, Kazuhiko Imakawa, Akio Miyamoto. Intrauterine infusion of low levels of interferon-tau on day-8 post-estrus stimulates the bovine endometrium to secrete apolipoprotein-A1: A possible implication for early embryo tolerance. American journal of reproductive immunology (New York, N.Y. : 1989). 2022. 88. 3. e13592
Ahmed E Elweza, Mohamed A Marey, Ibrahim F Elesh, Mohammad A Zinnah, Ihshan Akhtar, Chihiro Kanno, Mitsuhiro Takagi, Akio Miyamoto. Zearalenone interferes with the sperm-triggered inflammation in the bovine uterus in vitro: Negative impact on sperm motility and survival. Reproductive toxicology (Elmsford, N.Y.). 2021
Kazuya Kusama, Mohammad B Rashid, Rasoul Kowsar, Mohamed A Marey, Anup K Talukder, Kentaro Nagaoka, Masayuki Shimada, Hasan Khatib, Kazuhiko Imakawa, Akio Miyamoto. Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions. Frontiers in genetics. 2021. 12. 676791-676791
Marey MA, Ezz MA, Akuthar I, Yousef MS, Imakawa K, Shimada M, Miyamoto A. Sensing sperm via maternal immune system: A potential mechanism for controlling microenvironment for fertility in the cow. J Anim Sci. 2020. 98. S88-S95
Marey MA, Yousef MS, Kowsar R, Hambruch N, Shimizu T, Pfarrer C, Miyamoto A. Local immune system in oviduct physiology and pathophysiology: Attack or tolerance?. Dom Anim Endocrinol. 2016. 56. S204-S211
Technology development that utilizes the immune activation to improve the conception rate of high-yielding cows and beef cattle
2020 - 現在
Development of fertilized embryo transfer (ET) technology
2020 - 現在
Development of artificial insemination technology using frozen semen
2020 - 現在
Education (4)：
- 1987 Tohoku University
- 1987 Tohoku University Graduate School, Division of Agriculture
- 1982 Obihiro University of Agriculture and Veterinary Medicine Faculty of Animal Husbandry
- 1982 Obihiro University of Agriculture and Veterinary Medicine Faculty of Animal Science
Professional career (1)：
Dr of Agriculture (Tohoku University)
Work history (6)：
2003 - Obihiro University of Agriculture & Veterinary Medicine,
1996 - 2002 Obihiro University of Agriculture and Veterinary Medicine
1993 - 1996 Obihiro University of Agriculture and Veterinary Medicine
1992 - 1993 Obihiro University of Agriculture and Veterinary Medicine
1990 - 1992 JSPS post doctoral fellow in foreign countries (Technical Univ. Munich, Institute of physiology)
1988 - 1990 A post doctoral fellow of DAAD (Technical Univ. Munich, Institute of physiology)
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Committee career (9)：
2007-2011 World Congress on Reproductive Biology International Organizing committee
2014 the 9th International Ruminant Reproduction Symposium Chair, Obihiro, JAPAN
2014 107th Annual meeting of Society for Reproduction and Development Chair, Obihiro, JAPAN
2018 10th International Ruminant Reproduction Symposium International Organizing committee, Fos de Iguasu, Brazil
2019 17th International Conference on Production Diseases in Farm Animals International Organizing committee, Bern, Switzerland
2020 19th International Congress on Animal Reproduction International Organizing committee, Bologna, Italy
Hokkaido Livestock Society Editorial Committee
Society for the Study of Reproduction Membership Committee
Japanese Society of Animal Science Councilor, Editorial Committee, Director
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Awards (1)：
1999 - SRD Research Award
Association Membership(s) (7)：
The Japanese Society of Veterinary Science
, American Society of Animal Science
, American Society of Dairy Science
, Hokkaido Society of Livestock Science
, Japanese Society of Animal Science
, Society for Reproduction and Development
, Society for the Study of Reproduction
