Shibasaki Hiromi

シバサキヒロミ | Shibasaki Hiromi

Affiliation and department：
Job title： Lecturer

Research field (3)： Metabolism and endocrinology , Pharmacology , Clinical pharmacy

Research keywords (6)：分析化学 , 薬物動態学 , 臨床薬学 , Analytical Chemistry , Biological Chemistry , Clinical Pharmacy

Research theme for competitive and other funds (19)：

2012 - 2015 The relationship between 11beta-hydroxysteroid dehydrogenase 2 enzyme activity and blood pressure in patients with renal disease
2004 - 2006 Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
2000 - 2002 Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
2000 - 2002 Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopes
1997 - 1999 Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

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Papers (91)：

鈴木優花, 樫本朱里, 横川彰朋, 降幡知巳, 柴崎浩美. 唾液中コルチゾールとその代謝物比を用いた非侵襲的CYP3A活性評価法の開発. TDM研究. 2024. 41. 2. 148-148
五十嵐俊二, 島崎隼人, 秋山遥香, 深江桃花, 降幡知巳, 柴崎浩美, 横川彰朋. 新規CYP1A2活性評価法の確立を目指した内因性メラトニン部分代謝クリアランスとカフェインクリアランスの比較. TDM研究. 2024. 41. 2. 185-185
Ryohei Hirano, Akitomo Yokokawa, Tomomi Furihata, Hiromi Shibasaki. Plasma 6β-hydroxycortisol to cortisol ratio as a less-invasive cytochrome P450 3A phenotyping method. British journal of clinical pharmacology. 2023
Aya Yamagata, Rena Adachi, Akitomo Yokokawa, Tomomi Furihata, Hiromi Shibasaki. Quantification of fluticasone propionate in human plasma by LC-MS/MS and its application in the pharmacokinetic study of nasal spray at clinical doses. Drug metabolism and pharmacokinetics. 2023. 54. 100541-100541
島崎隼人, 高野大輝, 尾川慎悟, 深江桃花, 秋山遥香, 五十嵐俊二, 降幡知巳, 柴崎浩美, 横川彰朋. LC-MS/MSを用いた血中メラトニンとカフェイン,パラキサンチン濃度の定量法の開発. JSBMS Letters. 2023. 48. Suppl. 62-62

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MISC (87)：

横川彰朋, 島崎隼人, 深江桃花, 五十嵐俊二, 秋山遥香, 降幡知巳, 柴崎浩美. Development of a Novel Method for Assessing CYP1A2 Activity Using Endogenous Melatonin Metabolism: Comparison with Caffeine Clearance to Establish an Assessment Method. 日本薬学会年会要旨集(Web). 2024. 144th
猪貝結実, 高田真希, 九原楓香, 横川彰朋, 降幡知巳, 柴崎浩美. Simultaneous determination of 6β-hydroxycortisol and cortisol in human nail by LC-MS/MS for evaluation of CYP3A activity. 日本薬学会年会要旨集(Web). 2023. 143rd
柴崎浩美, 横川彰朋, 降幡知巳. The effects of anticoagulants and storage conditions on plasma concentrations of 6β-hydroxycortisol and cortisol as determined by LC-MS/MS. JSBMS Letters. 2021. 46. Supplement
大木聖矢, 國松海佑, 尾川慎悟, 高野大輝, 降幡知巳, 柴崎浩美, 横川彰朋. Development of a LC-MS/MS-based quantification method for urinary endogenous 6-hydroxymelatonin to evaluate melatonin secretion. JSBMS Letters. 2021. 46. Supplement
横川彰朋, 北野彩, 田中大地, 東海, 簗田駿, 清水康平, 平野良平, 古田隆, 降幡知巳, 柴崎浩美. The effect of 11β-HSD2 activity on the prediction of plasma unbound cortisol concentration from saliva concentration. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)

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Patents (2)：

基材上に保持された乾燥血液を用いたヒトのCYP3A酵素活性の評価方法
ヒトにおけるCYP3A酵素活性の評価方法(フェノタイプ検査法)

Books (2)：

テーラーメイド医療 : 薬物治療の個別化
京都廣川書店 2017 ISBN:9784906992966
テーラーメイド医療-薬物治療の個別化
京都廣川書店 2010 ISBN:4901789619

Lectures and oral presentations (37)：

内因性メラトニン代謝を用いた新規CYP1A2活性評価法の開発: 評価法の確立に向けたカフェインクリアランスとの比較検討
(日本薬学会第144年会 2024)
血中6β-ヒドロキシコルチゾール/コルチゾール比による低侵襲CYP3A 活性評価と薬物相互作用評価への応用
(積水メディカル主催 Webinar 2024)
Using plasma 6β-hydroxycortisol/cortisol ratio for minimally invasive CYP3A phenotyping and its application to drug-drug interaction
(2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics 2023)
Ratio of 6β-hydroxycortisol to cortisol in human plasma and dried blood spots as a minimally invasive index of CYP3A activity
(2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics 2023)
安定同位体トレーサー法による体内動態解析を目指したGC-MSによるパルミチン酸定量法の確立
(第48回日本医用マススペクトル学会年会 2023)

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Professional career (1)：

Ph. D (Tokyo University of Pharmacy and Life Science)

Work history (1)：

2011/04 - 現在 Tokyo University of Pharmacy and Life Sciences Associate Professor

Committee career (1)：

2023/05 - 現在日本安定同位体・生体ガス医学応用学会評議員

Awards (1)：

2012/06 - 日本TDM学会第29回日本TDM学会・学術大会優秀演題賞

Association Membership(s) (12)：

日本安定同位体・生体ガス医学応用学会 , 日本TDM学会 , 日本臨床化学会 , 日本医用マススペクトル学会 , 日本薬物動態学会 , 日本内分泌学会 , International Isotope Society , 日本薬学会 , Japan Society for Therapeutic Drug Monitoring , Japanese Society for the Study of Xenobiotics , The Japan Endocrine Society , The Pharmaceutical Society of Japan

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