Taguchi Keiko

タグチケイコ | Taguchi Keiko

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： http://db.tohoku.ac.jp/whois/detail/c614d4b07ee6f608b86107caed7dd292.html , http://db.tohoku.ac.jp/whois/e_detail/c614d4b07ee6f608b86107caed7dd292.html

Research field (3)： Food sciences , Medical biochemistry , Pharmaceuticals - health and biochemistry

Research keywords (3)：食品化学 , 衛生薬学 , Biochemistry

Research theme for competitive and other funds (15)：

2022 - 2025 肝臓の組織構築におけるNrf2の新たな機能
2022 - 2025 硫黄生物学から紐解く膵癌難治化機構の解明と治療応用
2019 - 2024 Deciphering Molecular Basis for the Anti-Oxidative Stress Response and Application of the Basis for Disease Prevention and Therapy
2019 - 2022 Development of esophagus cancer acquired Nrf2 activation
2019 - 2022 Development of novel therapy for pancreatic cancer based on the regulation of oxidative stress responses

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Papers (92)：

Yu-Ichi Aoki, Keiko Taguchi, Hayato Anzawa, Junko Kawashima, Noriko Ishida, Akihito Otuki, Atsushi Hasegawa, Liam Baird, Takafumi Suzuki, Ikuko N Motoike, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. Journal of biochemistry. 2024
Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito. Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2. Communications Biology. 2023. 6. 1. 1060-1060
Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biology. 2023. 66. 102845-102845
Marta Anna Kowalik, Keiko Taguchi, Marina Serra, Andrea Caddeo, Elisabetta Puliga, Marina Bacci, Seizo Koshiba, Jin Inoue, Eiji Hishinuma, Andrea Morandi, et al. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. Hepatology (Baltimore, Md.). 2023. 79. 4. 829-843
Shimizu R, Hirano I, Hasegawa A, Suzuki M, Otsuki A, Taguchi K, Katsuoka F, Uruno A, Suzuki N, Yumoto A, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Commun Biol. 2023. 6. 1. 875-875

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MISC (33)：

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Books (6)：

酸化ストレスの医学改訂第2版
診断と治療社 2014
毒性の科学:分子・細胞から人間集団まで
東京大学出版会 2014
Protein modifications in pathogenic dysregulation of signaling
Springer 2014
実験医学増刊号
羊土社 2012
実験医学増刊号
羊土社 2012

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Lectures and oral presentations (72)：

Nrf2の活性制御破綻がもたらす肝病態
(第87回日本生化学会大会 2014)
Liver diseases caused by perturbation of Nrf2 regulation
(第73回日本癌学会学術総会 2014)
Two-step regulation of Nrf2 activity in the liver
(フォーラム2014衛生薬学・環境トキシコロジー 2014)
転写因子Nrf2の活性制御メカニズムと病態
(転写若手放射線生物学研究会勉強会 2014)
Molecular Mechanisms and Functions of Keap1-Nrf2 system
(2014 International Symposium and Annual Meeting of the KSABC (The Korean Society for Applied Biological Chemistry) 2014)

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Professional career (1)：

Ph.D. in Medicine (University of Tsukuba)

Work history (5)：

2023/06 - 現在 Tohoku Medical Megabank Organization, Tohoku University Visiting Associate Professor
2023/06 - 現在 Graduate School of Agricultural and Life Sciences, The University of Tokyo Laboratory of Food Chemistry, Department of Applied Biological Chemistry Associate Professor
2017/04 - 2020/03 Tohoku University Graduate School of Medicine Senior Assistant Professor
2008/01 - 2017/03 Tohoku University Graduate School of Medicine Assistant Professor
2006/04 - 2007/12 科学技術振興機構 JST-ERATO山本環境応答プロジェクト技術員・研究員

Committee career (6)：

2022/12 - 現在 The Japanese Society of Toxicology Executive board member
2022/07 - 現在 The Japanese Society of Toxicology ASIATOX
2021/10 - 現在 ASIATOX Councilor Councilor
2020/04 - 現在宮城県環境影響評価技術審査会
2016/04 - 2019/03 日本薬学会環境・衛生部会研究戦略委員会委員

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Awards (9)：

2020/01 - 東北大学医学部東北大学医学部奨学賞(金賞) Keap1-Nrf2システムによる生体機能制御機構の解明
2017/07 - The Japanese Scociety of Toxicology The JSOT Young Scientist Award
2016/07 - The Naito Foundation 41st Naito Conference Poster Award Nrf2 is a critical factor for hepatocellular adenoma in impaired autophagy
2015/12 - Japanese Biochemical Society Young Investigator Award
2013/09 - 倶進会・日本生化学会第10回柿内三郎記念奨励研究賞

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Association Membership(s) (6)：

Japan Scoety for Bioscience, Biotechnology, and Agrochemistry , Sociey of Toxicology , 日本生化学会(2009/09-) , 日本癌学会(2009/02-) , 日本毒性学会(2007/01-) , 日本薬学会(2004/02-)

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