Sakurai Takayuki

サクライタカユキ | Sakurai Takayuki

Affiliation and department：
Job title： Associate Professor

Research field (1)： Zoological sciences

Research keywords (4)： Transgenic animal , Developmental biology , Genome Editing , Developmental engineering

Research theme for competitive and other funds (35)：

2023 - 2027 癌・精巣特異的嗅覚受容体を介した癌転移機構の解明と臨床応用
2023 - 2023 信州医学振興会
2021 - 2023 受容体活性調節システムによる生体内恒常性制御機構の解明と創薬への展開
2018 - 2021 Development of a novel therapy for lifestyle-related diseases and chronic organ damage by targeting the homeostatic regulation within the body
2018 - 2021 Elucidation of the mechanism of action of the olfactory receptor involved in cancer-specific metabolism

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Papers (115)：

Yunlu Zhao, Takayuki Sakurai, Akiko Kamiyoshi, Megumu Tanaka, Yuka Ichikawa-Shindo, Hisaka Kawate, Yorishige Matsuda, Yan Zhang, Qianqian Guo, Peixuan Li, et al. Adrenomedullin 2/Intermedin Exerts Cardioprotective Effects by Regulating Cardiomyocyte Mitochondrial Function. Hypertension. 2025
Takayuki Sakurai, Norio Takei, Yangxuan Wei, Marina Hayashi, Akiko Kamiyoshi, Hisaka Kawate, Satoshi Watanabe, Masahiro Sato, Takayuki Shindo. Efficient genome editing of two-cell mouse embryos via modified CRISPR/Cas electroporation. Scientific Reports. 2024. 14. 1
Negishi K, Aizawa K, Shindo T, Suzuki T, Sakurai T, Saito Y, Miyakawa T, Tanokura M, Kataoka Y, Maeda M, et al. Author Correction: An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility. Scientific reports. 2024
Tomoki Kasahara, Megumu Tanaka, Yunlu Zhao, Akiko Kamiyoshi, Takayuki Sakurai, Yuka Ichikawa-Shindo, Hisaka Kawate, Yorishige Matsuda, Yan Zhang, Qianqian Guo, et al. Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS. Peptides. 2024. 171. 171118-171118
Shinji Kakihara, Yorishige Matsuda, Kazutaka Hirabayashi, Akira Imai, Yasuhiro Iesato, Takayuki Sakurai, Akiko Kamiyoshi, Megumu Tanaka, Yuka Ichikawa-Shindo, Hisaka Kawate, et al. Role of Adrenomedullin 2/Intermedin in the Pathogenesis of Neovascular Age-Related Macular Degeneration. Laboratory investigation; a journal of technical methods and pathology. 2023. 103. 4. 100038-100038

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MISC (84)：

田中愛, 桜井敬之, 神吉昭子, 新藤優佳, 河手久香, 柿原伸次, Zhao Yunlu, 松田順繁, Zhang Yan, Guo Qianqian, et al. Vascular Homeostatic Function of the AM-RAMP2 System and Its Application to the Regulation of Lymph Node Metastasis(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ22-2
田中愛, 桜井敬之, 神吉昭子, 市川優佳, 河手久香, グオ・チェンチェン, リ・ペイセン, 大西菜穂, 笠原智貴, 新藤隆行. AM-RAMP2系の血管恒常性制御を介したリンパ節転移抑制作用. 日本内分泌学会雑誌. 2023. 98. 5. 1571-1571
田中愛, 桜井敬之, 神吉昭子, 市川優佳, 河手久香, 柿原伸次, Zhao Yunlu, 松田順繁, Zhang Yan, Guo Qianqian, et al. アドレノメデュリン-RAMP2系による、高内皮細静脈を介したリンパ節転移の制御. 血管. 2023. 46. 1. 48-48
Zhao Yunlu, 桜井敬之, 神吉昭子, 市川優佳, 河手久香, 田中愛, 柿原伸次, 松田順繁, Zhang Yan, Guo Qianqian, et al. 圧負荷ストレスに対する内因性アドレノメデュリン2/インターメディンの心臓保護作用. 血管. 2023. 46. 1. 54-54
甲斐健佑, 田中愛, 桜井敬之, 神吉昭子, 市川優佳, 河手久香, 柿原伸次, Zhao Yunlu, 松田順繁, Zhang Yan, et al. 癌細胞のRAMP3欠損は、Meflin陽性の良性癌関連線維芽細胞を誘導し、腫瘍増殖を抑制する. 血管. 2023. 46. 1. 61-61

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Books (5)：

Microinjection: Methods and Protocols Methods in Molecular Biology
Springer Nature 2019
Results and Problems in Cell Differentiation 63
Springer 2017
細胞工学 35 1
2016
医学のあゆみ 223 13
医歯薬出版 2007
RNAi A GUIDE TO GENE SILENCING
メディカルサイエンスインターナショナル 2004

Work history (4)：

2019/04 - Associate Professor, Department of Life Innovation, Institute for Biomedical Sciences, Shinshu University
2008/02 - Associate Professor Grad School Med Shinshu Univ
2005/10 - 2008/01 Senior Assistant Professor Grad School Med Shinshu Univ
1999/12 - 2005/09 Assistant Professor Schooi of Med Tokai Unicersity

Association Membership(s) (4)：

The Japanese Society for Genome Editing , The Japanese Society for Regenerative Medicine , The Molecular Biology Society of Japan , Japanese Society of Developmental Biology

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