Rchr
J-GLOBAL ID:200901026845243856   Update date: Mar. 14, 2024

YAMASHITA Jun K.

ヤマシタ ジュン | YAMASHITA Jun K.
Affiliation and department:
Job title: Project Professor
Homepage URL  (1): https://www.u-tokyo.ac.jp/focus/ja/people/k0001_04592.html
Research field  (3): Cardiology ,  Medical biochemistry ,  Anatomy
Research keywords  (10): extracellular vesicles ,  血管 ,  心臓 ,  多能性幹細胞 ,  再生 ,  分化 ,  Cardiovascular development ,  ES(Embryonic Stem)cells ,  Regeneration ,  Differentiation
Research theme for competitive and other funds  (54):
  • 2020 - 2023 細胞機能検出プローブを用いた3次元組織の動態・機能イメージング技術の開発
  • 2020 - 2023 Trials to reconsitute stem cell system in the heart for cardiac regeneration
  • 2019 - 2022 Identification of molecular mechanisms of RNF213-related occlusive cerebrovascular diseases and development of new treatment strategies
  • 2017 - 2022 分化再生と生体恒常性を制御するエクソソームの新しい細胞同調機能の解明とナノ粒子による生体機能制御への応用
  • 2018 - 2021 Exploration of novel in vitro lethal arrhythmia models with 3D tissues from human iPS cells
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Papers (202):
  • Tomohiro Minakawa, Jun K. Yamashita. Versatile extracellular vesicle-mediated information transfer: intercellular synchronization of differentiation and of cellular phenotypes, and future perspectives. Inflammation and Regeneration. 2024. 44. 1
  • Daisuke Heima, Masafumi Takeda, Yasuhiko Tabata, Kenji Minatoya, Jun K Yamashita, Hidetoshi Masumoto. Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device. The Journal of thoracic and cardiovascular surgery. 2023
  • Tomohiro Minakawa, Jun K. Yamashita. Extracellular vesicles and microRNAs in the regulation of cardiomyocyte differentiation and proliferation. Archives of Biochemistry and Biophysics. 2023. 109791-109791
  • 川東 正英, 湊谷 謙司, 芦原 貴司, 山下 潤. Human iPS Cell-engineered Heart Tissue to Reproduce Ventricular Fibrillation in Vitro(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ27-3
  • Junko Yamane, Takumi Wada, Hironori Otsuki, Koji Inomata, Mutsumi Suzuki, Tomoka Hisaki, Shuichi Sekine, Hirokazu Kouzuki, Kenta Kobayashi, Hideko Sone, et al. StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells. iScience. 2022. 25. 7. 104538-104538
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MISC (237):
  • Regenerative medicine and stem cell biology in blood and lymphatic vessel development. 2017. 68. 4. 285-289
  • Takeshi Ikuno, Hidetoshi Masumoto, Kohei Yamamizu, Miki Yoshioka, Kenji Minakata, Tadashi Ikeda, Ryuzo Sakata, Jun K. Yamashita. Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017). PLOS ONE. 2017. 12. 4
  • K. Yamamizu, T. Ikuno, H. Takakubo, H. Masumoto, K. Minakata, Y. Tabata, J. K. Yamashita. Human iPS cell-engineered 3D-cardiovascular tissue by stacking sheets with gelatin hydrogel microspheres for cardiac regenerative medicine. EUROPEAN HEART JOURNAL. 2016. 37. 1211-1211
  • H. Masumoto, M. Ishigami, T. Aoki, F. Takai, T. Ikuno, M. Kawatoh, K. Minakata, T. Ikeda, R. Sakata, J. Yamashita. Cardiac tissue sheet including human iPS cell-derived cardiomyocytes and vascular cells restores impaired left ventricular systolic function of infarcted porcine hearts: a preclinical study. EUROPEAN HEART JOURNAL. 2015. 36. 608-609
  • Differentiation toward cardiovascular cell populations from human iPS cells. 2015. 252. 11. 1176-1180
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Education (4):
  • - 1998 Kyoto University
  • - 1998 Kyoto University Graduate School, Division of Medicine
  • - 1990 Kyoto University Faculty of Medicine
  • - 1990 Kyoto University Faculty of Medicine
Professional career (1):
  • Doctor of Medicine (Kyoto University)
Work history (6):
  • 2022/07 - 現在 東京大学大学院医学系研究科 細胞組織コミュニケーション講座 特任教授
  • 2012 - 2022 京都大学iPS細胞研究所 増殖分化機構研究部門 教授
  • 2007 - 2012 京都大学再生医科学研究所 幹細胞分化制御研究領域 准教授(独立)
  • 2003 - 2007 京都大学再生医科学研究所 幹細胞分化制御研究領域 助教授(独立)
  • 2002 - 2003 京都大学大学院医学研究科 分子遺伝学 助教授
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Awards (9):
  • 2018/08 - JST 日本ベンチャー学会会長賞
  • 2016/08 - 内閣府 産学連携功労者表彰・ 日本学術会議会長賞
  • 2010/03 - 日本心血管内分泌代謝学会 高峰譲吉研究奨励賞
  • 2009/03 - Circulation, American Heart Association Best Paper Award 2008, Basic Science, Circulation
  • 2002 - 成人血管病研究振興財団・岡本研究奨励賞
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Association Membership(s) (9):
日本高血圧学会 ,  日本内分泌学会 ,  日本動脈硬化学会 ,  日本循環器学会 ,  日本内科学会 ,  日本分子生物学会 ,  日本血管生物医学会 ,  日本炎症再生医学会 ,  日本再生医療学会
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