Rchr
J-GLOBAL ID:200901026886842918   Update date: Mar. 23, 2023

Yasui Hironobu

ヤスイ ヒロノブ | Yasui Hironobu
Affiliation and department:
Job title: Associate Professor
Homepage URL  (2): https://www.vetmed.hokudai.ac.jp/organization/radbiol/http://www.hokudai.ac.jp/radiois/kenkyu_top_eng.html
Research field  (4): Environmental effects of chemicals ,  Environmental effects of radiation ,  Veterinary medicine ,  Radiology
Research keywords  (7): Ferroptosis ,  Senescence ,  核医学 ,  イメージング ,  放射線生物学 ,  低酸素 ,  放射線腫瘍学
Research theme for competitive and other funds  (21):
  • 2022 - 2027 多価効果と代謝性リンカーの融合による革新的核医学治療薬の開発
  • 2022 - 2026 Oxygen and pH imaging of malignant tumors using electron paramagnetic resonance
  • 2022 - 2025 生体金属ホメオスタシスの破綻による細胞死誘導の時空間動態解析と放射線治療への展開
  • 2021 - 2025 PET imaging for cancer treatment inducing ferrotosis
  • 2020 - 2025 Targetting of cancer-specific metabolic system for senolytic therapy
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Papers (75):
  • Ririko Nakaoka, Kazuhiro Kato, Kumiko Yamamoto, Hironobu Yasui, Shingo Matsumoto, Igor A Kirilyuk, Valery V Khramtsov, Osamu Inanami, Hiroshi Hirata. Electron Paramagnetic Resonance Implemented with Multiple Harmonic Detections Successfully Maps Extracellular pH In Vivo. Analytical chemistry. 2023. 95. 8. 3940-3950
  • Soichiro Takamiya, Masahito Kawabori, Tsukasa Kitahashi, Kentaro Nakamura, Yuki Mizuno, Hironobu Yasui, Yuji Kuge, Aki Tanimori, Yasuyuki Takamatsu, Kohei Yuyama, et al. Intracerebral Transplantation of Mesenchymal Stromal Cell Compounded with Recombinant Peptide Scaffold against Chronic Intracerebral Hemorrhage Model. Stem cells international. 2022. 2022. 8521922-8521922
  • Tatsuya Kawai, Masayuki Matsuo, Yoichi Takakusagi, Keita Saito, Fuminori Hyodo, Nallathamby Devasahayam, Shingo Matsumoto, Shun Kishimoto, Hironobu Yasui, Kazutoshi Yamamoto, et al. Continuous monitoring of post-irradiation reoxygenation and cycling hypoxia using electron paramagnetic resonance imaging. NMR in biomedicine. 2022. e4783
  • Masaki Fujimoto, Ritsuko Higashiyama, Hironobu Yasui, Koya Yamashita, Osamu Inanami. Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis. Translational oncology. 2022. 21. 101431-101431
  • Tomoki Bo, Hironobu Yasui, Tohru Shiga, Yuki Shibata, Masaki Fujimoto, Motofumi Suzuki, Kei Higashikawa, Naoki Miyamoto, Osamu Inanami, Yuji Kuge. Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human cancer xenograft models. European journal of nuclear medicine and molecular imaging. 2022. 49. 3. 821-833
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MISC (28):
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Patents (1):
  • 陽子線治療用増感剤および陽子線治療方法
Books (4):
  • 放射線生物学
    近代出版 2015
  • 酸化ストレスの医学 改訂第二版
    2014
  • 小動物の実践歯科学
    緑書房 2013
  • 酸化ストレスの医学 第一版
    診断と治療社 2008
Lectures and oral presentations  (167):
  • EPR implemented with multiple harmonic detection successfully maps extracellular pH n vivo
    (12th International Workshop on EPR in Biology and Medicine 2022)
  • レドックスイメージングを目的とした[64Cu][CuI(BCS)2]+の合成とROSとの反応性評価
    (第5回日本核医学会分科会放射性薬品科学研究会/第21回放射性医薬品・画像診断薬研究会 2022)
  • 新しい可搬型EPRI装置を用いた腫瘍内レドックスイメージングによる放射線治療応答の非侵襲的解析
    (日本放射線影響学会第65回大会 2022)
  • X線照射および抗がん剤によって生じるがん老化細胞に対するYM155のセノリシス作用に関する研究
    (日本放射線影響学会第65回大会 2022)
  • Redox-based imaging analysis with a novel portable EPRI device for tumor response to radiation
    (2022)
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Education (3):
  • 2004 - 2008 Hokkaido University
  • 1998 - 2004 Hokkaido University School of Veterinary Medicine Veterinary Medicine
  • 1997 - 1998 Osaka University School of Science Department of Physics
Professional career (1):
  • Doctor of Philosophy (Hokkaido University)
Work history (7):
  • 2018/07 - 現在 Hokkaido University Laboratory of Radiation Biology Department of Applied Veterinary Sciences Graduate School of Veterinary Medicine Associate Professor
  • 2016/04 - 2018/06 Hokkaido University Central Institute of Isotope Science Associate Professor
  • 2009/09 - 2016/03 Hokkaido University Laboratory of Radiation Biology Department of Environmental Veterinary Sciences Graduate School of Veterinary Medicine Assistant Professor
  • 2009/09 - 2016/03 Graduate School of Veterinary Medicine, Hokkaido University Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Assistant Professor
  • 2012/03 - 2012/08 National Cancer Institute / National Institutes of Health Visiting Fellow
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Committee career (9):
  • 2022/05 - 現在 日本酸化ストレス学会 代議員
  • 2020/06 - 現在 日本放射線影響学会 学術評議員
  • 2020/04 - 現在 日本アイソトープ協会 放射線安全取扱部会 企画専門委員
  • 2020/02 - 現在 日本酸化ストレス学会 若手の会 会長
  • 2018/06 - 現在 泊発電所環境保全監視協議会委員
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Awards (7):
  • 2021/06 - 日本放射線腫瘍学会生物部会 生物部会賞
  • 2017/10 - 日本放射線影響学会 日本放射線影響学会奨励賞
  • 2015/11 - 電子スピンサイエンス学会 電子スピンサイエンス学会奨励賞
  • 2015/09 - 日本放射線影響学会 放射線ワークショップ優秀発表賞
  • 2014/03 - Informa Healthcare Young Investigator Award 2014
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Association Membership(s) (9):
日本分子イメージング学会 ,  THE JAPANESE CANCER ASSOCIATION ,  INTERNATIONAL ASSOCIATION FOR THE SENSITIZATION OF CANCER TREATMENT ,  THE SOCIETY OF ELECTRON SPIN SCIENCE AND TECHNOLOGY ,  SOCIETY FOR FREE RADICAL RESEARCH JAPAN ,  THE JAPAN RADIATION RESEARCH SOCIETY ,  THE JAPANESE SOCIETY OF VETERINARY SCIENCE ,  Japan Radioisotope Association ,  Japanese Society for Radiation Oncology
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