Research field (3)：
Marine/Aquatic life sciences
, Cell biology
, Functional biochemistry
Research keywords (5)：
転移
, 耐性
, ヌクレオシド
, Photodynamic therapy
, cancer metastasis
Research theme for competitive and other funds (19)：
2021 - 2024 多機能性チロシンキナーゼ阻害薬の創出とがん光線力学療法への応用研究
2020 - 2023 消化器癌におけるNa+/H+交換輸送体5の機能解析と特異的阻害薬の開発
2016 - 2019 大腸癌における Na+/H+交換輸送体阻害による新規抗癌治療法の開発
2014 - 2017 Development of radiosensitizers based on antitumor/molecular targeted drugs modified by acetylglucose
2014 - 2017 膜輸送系を標的とする光線力学的治療の効果増強剤の新薬シーズ開発
2013 - 2015 Analysis of a novel small-molecule compound inducing the degradation of a cisplatin resistance-related factor ERCC1
2011 - 2014 細胞膜輸送系の機能修飾に基づく光線力学的治療の効果増強法の基礎開発
2011 - 2014 腹膜偽粘液腫の本邦における発生頻度・病態の解明・治療法の開発
2006 - 2008 癌の腹膜播種原因遺伝子の同定と新しい分子標的治療
2005 - 2006 Predictive Markers of chemosensitivity to antitumor nucleosides in solid cancer
2006 - Novel application of photodynamic diagnosis and therapy for cancer
2001 - 2003 リンパ管増殖とリンパ節転移の分子機構の解明と臨床応用に関する研究
2001 - 2001 多機能性血管新生阻害剤の開発
2001 - Antitumor mechanisms of nucleoside antimetabolites
1999 - 2000 ヒト胃癌の腹膜播種モデルをもちいた新治療法の開発
1997 - 1998 Estashment of peritoneal dissumination model and clinical application.
1990 - Antitumor mechanisms of novel nucleosides
Development of effective diagnosis and therapy for metastatic cancer
Development of angiogenesis inhibitors as an anticancer drug
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Papers (145)：
Yusei Shinohara, Yuki Komiya, Kashin Morimoto, Yoshio Endo, Minoru Terashima, Takeshi Suzuki, Takahisa Takino, Itasu Ninomiya, Hisatsugu Yamada, Yoshihiro Uto. Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound. Bioorganic & medicinal chemistry. 2024. 99. 117603-117603
Yutaka Yonemura, Haruaki Ishibashi, Akiyoshi Mizumoto, Gorou Tukiyama, Yang Liu, Satoshi Wakama, Shouzou Sako, Nobuyuki Takao, Toshiyuki Kitai, Kanji Katayama, et al. The Development of Peritoneal Metastasis from Gastric Cancer and Rationale of Treatment According to the Mechanism. Journal of clinical medicine. 2022. 11. 2
Yoshio Endo, Yoshihiro Uto, Yusei Shinohara, Chiaki Abe, Tohru Obata, Yutaka Yonemura, Shun-ichiro Ogura. An iron metabolism-targeting drug with antitumor activity enhances the effect of 5-ALA-based photodynamic therapy. CANCER SCIENCE. 2021. 112. 917-917
Yusei Shinohara, Itasu Ninomiya, Yoshio Endo, Takahisa Takino, Yoshihiro Uto. Development of a Novel Amiloride Derivative as a Na plus /H plus exchanger 5 selective inhibitor. CANCER SCIENCE. 2021. 112. 912-912
Hirari Yamahana, Takahisa Takino, Yoshio Endo, Takeshi Suzuki, Yoshihiro Uto. Development of a Novel Celecoxib Derivative UTX-121 as an Antimetastatic Agent. CANCER SCIENCE. 2021. 112. 695-695
