YAMAGISHI Toshiyuki

ヤマギシトシユキ | YAMAGISHI Toshiyuki

Affiliation and department：
Job title： Professor

Research field (3)： Cell biology , Anatomy , Developmental biology

Research keywords (5)：心臓発生 , 器官形成 , 心臓 , 循環器 , 発生生物学

Research theme for competitive and other funds (29)：

2022 - 2025 ゼブラフィッシュ胚心臓における刺激伝導系細胞の可視化とその発生過程の発現情報収集
2023 - 2024 胚心臓の心内膜床形成におけるCXCL12-CXCR7シグナルの役割
2023 - 2024 Ad4BP-BAC-EGFPトランスジェニックマウスにおける脾臓杆状内皮細胞の発生生物学的解析
2022 - 2023 胚心臓の心内膜床形成過程におけるCXCL12、CXCR7の局在とその役割
2021 - 2022 胚心内膜床形成でおこる内皮-間葉形質転換を誘導するGDF2とBMP2の作用機構

2020 - 2021 心内膜床形成過程の内皮-間葉形質転換における転写因子sox9とslugの協調作用機構の解明

2015 - 2017 心臓発生過程で起こる心外膜前駆細胞分化でのレチノイン酸の役割

2012 - 2014 胚心臓の心内膜床でおこる上皮-間葉形質転換での分泌因子Rspo3の役割

2009 - 2011 Roles of transcription factors during endothelial-mesenchymal transformation in the developing chick heart

2006 - 2008 A role of wnt and BMP during endocardial cushion tissue formation

2007 - 2007 先天性心疾患発症機構の解明:心内膜床形成でのsox転写因子群の役割

2004 - 2006 胚心臓発生過程でおこる心内膜床領域決定での転写因子TBX20の役割

2002 - 2006 心臓弁や中隔原基の心内膜床形成に関わるH8D8蛋白の遺伝子クローニングと機能解析

2005 - 2005 先天性心奇形発生機序の解明:心内膜床形成にかかわる因子の網羅的な解析

2003 - 2005 Role of TBX20 in endocardial cushion formation during chick heart development

2003 - 2004 Identification of a regulatory region which is involved in Sox-2 expression in embryonic and neural stem cells and its molecular basis

2003 - 2004 Cloning and characteristics of the novel H8D8 protein regulating valvuloseptal endocardial cushion tissue formation

2003 - 2003 心臓形態形成の分子機構の解明:とくに心内膜床形成過程で起こる内皮-間葉形質転換の分子機構について

2001 - 2002 心内膜床形成過程における上皮ー間葉系相互作用でのホメオボックス遺伝子Msx1の役割

1998 - 2001 Purification and cloning of novel inductive factors that regulate endothelial-mesenchymal transformation in endocardial cushion tissue formation

1999 - 2000 心内膜床形成での心内皮細胞の形質転換におけるBMPとTGFβの協調作用の分子機構

1997 - 1998 ニワトリ胚に発現する骨形成因子(BMP)遺伝子の特異抗体の作製と蛋白質の発現

1997 - 1997 心臓弁原基である心内膜床形成を誘導する生理活性物質の精製と遺伝子クローニング

1997 - 1997 心内膜床形成におけるBMP2のTGFβ3活性機構の解明

1997 - 1997 心臓形態形成において内皮細胞を間葉細胞に分化誘導する生理活性物質の分離精製と遺伝子クローニング

1996 - 1996 心内膜床における骨形成因子(BMP)の制御機構

1996 - 1996 ニワトリ胚に発現する新しい骨形成因子(BMP)遺伝子のクローニング

1992 - 1994 CELLULAR DIFFERENTIATION OF HEART AND VESSEL

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Papers (54)：

Toshiyuki Yamagishi, Mayu Narematsu, Yuji Nakajima. Msx1 upregulates p27 expression to control cellular proliferation during valvuloseptal endocardial cushion formation in the chick embryonic heart. The anatomical record. 2021. 304. 8. 1732-1744
Mayu Narematsu, Tatsuya Kamimura, Toshiyuki Yamagishi, Yuji Nakajima. Hypoxia-induced downregulation of Sema3a and CXCL12/CXCR4 regulate the formation of the coronary artery stem at the proper site. J Mol Cell Cardiol . 2020. 147. 62-73
Seiichi Kimura, Hiromu Amatani, Hikaru Nakai, Ren Miyauchi, Tomohito Nagaoka, Mikiko Abe, Masatake Kai, Toshiyuki Yamagishi, Yuji Nakajima. A novel case of multiple variations in the brachial plexus with the middle trunk originating from the C7 and C8. Anat Sci Int . 2020. 95. 4. 559-563
Tatsuya Kamimura, Toshiyuki Yamagishi, Yuji Nakajima. Avian coronary endothelium is a mosaic of sinus venosus- and ventricle-derived endothelial cells in a region-specific manner. Development Growth and Differentiation. 2018. 60. 2. 97-111
Mayu Narematsu, Tatsuya Kamimura, Toshiyuki Yamagishi, Mitsuru Fukui, Yuji Nakajima. Impaired Development of Left Anterior Heart Field by Ectopic Retinoic Acid Causes Transposition of the Great Arteries. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2015. 4. 5

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MISC (18)：

Tatsuya Kamimura, Toshiyuki Yamagishi, Yuji Nakajima. Heterogeneous origin of coronary endothelial cells in avian embryonic heart. MECHANISMS OF DEVELOPMENT. 2017. 145. S148-S149
Yamagishi Toshiyuki. Education Plaza. OCU journal of higher education studies. 2014. 11. 2. 97-98
Yanagawa Nariaki, Toshiyuki Yamagishi, Yuji Nakajima. Nodal signal is required for morphogenetic movements of epiblast cells in pre-streak chick blastoderm. DEVELOPMENTAL BIOLOGY. 2010. 344. 1. 440-440
Toshiyuki Yamagishi, Yuji Nakajima, Katsumi Ando, Masahide Sakabe, Hiroaki Nakamura. Expression patterns of sox9 gene during chick heart development. DEVELOPMENTAL BIOLOGY. 2008. 319. 2. 604-604
NAKAJIMA Yuji, ANDO Katsumi, YAMAGISHI Toshiyuki. Developmental biology of the heart : molecular understanding morphogenesis, malformations and regenerative medicine. 日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine. 2006. 13. 2. 115-123

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Books (18)：

Induction of smooth muscle α-actin positive heart mesoderm is regulated by combined Nodal and FGF8 function in avian pregastrula epiblast
IREIMS 2007
,Rho kinase (ROCK) in valvuloseptal endocardial cushion tissue formation
IREIMS 2007
Induction of smooth muscle α-actin positive heart mesoderm is regulated by combined Nodal and FGF8 function in avian pregastrula epiblast
IREIMS 2007
Rho kinase (ROCK) in valvuloseptal endocardial cushion tissue formation
IREIMS 2007
Development of proximal coronary artery in quail embryonic heart. In Cardiovascular development and congenital malformations: Molecular and genetic mechanisms
Blackwell Futura 2005

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Lectures and oral presentations (8)：

埼玉医科大学保健医療学部臨床検査学科における高校-大学間の学修方法のギャップ解消に向けた取り組み
(第17回日本臨床検査教育学会学術大会 2023)
Localization of <I>Cxcl12</I> mRNA during valvuloseptal endocardial cushion tissue formation in the chick embryonic heart
(2022)
胚心臓の心内膜床形成過程におけるMsx1による細胞増殖の制御
(第60回日本先天異常学会学術集会 2020)
Hypoxia-induced downregulation of Sema3a provides a template for endothelial strands for coronary artery stems and ostia
(Society for Developmental Biology 79th Annual Meeting 2020)
心臓弁や心臓中隔原基である心内膜床の形成機構
(2017)

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Professional career (1)：

博士 (埼玉医科大学)

Work history (2)：

2009/04 - 現在 Osaka City University Graduate School of Medicine
1995 - 2009 Saitama Medical University Faculty of Medicine, Anatomy

Committee career (6)：

2013 - 現在 THE JAPANESE TERATOLOGY SOCIETY
2013 - 現在日本先天異常学会日本先天異常学会
2011/01 - 2025/12 日本先天異常学会日本先天異常学会
2013/01 - 2024/12 日本先天異常学会日本先天異常学会学会誌 Congenital Anomalies 編集部
2011/01 - 2020/12 THE JAPANESE TERATOLOGY SOCIETY

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Association Membership(s) (5)：

日本臨床検査学教育学会 , アメリカ細胞生物学会 , アメリカ発生生物学会 , 日本解剖学会 , THE JAPANESE TERATOLOGY SOCIETY

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