Matsuura Yoshiyuki

Affiliation and department：
Job title： Associate professor

Research field (6)： Pharmaceuticals - analytical and physicochemistry , Tumor biology , Cell biology , Biophysics , Functional biochemistry , Structural biochemistry

Research theme for competitive and other funds (16)：

2022 - 2024 がんシグナル分子PKM2の核移行制御機構の構造基盤
2019 - 2021 がんの発症と進展に寄与するシグナル分子の核移行メカニズムの構造基盤
2016 - 2018 発がんに寄与する非受容体型チロシンキナーゼFerの活性化メカニズムの構造基盤
2017 - Src Family Kinaseのがんシグナルに対する新規阻害剤の探索
2017 - 白血病病因因子Nup98融合タンパク質の作用機序に関する構造生物学研究

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Papers (40)：

Yoshiyuki Matsuura. Defective recognition of a nonclassical nuclear localization signal in neurodevelopmental disorders. Structure. 2023. 31. 891-892
Yoshiyuki Matsuura, Kazuya Miyawaki. Structures of importin-α bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1α. Biochemical and Biophysical Research Communications. 2023. 652. 1-5
Yoshiyuki Matsuura. Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal. Data in Brief. 2023. 47. 108988-108988
Yoshiyuki Matsuura. High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase. Protein Science. 2019. 28. 2011-2019
Yoshiyuki Matsuura. Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha. Biochemical and Biophysical Research Communications. 2019. 510. 236-241

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MISC (4)：

松浦能行. 蛋白質複合体結晶構造が明らかにした蛋白質相互作用の多様性,巧妙性--核外輸送複合体の場合 (特集・構造生物学の現在と今後の展開). 生体の科学. 2005. 56. 6. 564-570,図巻頭2
松浦能行. 蛋白質核外輸送複合体のX線結晶構造解析. 蛋白質核酸酵素. 2005. 50. 5. 420-426
Y Matsuura, M Stewart. Structural basis for the nuclear export of Kap60p by Cse1p and RanGTP. BIOPHYSICAL JOURNAL. 2005. 88. 1. 185A-185A
Y Matsuura, M Stewart. Structural basis for the nuclear export of Kap60p by Cse1p : RanGTP. MOLECULAR BIOLOGY OF THE CELL. 2004. 15. 205A-205A

Lectures and oral presentations (4)：

核輸送の構造生物学
(理研セミナー 2016)
Structures and assembly/disassembly kinetics of the Ran-dependent nuclear export complexes
(2015)
CRM1核外輸送複合体の形成と解体の構造基盤
(日本分子生物学会年会 2013)
核外輸送複合体の結晶構造
(日本蛋白質科学会年会 2005)

Education (2)：

1995 - 2000 The University of Tokyo Graduate School of Science Department of Physics
1991 - 1995 The University of Tokyo Faculty of Science Department of Physics

Professional career (1)：

博士(理学) (東京大学)

Work history (8)：

2021/04 - 現在 International University of Health and Welfare School of Pharmacy Department of Pharmaceutical Sciences Professor
2020/04 - 2021/03 名古屋大学大学院理学研究科生命理学専攻准教授
2007/12 - 2020/03 Nagoya University Graduate School of Science Structural Biology Research Center Associate professor
2007/04/01 - 2007/11/30 Nagoya University Graduate School of Science Structural Biology Research Center Assistant Professor
2007/02/01 - 2007/03/31 Nagoya University Graduate School of Science Structural Biology Research Center Assistant

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Awards (1)：

2005/10 - Max Perutz Prize

Association Membership(s) (5)：

Japanese Society for the Control of Influenza , THE JAPANESE SOCIETY FOR VIROLOGY , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE BIOCHEMICAL SOCIETY , 日本薬学会

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