Tetsuji Miura

• 2021 - 2024 Intracellular signal transduction regulating necroptosis of cardiomyocytes
• 2018 - 2021 Cross-talk of cardiomyocyte necroptosis and autophagy in heart failure
• 2017 - 2020 Development of novel therapeutic approach for diabetic cardiomyopathy by modification of AMP deaminase activity.
• 2017 - Composition and function of mitochondrial protein kinase system in cardiomyocytes
• 2014 - 2017 Novel therapeutic approach for heart failure by suppression of mitochondrial translocation of GSK-3beta
2014 - 2017 Role of mitochondrial permeability transition in necroptosis of the cardiomyocyte
2013 - 2017 Establishment of classification and regression tree model for assessing of a risk for future occurence of life-style related disease using a community-based cohort data.
2011 - 2013 Novel therapeutic approach for heart failure by promoting nuclear translocation of SIRT1, a protein deacetylase
2011 - 2013 Protein kinases regulating the mitochondrial permeability transition pore
2008 - 2010 Clarification of mechanisms to regulate the activity of protein deacetylase SIRT1 and its therapeutic application in heart failure
2008 - 2010 Role of connexin-43 in protective signaling incardiomyocyte
2006 - 2007 Roles of connexin-43 in cardiomyocyte tolerance against ischemic injury
2004 - 2005 Intracellular Signaling Mechanisms Regulating Functions and Expression of the Gap Junction in Ischemic Myocardium
2001 - 2002 Modification of gap junctions during myocardial ischemia and its significance in myocardial necrosis
1996 - 1998 Suppression of ischemic myocardial injury by heat stress proteins
1992 - 1993 Mechanism of preconditioning against myocardial infarction
1988 - 1988 虚血心筋再灌流障害における活性酸素(O_2・-)の役割

• Masaki Shimizu, Wataru Ohwada, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Toshifumi Ogawa, Arata Osanami, Yuki Toda, Hiroshi Nagahama, Masaya Tanno, et al. Contribution of MLKL to the development of doxorubicin-induced cardiomyopathy and its amelioration by rapamycin. Journal of pharmacological sciences. 2024. 156. 1. 9-18
• Tetsuji Miura, Hidemichi Kouzu, Masaya Tanno, Yuki Tatekoshi, Atsushi Kuno. Role of AMP deaminase in diabetic cardiomyopathy. Molecular and Cellular Biochemistry. 2024
• Keisuke Oyatani, Masayuki Koyama, Nobuaki Himuro, Tetsuji Miura, Hirofumi Ohnishi. Characterization of prehospital time delay in primary percutaneous coronary intervention for acute myocardial infarction: analysis of geographical infrastructure-dependent and -independent components. International journal of health geographics. 2023. 22. 1. 7-7
• 小川 俊史, 神津 英至, 長南 新太, 清水 将輝, 戸田 悠貴, 大和田 渉, 佐藤 達也, 矢野 俊之, 久野 篤史, 丹野 雅也, et al. BCKDH活性のダウンレギュレーションとAMPデアミナーゼとのアンカップリングが2型糖尿病性心臓における基質柔軟性の欠如を引き起こす(Downregulation of BCKDH Activity and Uncoupling from AMP Deaminase Underlie Substrate Inflexibility in Type 2 Diabetic Hearts). 日本循環器学会学術集会抄録集. 2023. 87回. OJ03-2
• 小川 俊史, 神津 英至, 長南 新太, 清水 将輝, 戸田 悠貴, 大和田 渉, 佐藤 達也, 矢野 俊之, 久野 篤史, 丹野 雅也, et al. Downregulation of BCKDH Activity and Uncoupling from AMP Deaminase Underlie Substrate Inflexibility in Type 2 Diabetic Hearts(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ03-2

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• Arata Osanami, Masaya Tanno, Atsushi Kuno, Hidemichi Kouzu, Toshiyuki Yano, Tatsuya Sato, Tetsuji Miura, Toshifumi Ogawa. AMP Deaminase in Mitochondria-Associated ER Membranes Contributes to Reduction of the Threshold for Mitochondrial Permeability Transition in Type 2 Diabetic Hearts. CIRCULATION. 2021. 144
• OGAWA Toshifumi, KOUZU Hidemichi, OSANAMI Arata, TAKEKOSHI Yuki, MIZUNO Masashi, KUNO Atsushi, FUJITA Yugo, INO Shoya, SHIMIZU Masaki, OHWADA Wataru, et al. Novel role of AMP deaminase in cardiac branched-chain amino acid metabolism: A potential therapeutic target for diabetic cardiomyopathy. 日本心不全学会学術集会プログラム・抄録集. 2021. 25th
• 丹野雅也, 神津英至, 三浦哲嗣. 糖尿病性心筋症の病態・治療の現状とこれから. 糖尿病学の進歩. 2021. 55th
• 小山 雅之, 樋室 伸顕, 佐藤 琢真, 簑島 暁帆, 竹内 利治, 橋本 暁佳, 齋藤 重幸, 三浦 哲嗣, 寳金 清博, 大西 浩文. 地域連携クリティカルパスが適用された急性心筋梗塞患者における予後規定要因の検討. 日本循環器病予防学会誌. 2020. 55. 3. 224-224
• 高橋聖子, 田中希尚, 古橋眞人, 長南新太, 小山雅之, 後町結, 塙なぎさ, 茂庭仁人, 大西浩文, 三浦哲嗣. Fatty liver indexはCKD発症と関連する. 日本腎臓学会誌(Web). 2020. 62. 4

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• - 1980 Sapporo Medical University School of Medicine

• Doctor of Philosophy (Medical Science)

• 2019/12 - 北海道科学技術賞
• 2017/05 - International Society for Heart Research Janice Peffer Lecture Award
• 2012 - 北海道知事賞
• 2012 - 北海道医師会賞

THE JAPAN DIABETES SOCIETY ,  JAPANESE SOCIETY OF NEPHROLOGY ,  日本循環制御医学会(理事) ,  国際心臓研究学会日本部会(理事) ,  日本内科学会(評議員) ,  日本心電学会 ,  日本心不全学会(評議員) ,  ヨーロッパ心臓病学会 (Fellow) ,  米国心臓病学会 (Fellow) ,  日本循環器学会(社員) ,  米国心臓協会 (Fellow) ,  International Society for Heart Research ,  Japanese Society of Internal Medicine ,  American Physiological Society ,  Japanese Society of Electrocardiology ,  Japanese Heart Failure Society ,  European Cogress of Cardiology ,  American College of Cardiology ,  Japanese Circulation Society ,  American Heart Association