HIDEFUMI MAKABE

マカベヒデフミ | HIDEFUMI MAKABE

Affiliation and department：
Job title： Professor

Research field (1)： Bioorganic chemistry

Research theme for competitive and other funds (13)：

2023 - 2026 Synthesis of proanthocyanidins which posess pyrogaloll moiety and elucidation of mechanissm of action for anti-tumor activity
2022 - 2025 プロシアニジンガレートによるTLR7制御メカニズムの解明と皮膚炎予防効果の検証
2019 - 2022 Inhibitory effect of procyanidins on chronic inflammation through immune-metabolic regulation
2018 - 2021 Synthetic Studies on Natural Products
2015 - 2018 Enzymatic synthesis of novel rutinoside and its neuroprotective properties

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Papers (105)：

Hana Saito, Yoriko Takahashi, Atsushi Kawamura, Hidefumi Makabe. Synthesis of prodelphinidin B2 3,3′′-digallate using AgOTf-mediated self-condensation. Results in Chemistry. 2024. 12. 101902-101902
Tomoya Takao, Atsushi Kawamura, Hidefumi Makabe. First Total Synthesis of Inaoside A. Asian Journal of Organic Chemistry. 2024
Atsushi Kawamura, Aira Mizuno, Mayuri Kurakake, Akiyoshi Yamada, Hidefumi Makabe. Inaoside A: New antioxidant phenolic compound from the edible mushroom Laetiporus cremeiporus. Heliyon. 2024. 10. 3. e24651-e24651
Yuki Kameyama, Hidefumi Makabe. Application of Pd-catalyzed carbonylation followed by spontaneous oxa-Michael addition/diastereoselective reduction of ynone: Synthesis of (+)-goniofufurone. Tetrahedron Letters. 2023. 154827-154827
Katsunori Endo, Toko Sawa, Yuna Tanaka, Takeru Saiki, Hazuki Haga, Lana Rizeq, Haruka Aso, Momoka Isono, Fumie Niitsuma, Akihiro Masaki, et al. Oral administration of procyanidin B2 3,3"-di-O-gallate ameliorates experimental autoimmune encephalomyelitis through immunosuppressive effects on CD4+ T cells by regulating glycolysis. European Journal of Pharmacology. 2023. 954. 175879-175879

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MISC (25)：

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Books (7)：

The Biological Activities and Synthesis of 2,6-Disubstituted Piperidinols
2017
Studies on prodelphinidins: isolation, synthesis, and their biological activities
ELSEVIER SCIENCE PUBLISHERS - AMSTERDAM 2016
Recent progress of the synthesis of 2,6-disubstituted hydroxypiperidine alkaloids
ELSEVIER SCIENCE PUBLISHERS - AMSTERDAM 2014
(-)-Epicatechin 3-(3”-O-methylgallate) and (+)-catechin 3-(3”-O-methylgallate), and Their anti-inflammatory activity
Elsevier, Victor R. Preedy Eds. 2012
みすずかる信濃の健康志向食品、9章昆虫食の時代がやってくる!
郷土出版社 2003

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Lectures and oral presentations (7)：

癌転移原因遺伝子FABP5を分子標的とした抗腫瘍性エピゲノム制御因子の同定と作用機構の解析
(第36回日本分子生物学学会年会 2013)
Development of Pd Catalyzed Stereoselective Cyclization and its Application for Synthesis of Natural Products
(4th Asia-Pacific Conference on Chemical Ecology 2007)
An efficient synthesis of procyanidins catalyzedby rare earthmetal Lewis acid
(14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, Nara, Japan, 2-6 August, 2007 2007)
Synthesis of Pyranicin via Pd(II) Catalyzed Diastereoselective Cyclization
(14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, Nara, Japan, 2-6 August, 2007 2007)
Total Synthesis of Murisolin, Murisolin A, and 16, 19-cis-Murisolin
(ICOB-5&ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products 2006)

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Education (2)：

Professional career (1)：

Work history (3)：

2019/04 - 現在信州大学先鋭領域融合研究群バイオメディカル研究所
2014/04/01 - Shinshu University Interdisciplinary Cluster for Cutting Edge Research, Institute for Biomedical Sciences
2014/01/01 - 信州大学学術研究院農学系教授

Committee career (1)：

Awards (2)：

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