Kosaka Akemi

コサカアケミ | Kosaka Akemi

Affiliation and department：

Research field (1)： Immunology

Research theme for competitive and other funds (12)：

2025 - 2028 免疫抑制性腫瘍微小環境の打破に関わる基盤的複合癌免疫療法の開発研究
2025 - 2028 非炎症性腫瘍に対するSTINGとRIG-Iを標的としたがん免疫療法の開発
2023 - 2026 がん免疫治療の奏効率向上を目指した腫瘍微小環境内の良質な炎症状態の誘導戦略
2022 - 2025 STINGアゴニストを用いたTNBCに対する効果的ながん免疫療法の開発
2022 - 2025 cGAS/STING/I型IFN経路を基軸とした癌免疫微小環境のホット化治療戦略

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Papers (45)：

Ryosuke Sato, Hidekiyo Yamaki, Takahiro Inoue, Shota Sakaue, Hisataka Ominato, Risa Wakisaka, Hiroki Komatsuda, Michihisa Kono, Kenzo Ohara, Akemi Kosaka, et al. ROR1 as an Immunotherapeutic Target for Inducing Antitumor Helper T Cell Responses Against Head and Neck Squamous Cell Carcinoma. Cancers. 2025. 17. 14. 2326-2326
Hiroki Komatsuda, Toshihiro Nagato, Akemi Kosaka, Takayuki Ohkuri, Takaaki Sasaki, Takumi Kumai, Michihisa Kono, Hidekiyo Yamaki, Risa Wakisaka, Shunsuke Yasuda, et al. Tumor-promoting function of paternally expressed gene 10 and its immunogenicity in inducing anti-tumor helper T cells in head and neck squamous cell carcinoma. Cancer Immunology, Immunotherapy. 2025. 74. 8
Sato R., Inoue T., Wakisaka R., Komatsuda H., Kono M., Yamaki H., Ohara K., Kumai T., Kosaka A., Ohkuri T., et al. Differences in PD-L1, PD-L2, and EGFR Expression Between Naive and Recurrent Tumors in Patients With Head and Neck Squamous Cell Carcinoma: A Retrospective Study. Head & Neck. 2025
Wakisaka R, Yamaki H, Kono M, Inoue T, Sato R, Komatsuda H, Ohara K, Kosaka A, Ohkuri T, Nagato T, Kishibe K, Nakayama K, Kobayashi H, Kumai T, Takahara M. Hypoxia-Targeted Immunotherapy with PD-1 Blockade in Head and Neck Cancer. Cancers. 2024. 16. 17. 3013-3013
Kono M., Wakisaka R., Komatsuda H., Hayashi R., Kumai T., Yamaki H., Sato R., Nagato T., Ohkuri T., Kosaka A., et al. Immunotherapy targeting tumor-associated antigen in a mouse model of head and neck cancer. Head and Neck. 2024. 46. 8. 2056-2067

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MISC (5)：

Patents (2)：

がん抗原ペプチド
がん抗原ペプチド

Lectures and oral presentations (10)：

Development of cancer immunotherapy targeting STING and RIG-I
Effects of tumor-derived IL-6 on the tumor microenvironment and anti-tumor immune responses
(第83回日本癌学会学術総会)
Development of a combination therapy of STING agonist and IL-6 receptor inhibitor for TNBC
(第113回日本病理学会総会)
Characterization of moDCs in the tumor-draining LNs by intratumoral colchicine-induced tumor vascular disruption
(第82回日本癌学会学術総会)
Comparison of type I IFN-induced agonists in the tumor microenvironment
(第112回日本病理学会総会)

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Professional career (1)：

博士 (理学) (北海道大学)

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