Kobayashi Maki

コバヤシマキ | Kobayashi Maki

Affiliation and department：

Research field (1)： Medical biochemistry

Research keywords (1)：クラススイッチ

Research theme for competitive and other funds (11)：

2022 - 2025 効率的な抗体遺伝子組換えにおける液ー液相分離複合体の重要性の解析
2022 - 2025 Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification
2019 - 2022 Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID
2019 - 2022 Transcription-dependent IgH gene instability by RNA interference
2016 - 2019 Molecular mechanism of genomic instability by RNA editing

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Papers (33)：

Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda, Tasuku Honjo. Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase. Proceedings of the National Academy of Sciences. 2023. 120. 18. e2216918120
Wajid Amin, Shoki Nishio, Tasuku Honjo, Maki Kobayashi. Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification. International Immunology. 2023
Afzal Husain, Jianliang Xu, Hodaka Fujii, Mikiyo Nakata, Maki Kobayashi, Ji-Yang Wang, Jan Rehwinkel, Tasuku Honjo, Nasim A Begum. SAMHD 1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. The EMBO Journal. 2020. 39. 15
Ziwei Yin, Maki Kobayashi, Wenjun Hu, Koichi Higashi, Nasim A. Begum, Ken Kurokawa, Tasuku Honjo. RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase. Proceedings of the National Academy of Sciences. 2020. 117. 21. 11624-11635
Afzal Husain, Nasim Begum, Maki Kobayashi, Tasuku Honjo. Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells. BIO-PROTOCOL. 2020. 10. 23

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MISC (1)：

NAGAOKA Hitoshi, TRAN Thinh Huy, KOBAYASHI Maki, AIDA Masatoshi, HONJO Tasuku. Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity. Int Immunol. 2010. 22. 4. 227-235

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