Rchr
J-GLOBAL ID：200901028740860330   Update date: Aug. 05, 2022

Yamamoto Chika

ヤマモト チカ | Yamamoto Chika
Affiliation and department：
Toho University Faculty of Pharmaceutical Sciences

About Toho University Faculty of Pharmaceutical Sciences


Job title： Associate Professor
Research field  (1)： Pharmaceuticals - health and biochemistry
Research keywords  (6)： プロテオグリカンの細胞生物学 ,  血管内皮細胞の機能調節 ,  重金属毒性 ,  Cell Biology of Proteoglycans ,  Regulation of Vascular Endothelial Cell Functions ,  Heavy Metal Toxicity
Research theme for competitive and other funds  (17)：
  • 2018 - 2021 Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells
  • 2015 - 2018 Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices
  • 2012 - 2016 Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression
  • 2011 - 2014 Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity
  • 2006 - 2010 Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury
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Papers (199)：
  • Tomoya Fujie, Keisuke Ito, Yusuke Ozaki, Suzuka Takahashi, Chika Yamamoto, Toshiyuki Kaji. Induction of ZIP8, a ZIP transporter, via NF-κB signaling by the activation of IκBα and JNK signaling in cultured vascular endothelial cells exposed to cadmium. Toxicology and Applied Pharmacology. 2022. 434. 115802-115802
  • Keisuke Ito, Tomoya Fujie, Masahiro Shimomura, Tsuyoshi Nakano, Chika Yamamoto, Toshiyuki Kaji. TGF-β1 Potentiates the Cytotoxicity of Cadmium by Induction of a Metal Transporter, ZIP8, Mediated by the ALK5-Smad2/3 and ALK5-Smad3-p38 MAPK Signal Pathways in Cultured Vascular Endothelial Cells. International Journal of Molecular Sciences. 2021. 23. 1. 448-448
  • Musubu Takahashi, Tomoya Fujie, Tsuyoshi Nakano, Takato Hara, Yasuhiro Shinkai, Ryoko Takasawa, Yasushi Hara, Yoshito Kumagai, Chika Yamamoto, Toshiyuki Kaji. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β1: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways. International Journal of Molecular Sciences. 2021. 22. 21. 11762-11762
  • Takato Hara, Takahiro Okazaki, Tamayo Hashiya, Kyohei Nozawa, Shuji Yasuike, Jyoji Kurita, Chika Yamamoto, Noriaki Hamada, Toshiyuki Kaji. Effects of Substitution on Cytotoxicity of Diphenyl Ditelluride in Cultured Vascular Endothelial Cells. International Journal of Molecular Sciences. 2021. 22. 19. 10520-10520
  • Takato Hara, Arisa Sato, Chika Yamamoto, Toshiyuki Kaji. Syndecan-1 downregulates syndecan-4 expression by suppressing the ERK1/2 and p38 MAPK signaling pathways in cultured vascular endothelial cells. Biochemistry and Biophysics Reports. 2021. 26. 101001-101001
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MISC (15)：
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Books (5)：
  • スタンダード薬学シリーズII 薬学演習I(スタンダード薬学シリーズII-9)
    東京化学同人 2020 ISBN:9784807917235
  • コンパス衛生薬学(改訂第3版): 健康と環境(鍜冶利幸・佐藤雅彦編集)
    南江堂 2020 ISBN:9784524403714
  • スタンダード薬学シリーズ II 5 衛生薬学 : 健康と環境(日本薬学会編)
    東京化学同人 2019 ISBN:9784807917112
  • コンパス衛生薬学(改訂第2版): 健康と環境(鍜冶利幸・佐藤雅彦編集)
    南江堂 2016 ISBN:9784524403226
  • 保健環境論
    京都廣川書店 2014 ISBN:9784906992355
Works (4)：
  • Joint Research on the Biological Activities of Sodium Spirulan
    2000 -
  • 血管細胞プロテオグリカンに関する共同研究
    1994 -
  • Joint Research on Proteoglycans in Vascular cells
    1994 -
  • ナトリウムスピルランの生物活性に関する共同研究
Education (2)：
  • 1997 - 博士(薬学)学位取得 富山医科薬科大学
  • - 1990 Hokuriku University Department of Hygienic Pharmacy
Professional career (1)：
  • (BLANK) (*Toyama Medical and Pharmaceutical University*)
Work history (8)：
  • 2013/04 - 現在 東京理科大学 総合研究機構 客員教授(兼任)
  • 2013/04 - 現在 Toho University Faculty of Pharmaceutical Sciences
  • 2012/04 - 2013/03 東京理科大学 総合研究機構 客員准教授(兼任)
  • 2007/05 - 2013/03 Hokuriku University Faculty of Pharmaceutical Sciences
  • 2006/04 - 2007/05 Hokuriku University Faculty of Pharmaceutical Sciences
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Awards (2)：
  • 2018/07 - Pfizer Highly Cited Paper Award The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules. J. Toxicol. Sci. Vol.40, No.3, 321-327, 2015
  • 2005/10 - 日本薬学会 環境・衛生部会 環境・衛生部会賞 動脈硬化の進展メカニズムと防御に関する衛生薬学的研究
Association Membership(s) (6)：
日本毒性学会 評議員 ,  日本糖質学会 ,  日本生化学会 ,  日本結合組織学会 ,  日本薬学会 ,  THE JAPANESE SOCIETY OF TOXICOLOGY
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