Research field (1)：
Pharmaceuticals - health and biochemistry
Research keywords (6)：
プロテオグリカンの細胞生物学
, 血管内皮細胞の機能調節
, 重金属毒性
, Cell Biology of Proteoglycans
, Regulation of Vascular Endothelial Cell Functions
, Heavy Metal Toxicity
Research theme for competitive and other funds (17)：
2018 - 2021 Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells
2015 - 2018 Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices
2012 - 2016 Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression
2011 - 2014 Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity
2006 - 2010 Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury
2006 - 2008 Regulation of proteoglycan metabolism by adiponectin in vascular smooth muscle cells
2004 - 2006 Regulation of glycosmainoglycan chain formation in proteoglycan molecules synthesized by brain vascular cells
2002 - 2004 Characterization of proteoglycans expressed in brain vascular cells and regulation of their synthesis
2002 - 2004 脳毛細血管内皮細胞と周皮細胞における線溶蛋白の発現および増殖因子による調節
1999 - 2001 細胞増殖因子による血管内皮細胞プロテオグリカン分子種の合成調節
1997 - 1999 Clarification of characteristics, functions and regulation of proteoglycans synthesized by pericytes
1996 - 1997 重金属による血液線溶系の撹乱を介在する細胞内情報電圧経路
1995 - 1996 重金属による血管内皮細胞線溶調節の傷害メカニズム
Regulation of Proteoglycan Metabolism in Vascular Endothelial Cell and Vascular Smooth Muscle Cells
Regulation of the Functions of Vascular Endothelial Cells and Vascular Smooth-Muscle Cells
Analysis of the Mechanism for the Exhibition of Heavy Metal Toxicity Uning Cell Culture Systems
Tsutomu Takahashi, Yuka Takagi, Yuta Honma, Yo Shinoda, Yayoi Tsuneoka, Takato Hara, Chika Yamamoto, Toshiyuki Kaji, Yasuyuki Fujiwara. Nucleolin positively regulates spontaneous cell proliferation but is not involved in inhibition of proliferation by lead in cultured bovine aortic endothelial cells. Fundamental Toxicological Sciences. 2020. 7. 5. 233-239
Joint Research on the Biological Activities of Sodium Spirulan
2000 -
血管細胞プロテオグリカンに関する共同研究
1994 -
Joint Research on Proteoglycans in Vascular cells
1994 -
ナトリウムスピルランの生物活性に関する共同研究
Education (2)：
1997 - 博士(薬学)学位取得 富山医科薬科大学
- 1990 Hokuriku University Department of Hygienic Pharmacy
Professional career (1)：
(BLANK) (*Toyama Medical and Pharmaceutical University*)
Work history (8)：
2013/04 - 現在 東京理科大学 総合研究機構 客員教授(兼任)
2013/04 - 現在 Toho University Faculty of Pharmaceutical Sciences
2012/04 - 2013/03 東京理科大学 総合研究機構 客員准教授(兼任)
2007/05 - 2013/03 Hokuriku University Faculty of Pharmaceutical Sciences
2006/04 - 2007/05 Hokuriku University Faculty of Pharmaceutical Sciences
2001/04 - 2006/03 Hokuriku University Faculty of Pharmaceutical Sciences
1992/04 - 2001/03 Hokuriku University Faculty of Pharmaceutical Sciences
1990/04 - 1992/03 Hokuriku University Faculty of Pharmaceutical Sciences
Show all
Awards (2)：
2018/07 - Pfizer Highly Cited Paper Award The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules. J. Toxicol. Sci. Vol.40, No.3, 321-327, 2015
