Research field (2)：
Environmental and hygienic pharmacy
, Biological pharmacy
Research keywords (3)：
Heavy Metal Toxicity
, Regulation of Vascular Endothelial Cell Functions
, Cell Biology of Proteoglycans
Research theme for competitive and other funds (12)：
2018 - 2021 Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells
2015 - 2018 Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices
2012 - 2016 Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression
2011 - 2014 Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity
2006 - 2010 Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury
2006 - 2008 Regulation of proteoglycan metabolism by adiponectin in vascular smooth muscle cells
2004 - 2006 Regulation of glycosmainoglycan chain formation in proteoglycan molecules synthesized by brain vascular cells
2002 - 2004 Characterization of proteoglycans expressed in brain vascular cells and regulation of their synthesis
1997 - 1999 Clarification of characteristics, functions and regulation of proteoglycans synthesized by pericytes
Analysis of the Mechanism for the Exhibition of Heavy Metal Toxicity Uning Cell Culture Systems
Regulation of the Functions of Vascular Endothelial Cells and Vascular Smooth-Muscle Cells
Regulation of Proteoglycan Metabolism in Vascular Endothelial Cell and Vascular Smooth Muscle Cells
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Papers (112)：
Tomoya Fujie, Taro Yamamoto, Chika Yamamoto, and Toshiyuki Kaji. Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridiolato)zinc(II) exhibits strong cytotoxicity and a high intracellular accumulation in cultured vascular endothelial cells. The Journal of Toxicological Sciences. 2019. 44. 113-120
Tomoya Fujie, Fukuta Takenaka, Eiko Yoshida, Shuji Yasuike, Yasuyuki Fujiwara, Yasuhiro Shinkai, Yoshito Kumagai, Chika Yamamoto, and Toshiyuki Kaji. Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris (pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells. The Journal of Toxicological Sciences. 2019. 44. 327-333
Takato Hara, Shihoko Nakano, Yuki Kitamura, Chika Yamamoto, Shuji Yasuike, and Toshiyuki Kaji. Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells. The Journal of Toxicological Sciences. 2019. 44. 845-848
Takato Hara, Takako Wakata, Yasuyuki Fujiwara, Chika Yamamoto, and Toshiyuki Kaji. Induction of versican V0 variant synthesis by a thrombin receptor agonist peptide?in cultured human coronary smooth muscle cells. BPB Reports. 2019. 2. 106-112
Takato Hara, Hiroko Tatsuishi, Tomomi Banno, Tomoya Fujie, Chika Yamamoto, Hiroshi Naka, and Toshiyuki Kaji. Copper(II) bis(diethyldithiocarbamate) induces the expression of syndecan-4, a transmembrane heparan sulfate proteoglycan, via p38 MAPK activation in vascular endothelial cells. International Journal of Molecular Sciences. 2018. 19. 3302
