J-GLOBAL ID:200901028740860330   Update date: Jan. 09, 2020


ヤマモト チカ | YAMAMOTO Chika
Affiliation and department:
Job title: Associate Professor
Research field  (2): Environmental and hygienic pharmacy ,  Biological pharmacy
Research keywords  (3): Heavy Metal Toxicity ,  Regulation of Vascular Endothelial Cell Functions ,  Cell Biology of Proteoglycans
Research theme for competitive and other funds  (12):
  • 2018 - 2021 Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells
  • 2015 - 2018 Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices
  • 2012 - 2016 Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression
  • 2011 - 2014 Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity
  • 2006 - 2010 Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury
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Papers (112):
  • Tomoya Fujie, Taro Yamamoto, Chika Yamamoto, and Toshiyuki Kaji. Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridiolato)zinc(II) exhibits strong cytotoxicity and a high intracellular accumulation in cultured vascular endothelial cells. The Journal of Toxicological Sciences. 2019. 44. 113-120
  • Tomoya Fujie, Fukuta Takenaka, Eiko Yoshida, Shuji Yasuike, Yasuyuki Fujiwara, Yasuhiro Shinkai, Yoshito Kumagai, Chika Yamamoto, and Toshiyuki Kaji. Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris (pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells. The Journal of Toxicological Sciences. 2019. 44. 327-333
  • Takato Hara, Shihoko Nakano, Yuki Kitamura, Chika Yamamoto, Shuji Yasuike, and Toshiyuki Kaji. Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells. The Journal of Toxicological Sciences. 2019. 44. 845-848
  • Takato Hara, Takako Wakata, Yasuyuki Fujiwara, Chika Yamamoto, and Toshiyuki Kaji. Induction of versican V0 variant synthesis by a thrombin receptor agonist peptide?in cultured human coronary smooth muscle cells. BPB Reports. 2019. 2. 106-112
  • Takato Hara, Hiroko Tatsuishi, Tomomi Banno, Tomoya Fujie, Chika Yamamoto, Hiroshi Naka, and Toshiyuki Kaji. Copper(II) bis(diethyldithiocarbamate) induces the expression of syndecan-4, a transmembrane heparan sulfate proteoglycan, via p38 MAPK activation in vascular endothelial cells. International Journal of Molecular Sciences. 2018. 19. 3302
MISC (48):
Works (2):
  • Joint Research on Proteoglycans in Vascular cells
    1994 -
  • Joint Research on the Biological Activities of Sodium Spirulan
    2000 -
Professional career (1):
  • (BLANK) (*Toyama Medical and Pharmaceutical University*)
Association Membership(s) (1):
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