Rchr
J-GLOBAL ID:200901028856864758
Update date: Nov. 05, 2024
Kondo Yutaka
コンドウ ユタカ | Kondo Yutaka
Affiliation and department:
Job title:
Professor
Homepage URL (2):
https://www.med.nagoya-u.ac.jp/medical_J/laboratory/basic-med/oncology/cancer-bio/
,
http://www.pref.aichi.jp/cancer-center/english/ri/01division/10epigenomics/index.html
Research field (2):
Medical biochemistry
, Molecular biology
Research keywords (7):
エピジェネティクス
, 発癌
, 消化器癌
, 腫瘍
, carcino genesis
, colon cancer and Hepatoma
, Cancer
Research theme for competitive and other funds (23):
- 2020 - 2023 DNA損傷時のエピゲノム修復における長鎖非翻訳RNAの役割と発がんへの関与
- 2020 - 2023 Exploratory analysis of DNA methylation as a novel biomarker in gastrointestinal cancer chemotherapy
- 2020 - 2023 A study of mechanism of resolving DNA replication stress by long non-coding RNA in cancer cell
- 2019 - 2023 Dynamic regulation of cancer associated fibroblast via functional RNA as a novel therapeutic target for pancreas cancer
- 2017 - 2020 Long non-coding RNA as an epigenetic modulator in cancer cells
- 2016 - 2019 Super-enhancer and dynamic chromatine remodeling in gliomagenesis
- 2016 - 2019 Mogamulizumab induced immune related adverse events; the impact of Treg depletion
- 2014 - 2017 Identification of novel EZH2 mechanism and its network in cancer cells
- 2014 - 2017 Control of transcription factors and epigenetic factors via nuclear transport and its application to targeted therapy
- 2013 - 2017 Study of regulatory mechanism controlling cancer cell reprogramming
- 2014 - 2016 Identification of a novel tumor-associated protein in gliomagenesis and chemicals targeting its function.
- 2012 - 2016 DNA methylation mapping device for cancer epigenome analysis
- 2010 - 2014 Epigenetic plasticity as a novel target for cancer treatment
- 2010 - 2012 Comprehensive analyses of IL28B genetic factor toward tailor-made therapy for chronic hepatitis C
- 2009 - 2011 Chemical biology reprogramming epigenetic aberration in malignant brain tumors
- 2008 - 2009 Analyses of DNA methylation and histone methylation changes in human malignancies
- 2008 - 2009 がん幹細胞を規定するエピジェネティックな分子基盤を標的とした新規治療薬の開発
- 2007 - 2008 Genome-wide Analysis of Hypermethylated Genes in Colon Cancer with Liver Metastasis
- 2007 - 2008 Genetic alternation of metastatic and recurrent gastrointestinal stromal tumor (GIST)
- 2006 - 2007 Influence of hepatitis B virus core promoter mutations on hepatocellular carcinoma among Japanese patients
- 2006 - 2007 Roles of Histone Methyltransferase in Human Cancer
- 2005 - Basic oncology
- ヒトがんにおけるエピジェネティクス異常の解析
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Papers (177):
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Ryosuke Sonobe, Peng Yang, Miho M. Suzuki, Keiko Shinjo, Kenta Iijima, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka, Hiroaki Kajiyama, Yutaka Kondo. Long noncoding RNATUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta. Cancer Science. 2024
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Katsunobu Kashiwagi, Junko Yoshida, Hiroshi Kimura, Keiko Shinjo, Yutaka Kondo, Kyoji Horie. Mutation of the SWI/SNF complex component Smarce1 decreases nucleosome stability in embryonic stem cells and impairs differentiation. Journal of Cell Science. 2024. 137. 6
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Kojiro Ishibashi, Toshiya Ichinose, Riki Kadokawa, Ryo Mizutani, Sadahiro Iwabuchi, Sumihito Togi, Hiroki Ura, Shoichiro Tange, Keiko Shinjo, Jun Nakayama, et al. Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR. Developmental Cell. 2024
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Miho M Suzuki, Kenta Iijima, Koichi Ogami, Keiko Shinjo, Yoshiteru Murofushi, Jingqi Xie, Xuebing Wang, Yotaro Kitano, Akira Mamiya, Yuji Kibe, et al. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation. Nature communications. 2023. 14. 1. 4521-4521
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Ayako Muraoka, Miho Suzuki, Tomonari Hamaguchi, Shinya Watanabe, Kenta Iijima, Yoshiteru Murofushi, Keiko Shinjo, Satoko Osuka, Yumi Hariyama, Mikako Ito, et al. Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Science translational medicine. 2023. 15. 700. eadd1531
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MISC (115):
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田崎 慶彦, 勝島 啓佑, 新城 恵子, 鈴木 美穂, 飯島 健太, 宮田 完二郎, 片岡 一則, 木村 和哲, 近藤 豊. 膵臓がんにおけるLncRNA TUG1を標的とした治療の有効性の検討. 日本癌学会総会記事. 2020. 79回. OE14-2
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田崎 慶彦, 勝島 啓佑, 新城 恵子, 飯島 健太, 宮田 完二郎, 片岡 一則, 近藤 豊. 膵臓がんに対する長鎖非翻訳RNA,TUG1と5FUの効果(Effect of combination therapy with non-coding RNA, TUG1 and 5FU in pancreatic cancer). 日本癌学会総会記事. 2019. 78回. P-3115
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田崎 慶彦, 勝島 啓祐, 片岡 一則, 木村 和哲, 近藤 豊. エピジェネティクス研究最前線 基礎から創薬応用まで多角的に捉える 膵臓がんに対するTUG1を標的としたアンチセンスオリゴの抗腫瘍効果. 日本薬学会年会要旨集. 2019. 139年会. 1. 324-324
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田崎 慶彦, 勝島 啓佑, 新城 恵子, 鈴木 美穂, 戸谷 治仁, 間瀬 聖子, 村嶋 明大, 宮田 完二郎, 片岡 一則, 木村 和哲, et al. 膵臓がんにおける長鎖非翻訳RNA,TUG1の役割(Tumorigenic role of non-coding RNA, TUG1 in pancreatic cancer). 日本癌学会総会記事. 2018. 77回. 2096-2096
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田崎 慶彦, 勝島 啓佑, 木村 和哲, 近藤 豊. 【がん転移学(上)-がん転移のメカニズムと治療戦略:その基礎と臨床-】がん転移学の基礎研究 がん幹細胞とエピゲノム制御. 日本臨床. 2017. 75. 増刊8 がん転移学(上). 137-143
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Lectures and oral presentations (19):
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膠芽腫に対する核酸治療薬の開発を目指して
(2022)
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脳腫瘍に対する新規LSD1阻害剤の治療効果
(第26回日本がん分子標的治療学会学術集会 2022)
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がん細胞における長鎖非翻訳RNA TUG1によるR-loopの解消機構
(2022)
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新規LSD1阻害剤の開発と脳腫瘍に対する治療効果
(2022)
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R-loop調節における長鎖非翻訳RNA TUG1の機能
(2022)
more...
Professional career (1):
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