Kondo Yutaka

コンドウユタカ | Kondo Yutaka

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.med.nagoya-u.ac.jp/medical_J/laboratory/basic-med/oncology/cancer-bio/ , http://www.pref.aichi.jp/cancer-center/english/ri/01division/10epigenomics/index.html

Research field (2)： Medical biochemistry , Molecular biology

Research keywords (7)：エピジェネティクス , 発癌 , 消化器癌 , 腫瘍 , carcino genesis , colon cancer and Hepatoma , Cancer

Research theme for competitive and other funds (23)：

2020 - 2023 DNA損傷時のエピゲノム修復における長鎖非翻訳RNAの役割と発がんへの関与
2020 - 2023 Exploratory analysis of DNA methylation as a novel biomarker in gastrointestinal cancer chemotherapy
2020 - 2023 A study of mechanism of resolving DNA replication stress by long non-coding RNA in cancer cell
2019 - 2023 Dynamic regulation of cancer associated fibroblast via functional RNA as a novel therapeutic target for pancreas cancer
2017 - 2020 Long non-coding RNA as an epigenetic modulator in cancer cells

2016 - 2019 Super-enhancer and dynamic chromatine remodeling in gliomagenesis

2016 - 2019 Mogamulizumab induced immune related adverse events; the impact of Treg depletion

2014 - 2017 Identification of novel EZH2 mechanism and its network in cancer cells

2014 - 2017 Control of transcription factors and epigenetic factors via nuclear transport and its application to targeted therapy

2013 - 2017 Study of regulatory mechanism controlling cancer cell reprogramming

2014 - 2016 Identification of a novel tumor-associated protein in gliomagenesis and chemicals targeting its function.

2012 - 2016 DNA methylation mapping device for cancer epigenome analysis

2010 - 2014 Epigenetic plasticity as a novel target for cancer treatment

2010 - 2012 Comprehensive analyses of IL28B genetic factor toward tailor-made therapy for chronic hepatitis C

2009 - 2011 Chemical biology reprogramming epigenetic aberration in malignant brain tumors

2008 - 2009 Analyses of DNA methylation and histone methylation changes in human malignancies

2008 - 2009 がん幹細胞を規定するエピジェネティックな分子基盤を標的とした新規治療薬の開発

2007 - 2008 Genome-wide Analysis of Hypermethylated Genes in Colon Cancer with Liver Metastasis

2007 - 2008 Genetic alternation of metastatic and recurrent gastrointestinal stromal tumor (GIST)

2006 - 2007 Influence of hepatitis B virus core promoter mutations on hepatocellular carcinoma among Japanese patients

2006 - 2007 Roles of Histone Methyltransferase in Human Cancer

2005 - Basic oncology

ヒトがんにおけるエピジェネティクス異常の解析

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Papers (174)：

Miho M Suzuki, Kenta Iijima, Koichi Ogami, Keiko Shinjo, Yoshiteru Murofushi, Jingqi Xie, Xuebing Wang, Yotaro Kitano, Akira Mamiya, Yuji Kibe, et al. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation. Nature communications. 2023. 14. 1. 4521-4521
Ayako Muraoka, Miho Suzuki, Tomonari Hamaguchi, Shinya Watanabe, Kenta Iijima, Yoshiteru Murofushi, Keiko Shinjo, Satoko Osuka, Yumi Hariyama, Mikako Ito, et al. Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Science translational medicine. 2023. 15. 700. eadd1531
Kentaro Imai, Takuji Ishimoto, Tomohito Doke, Toshiki Tsuboi, Yu Watanabe, Keisuke Katsushima, Miho Suzuki, Hideto Oishi, Kazuhiro Furuhashi, Yasuhiko Ito, et al. Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells. Molecular therapy. Nucleic acids. 2023. 31. 139-150
Junya Yamaguchi, Fumiharu Ohka, Yotaro Kitano, Sachi Maeda, Kazuya Motomura, Kosuke Aoki, Kazuhito Takeuchi, Yuichi Nagata, Hikaru Hattori, Takashi Tsujiuchi, et al. Rapid detection of the MYD88 L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma. Cancer science. 2023. 114. 6. 2544-2551
Junya Yamaguchi, Fumiharu Ohka, Chalise Lushun, Kazuya Motomura, Kosuke Aoki, Kazuhito Takeuchi, Yuichi Nagata, Satoshi Ito, Nobuhiko Mizutani, Masasuke Ohno, et al. CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma. Cancer medicine. 2022. 12. 6. 7116-7126

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MISC (115)：

田崎慶彦, 勝島啓佑, 新城恵子, 鈴木美穂, 飯島健太, 宮田完二郎, 片岡一則, 木村和哲, 近藤豊. 膵臓がんにおけるLncRNA TUG1を標的とした治療の有効性の検討. 日本癌学会総会記事. 2020. 79回. OE14-2
田崎慶彦, 勝島啓佑, 新城恵子, 飯島健太, 宮田完二郎, 片岡一則, 近藤豊. 膵臓がんに対する長鎖非翻訳RNA,TUG1と5FUの効果(Effect of combination therapy with non-coding RNA, TUG1 and 5FU in pancreatic cancer). 日本癌学会総会記事. 2019. 78回. P-3115
田崎慶彦, 勝島啓祐, 片岡一則, 木村和哲, 近藤豊. エピジェネティクス研究最前線基礎から創薬応用まで多角的に捉える膵臓がんに対するTUG1を標的としたアンチセンスオリゴの抗腫瘍効果. 日本薬学会年会要旨集. 2019. 139年会. 1. 324-324
田崎慶彦, 勝島啓佑, 新城恵子, 鈴木美穂, 戸谷治仁, 間瀬聖子, 村嶋明大, 宮田完二郎, 片岡一則, 木村和哲, et al. 膵臓がんにおける長鎖非翻訳RNA,TUG1の役割(Tumorigenic role of non-coding RNA, TUG1 in pancreatic cancer). 日本癌学会総会記事. 2018. 77回. 2096-2096
田崎慶彦, 勝島啓佑, 木村和哲, 近藤豊. 【がん転移学(上)-がん転移のメカニズムと治療戦略:その基礎と臨床-】がん転移学の基礎研究がん幹細胞とエピゲノム制御. 日本臨床. 2017. 75. 増刊8 がん転移学(上). 137-143

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Lectures and oral presentations (19)：

膠芽腫に対する核酸治療薬の開発を目指して
(2022)
脳腫瘍に対する新規LSD1阻害剤の治療効果
(第26回日本がん分子標的治療学会学術集会 2022)
がん細胞における長鎖非翻訳RNA TUG1によるR-loopの解消機構
(2022)
新規LSD1阻害剤の開発と脳腫瘍に対する治療効果
(2022)
R-loop調節における長鎖非翻訳RNA TUG1の機能
(2022)

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Professional career (1)：

MD, PhD

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