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J-GLOBAL ID：200901028991514112   Update date: Nov. 25, 2024

Uto Tomofumi

ウト トモフミ | Uto Tomofumi
Affiliation and department：
University of Miyazaki Faculty of Medicine, School of Medicine

About University of Miyazaki Faculty of Medicine, School of Medicine


Research field  (5)： Tumor diagnostics and therapeutics ,  Nanobioscience ,  Immunology ,  Virology ,  Molecular biology
Research keywords  (6)： がん ,  アレルギー ,  免疫 ,  ナノテクノロジー ,  ワクチン ,  樹状細胞
Research theme for competitive and other funds  (3)：
  • 2023 - 2026 新規ヒト樹状細胞発現免疫チェックポイント分子を標的とした阻害剤の開発
  • 2020 - 2023 ヒト樹状細胞を標的とした新規免疫チェックポイント阻害剤の開発
  • 2017 - 2020 Analysis of cancer immune regulation mechanism by new immune checkpoint molecule Clec4A4
Papers (47)：
  • Baljinnyam Lkham-Erdene, Narantsog Choijookhuu, Toshiki Kubota, Tomofumi Uto, Shuya Mitoma, Shinichiro Shirouzu, Takumi Ishizuka, Kengo Kai, Kazuhiro Higuchi, Kham Mo Aung, et al. Effect of Hepatic Lipid Overload on Accelerated Hepatocyte Proliferation Promoted by HGF Expression via the SphK1/S1PR2 Pathway in MCD-diet Mouse Partial Hepatectomy. Acta histochemica et cytochemica. 2024. 57. 5. 175-188
  • Moe Tominaga, Tomofumi Uto, Tomohiro Fukaya, Shuya Mitoma, Dieter Riethmacher, Kunihiko Umekita, Yoshihiro Yamashita, Katsuaki Sato. Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development. Frontiers in immunology. 2024. 15. 1200461-1200461
  • Tomofumi Uto, Tomohiro Fukaya, Shuya Mitoma, Yotaro Nishikawa, Moe Tominaga, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato. Clec4A4 Acts As A Negative Immune Checkpoint Regulator to Suppress Antitumor Immunity. Cancer immunology research. 2023. 11. 9. 1266-1279
  • Tomohiro Fukaya, Tomofumi Uto, Shuya Mitoma, Hideaki Takagi, Yotaro Nishikawa, Moe Tominaga, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato. Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells. Cell reports. 2023. 42. 5. 112431-112431
  • Masami Ukawa, Rikito Endo, Haruya Yagi, Takumi Tomono, Kohei Miyata, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma. Mechanism on antigen delivery under mucosal vaccination using cell-penetrating peptides immobilized at multiple points on polymeric platforms. International Journal of Pharmaceutics. 2022. 613. 121376-121376
ｍore...
MISC (4)：
Patents (3)：
  • POLYION COMPLEX COMPRISING HYDROPHOBIZED POLYAMINO ACID AND USE OF THE SAME
  • 疎水化ポリアミノ酸からなるポリイオンコンプレッ クスとその用途
  • 抗食物アレルギーワクチン
Books (15)：
  • 樹状細胞のはたらき 7 がん免疫応答における通常型樹状細胞の役割
    獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2024
  • 樹状細胞のはたらき 6 アレルギー疾患に対する舌下免疫療法の防御効果における樹状細胞の役割
    獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2024
  • 樹状細胞のはたらき 5 幼若期での抗生剤服用による消化管細菌叢異常に基づく経口免疫寛容の破綻における通常型樹状細胞の役割
    獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2024
  • 樹状細胞のはたらき 4 経口免疫寛容の誘導における形質細胞様樹状細胞の役割
    獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2024
  • 樹状細胞のはたらき 3 樹状細胞による制御性T細胞の制御
    獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2023
ｍore...
Lectures and oral presentations  (42)：
  • Clec4A4 acts as a negative immune checkpoint regulator to suppress antitumor immunity
    (2nd Edition of the Global Meeting on Cancer Research and Therapy (GMCRT-2024) 2024)
  • Clec4A4 serves as a negative immune checkpoint regulator expressed on conventional dendritic cells to impair antitumor immunity
    (第52回日本免疫学会学術集会 2024)
  • DCIR2 is an immune regulatory molecule expressed on conventional dendritic cells to suppress tumor immunity
    (JSICR/MMCB 2023 Joint Symposium 2023)
  • Clec4A4 acts as negative immune checkpoint regulator expressed on conventional dendritic cells to suppress tumor immunity
    (2022)
  • Clec4A4 acts as immune checkpoint molecule expressed on conventional
    (第50回日本免疫学会学術集会 2021)
ｍore...
Education (1)：
  • 2003 - 2007 Kagoshima University Graduate School of Medical and Dental Sciences
Professional career (1)：
  • 博士(医学) (鹿児島大学)
Work history (7)：
  • 2020/08 - 現在 University of Miyazaki School of Medicine, Faculty of Medicine associate professor
  • 2018/10 - 2020/07 University of Miyazaki School of Medicine, Faculty of Medicine
  • 2013/11 - 2020/07 University of Miyazaki School of Medicine, Faculty of Medicine
  • 2012/01 - 2013/10 Osaka University Graduate School of Engineering
  • 2011/06 - 2012/01 Kagoshima University Graduate School of Medical and Dental Sciences
Show all
Association Membership(s) (4)：
THE SOCIETY OF POLYMER SCIENCE, JAPAN ,  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM ,  日本ウイルス学会 ,  日本免疫学会
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