Uto Tomofumi

ウトトモフミ | Uto Tomofumi

Affiliation and department：

Research field (5)： Tumor diagnostics and therapeutics , Nanobioscience , Immunology , Virology , Molecular biology

Research keywords (6)：がん , アレルギー , 免疫 , ナノテクノロジー , ワクチン , 樹状細胞

Research theme for competitive and other funds (3)：

2023 - 2026 新規ヒト樹状細胞発現免疫チェックポイント分子を標的とした阻害剤の開発
2020 - 2023 ヒト樹状細胞を標的とした新規免疫チェックポイント阻害剤の開発
2017 - 2020 Analysis of cancer immune regulation mechanism by new immune checkpoint molecule Clec4A4

Papers (44)：

Tomofumi Uto, Tomohiro Fukaya, Shuya Mitoma, Yotaro Nishikawa, Moe Tominaga, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato. Clec4A4 Acts As A Negative Immune Checkpoint Regulator to Suppress Antitumor Immunity. Cancer immunology research. 2023. 11. 9. 1266-1279
Tomohiro Fukaya, Tomofumi Uto, Shuya Mitoma, Hideaki Takagi, Yotaro Nishikawa, Moe Tominaga, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato. Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells. Cell reports. 2023. 42. 5. 112431-112431
Masami Ukawa, Rikito Endo, Haruya Yagi, Takumi Tomono, Kohei Miyata, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma. Mechanism on antigen delivery under mucosal vaccination using cell-penetrating peptides immobilized at multiple points on polymeric platforms. International Journal of Pharmaceutics. 2022. 613. 121376-121376
Yotaro Nishikawa, Tomohiro Fukaya, Takehito Fukui, Tomofumi Uto, Hideaki Takagi, Junta Nasu, Noriaki Miyanaga, Dieter Riethmacher, Narantsog Choijookhuu, Yoshitaka Hishikawa, et al. Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation. Frontiers in Immunology. 2021. 12
Shuya Mitoma, Heba M. El-Khaiat, Tomofumi Uto, Katsuaki Sato, Satoshi Sekiguchi, Junzo Norimine. Characterization of bovine interleukin-2 stably expressed in hek-293 cells. Journal of Veterinary Medical Science. 2021. 83. 1. 134-141

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MISC (4)：

Uto T, Akagi T, Akashi M, Baba M. HTLV-1 Tax peptide-carrying polyion complex nanoparticles induce potent cellular immunity in mice. Retrovirology. 2014. 11. 63
Masanori Baba, Tomofumi Uto, Takami Akagi, Mitsuru Akashi. Induction of potent cellular immunity by antigen-carrying biodegradable poly(gamma-glutamic acid) nanoparticles: a potential candidate for an anticancer vaccine adjuvant. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2012. 30. S12-S12
Toyama M, Hamasaki T, Uto T, Aoyama H, Okamoto M, Hashimoto Y, Baba M. A novel tetramethylnaphthalene derivative synergistically inhibits HTLV1-infected cell proliferation in combination with cepharanthine. Retrovirology. 2011. 8. 1
T. Uto, T. Akagi, M. Akashi, M. Baba. gamma-PGA nanoparticles as an antigen carrier for delivery and vaccine adjuvant. EUROPEAN JOURNAL OF MEDICAL RESEARCH. 2010. 15. 8. 333-333

Patents (3)：

Books (12)：

樹状細胞のはたらき 4 経口免疫寛容の誘導における形質細胞様樹状細胞の役割
獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2024
樹状細胞のはたらき 3 樹状細胞による制御性T細胞の制御
獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2023
樹状細胞のはたらき 2 樹状細胞のはたらき2pDCsによる免疫応答制御
獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners, VIP 2023
樹状細胞のはたらき 1 樹状細胞亜集団と免疫応答制御
獣医免疫アレルギー学専門誌 Veterinary Immunology for Practitioners 2023
樹状細胞を標的とした免疫チェックポイント阻害療法
腫瘍内科 2023

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Lectures and oral presentations (41)：

Clec4A4 serves as a negative immune checkpoint regulator expressed on conventional dendritic cells to impair antitumor immunity
(第52回日本免疫学会学術集会 2024)
DCIR2 is an immune regulatory molecule expressed on conventional dendritic cells to suppress tumor immunity
(JSICR/MMCB 2023 Joint Symposium 2023)
Clec4A4 acts as negative immune checkpoint regulator expressed on conventional dendritic cells to suppress tumor immunity
(2022)
Clec4A4 acts as immune checkpoint molecule expressed on conventional
(第50回日本免疫学会学術集会 2021)
Requirement of gut mucosal plasmacytoid dendritic cells for establishing oral tolerance to prevent undesirable allergic disorders
(2019)

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Education (1)：

Professional career (1)：

Work history (7)：

2020/08 - 現在 University of Miyazaki School of Medicine, Faculty of Medicine associate professor
2018/10 - 2020/07 University of Miyazaki School of Medicine, Faculty of Medicine
2013/11 - 2020/07 University of Miyazaki School of Medicine, Faculty of Medicine
2012/01 - 2013/10 Osaka University Graduate School of Engineering
2011/06 - 2012/01 Kagoshima University Graduate School of Medical and Dental Sciences

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Association Membership(s) (4)：

THE SOCIETY OF POLYMER SCIENCE, JAPAN , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , 日本ウイルス学会 , 日本免疫学会

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