- 2020 - 2023 ヒストンメチル化酵素MMSETを標的とした多発性骨髄腫に対する新規治療薬の開発
- 2018 - 2022 Identification of a driver gene for progression of multiple myeloma and its application to early treatment intervention
- 2017 - 2020 Development of epigenetic therapies for CNS leukemias
- 2013 - 2016 Microvesicle-mediated interaction between multiple myeloma cells and bone marrow stroma
- 2013 - 2015 HDAC/LSD1転写抑制複合体の異常による染色体転座形成機構の解明
- 2011 - 2013 ヒストン脱アセチル化酵素(HDAC)による血液細胞運命制御の全体像の解明
- 2011 - 2013 Identification of a critical epigenetic mechanism via histone modification in drug resistance of blood cancer cells.
- 2010 - 2012 Identification of myeloma stem cells and its clinical application
- 2006 - 2007 Elucidation of the de of histone deacetylases (HDACs) in leukemogenesis and its impfication in the treatment of leukemia
- 2002 - 2003 E2Fファミリー転写因子による造血幹細胞の自己複製、アポトーシスの制御機構の解明
- 2001 - 2002 Basic Research for the development of a novel strategy for the treatment of chronic myeloid leukemia with STI571
- 1998 - 1998 造血幹細胞の細胞周期停止機構の解明-転写因子E2Fの役割-
- 1997 - 1998 The Mechanisms of Interferon Resistance in Interferon-resis-tant Daudi Subline ; A Role of Interferon Regulatory Factors (IRFs)
- 1995 - 1995 血液細胞の増殖・分化における転写因子E2Fの役割の解析および臨床応用
- 1994 - 1995 Regulatory Mochanisms For Proliferation, Differentiation, And Apoptosis of Leukemic Cells In Reference To Cell Cycle Phases.
- 1994 - 1994 血液細胞の分化におけるcdc2ファミリー遺伝子の役割の解析
- 1993 - 1993 p53欠損白血病細胞株の異常部位の解析とp53導入により誘導される遺伝子の単離
- 1992 - 1993 Effects of cdc2 gene and EMC tenasc in on regulation of growth and differentiation of hematopoietic cells
- 1992 - 1992 ヒト白血病細胞における細胞周期調節遺伝子(RB遺伝子,CDC2遺伝子)の異常
- 1992 - 1992 TGF-βによるRB遺伝子産物の脱リン酸と癌細胞増殖抑制機序の解明
- 1991 - 1991 ヒト白血病細胞の産生するIL-1inhibitorの精製,遺伝子クローニング
- 1991 - 1991 ヒト白血病細胞担癌動物モデルを用いた癌細胞の増殖・分化機構の解析と臨床応用
- 1990 - 1991 Studies on Expression-Mechanism (s) of Malignant Phenotypes Using Growth-Factor Gene-Transfer Methods
- 1988 - 1988 単球性細胞株JOSK-Iの産生するIL-1の生理活性と臨床応用
- 1987 - 1988 Autocrine Proliferation and Differentiation-Capacities of Leukemic Cells, and Molecular Analyses of Leukemic Phenotypes
- 分子標的療法の開発と臨床応用
- 造血幹細胞の生物学的特性の解明と臨床応用
- 血球分化に関与する遺伝子の転写調節機構
- 血液細胞における細胞死の機構
- 血液細胞の分化における細胞周期調節遺伝子の役割
- Biology of Hematopoietic Stem Cells
- Development of novel cell cycle regulatory drugs
- Transcriptional Regulation of the Genes involved in hematopoietic differentiation
- The Mechanisms of Cell Death in Hematopoietic Cells
- The Role of Cell Cycle Control Genes in Hematopoietic Cell Differentiation
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International Association for Comparative Research on Leukemia and Related Diseases
, 日本内科学会
, 日本血液学会
, International Society of Hematology
, International Society for Experimental Hematology