Tsunoda, Kazuyuki

ツノダカズユキ | Tsunoda, Kazuyuki

Affiliation and department：
Job title： Assistant Professor/Senior Assistant Professor
Homepage URL (2)： http://dent-os.med.keio.ac.jp , http://dent-os.med.keio.ac.jp

Research field (1)： Surgical dentistry

Research keywords (6)：口腔内科学 , 口腔粘膜疾患 , 自己免疫疾患 , 自己免疫性水疱症 , 造血幹細胞移植と口腔機能ケア , シェーグレン症候群

Research theme for competitive and other funds (7)：

2017 - 2020 培養細胞評価系を用いた腫瘍随伴性天疱瘡における自己抗体病原性の解析
2015 - 2018 3D analysis of the oral mucosa epithelium barrier function
2014 - 2017 Development of pathogenic activity of pemphigus using transgenic mice
2011 - 2013 development of therapeutic strategy and analysis of pathophysiology of pemphigus using autoantigen specific IgM monoclonal natibody
2008 - 2010 Analysis of oral mucosal lesion of pemphigus using pathogenic pemphigus monoclonal antibodies

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Papers (113)：

Tsunoda Kazuyuki, Ota Takayuki, Aoki Miyo, Yamada Taketo, Nagai Tetsuo, Nakagawa Taneaki, Koyasu Shigeo, Nishikawa Takeji, Amagai Masayuki. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein3. Jounal of immunology. 2003. 170. 4. 2170-2178
TSUNODA KAZUYUKIOta, T. Aoki-Ota, M. Tsunoda, K. Nishikawa, T. Koyasu, S. Amagai, M. Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance. Int Immunol. 2008. 20. 10. 1351-1360
Yamamoto, Y. Aoyama, Y. Shu, E. Tsunoda, K. Amagai, M. Kitajima, Y. No activation of urokinase plasminogen activator by anti-desmoglein 3 monoclonal IgG antibodies in cultured human keratinocytes. J Dermatol Sci. 2007. 47. 2. 119-125
Yamamoto Yukari, Aoyama Yumi, Shu Een, Tsunoda Kazuyuki, Amagai Masayuki Kitajima. Anti-Desmoglein 3 (Dsg3) Monoclonal Antibodies Deplete Desmosomes of Dsg3 and Differ in Their Dsg3-Depleting Activities Related to Pathogenicity. Journal of Biological Chemistry. 2007. 282. 17866-17876
Kawasaki Hiroshi, Tsunoda Kazuyuki, Hata Tsuyoshi, Ishii Ken, Yamada Taketo, Amagai Masayuki. Synergistic Pathogenic Effects of Combined Mouse Monoclonal Anti-Desmoglein 3 IgG Antibodies on Pemphigus Vulgaris Blister Formation. Journal of Investigative Dermatology. 2006. 126. 124. 2621-2630

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MISC (5)：

Shimizu A., Ishiko A., Ota T., Tsunoda K., Amagai M., Nishikawa T. IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model. Journal of Investigative Dermatology. 2004. 122. 5. 1145-1153
Tsunoda K., Ota T., Aoki M., Yamada T., Nagai T., Nakagawa T., Koyasu S., Nishikawa T., Amagai M. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3¹. Journal of Immunology. 2003. 170. 4. 2170-2178
Shimizu A., Ishiko A., Ota T., Tsunoda K., Koyasu S., Amagai M., Nishikawa T. Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris. Archives of Dermatological Research. 2002. 294. 7. 318-323
Amagai M., Tsunoda K., Suzuki H., Nishifuji K., Koyasu S., Nishikawa T. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. Journal of Clinical Investigation. 2000. 105. 5. 625-631
Onizawa K., Uchiyama K., Iwabuchi H., Tsunoda K., Okada Y., Asanami S. Clinical effects of arbekacin on MRSA infections after oral and maxillofacial surgery. Oral Therapeutics and Pharmacology. 1997. 16. 1. 10-14

Books (2)：

皮膚科診療プラクティス 15難治性皮膚潰瘍を治すスキル
東京文光堂 2003 ISBN:4-8304-3435-9
開業医のための口腔外科重要12キーワードベスト240論文 : 世界のインパクトファクターを決めるトムソン・ロイター社が選出 : 講演や雑誌でよく見る、あの分類および文献
クインテッセンス出版 2017 ISBN:9784781205762

Lectures and oral presentations (301)：

梅毒性口唇炎の1例
(日本口腔外科学会雑誌 1994)
副腎原発神経芽細胞腫の口腔内転移の1例
(第19回日本頭頚部腫瘍学会 1995)
歯科金属除去により著明な改善をみた舌扁平苔癬の1例
(第5回日本口腔粘膜学会 1995)
Basal cell ameloblastomaの1例
(第40回日本口腔外科学会総会 1995)
マクロライド系抗生物質の長期投与が著効した歯性上顎洞炎の1例
(第160回日本口腔外科学会関東地方会 1995)

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Education (1)：

1986 - 1992 Tokyo Dental College 歯学部

Professional career (1)：

Doctor of Medical Science (Keio University)

Work history (9)：

1992/05 - 1994/04 慶應義塾大学医学部研修医
1994/05 - 1998/04 慶應義塾大学医学部専修医
1998/05 - 1998/06 慶應義塾大学医学部助手
1998/07 - 2001/05 慶應義塾大学医学部助手
2001/06 - 2002/04 慶應義塾大学医学部助手

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Awards (2)：

2010/09/09 - Society for cutaneous ultrastructure research The Award for best poster presentaiton KERATIN 13 GENE MUTATION CAUSES ORAL WHITE SPONGE NEVUS
2010/10 - Society for cutaneous ultrastructure research The Award for best poster presentation

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