Muromoto Ryuta

ムロモトリユウタ | Muromoto Ryuta

Affiliation and department：
Job title： Associate professor

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (10)：サイトカイン , TYK2 , インターフェロン , 免疫 , シグナル伝達 , 核内受容体 , 自己免疫疾患 , 炎症 , 環境化学物質 , IL-17

Research theme for competitive and other funds (15)：

2024 - 2027 糖代謝副産物を介するマクロファージ表現型転換におけるTYK2の役割
2023 - 2025 ポストコロナの感染症・がん予防に向けての貪食促進型赤血球ワクチンの創製
2020 - 2023 自己免疫疾患発症制御に関与するTYK2新規機能の同定
2019 - 2022 Effects of microplastic-derived chemicals on functions of regulatory T cells via nuclear receptor Nr4a.
2019 - 2022 Study of signaling pathways for treatment of immune/allergic diseases

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Papers (106)：

Kota Kagohashi, Yuto Sasaki, Kiyotaka Ozawa, Takuya Tsuchiya, Shoya Kawahara, Kodai Saitoh, Michiko Ichii, Jun Toda, Yasuyo Harada, Masato Kubo, et al. Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation. The Journal of Immunology. 2024
Jun-Ichi Kashiwakura, Shoya Kawahara, Iori Inagaki, Kyosuke Inui, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Yuichi Kitai, Ryuta Muromoto, et al. STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN. FEBS letters. 2023. 597. 19. 2433-2445
Yuto Sasaki, Kodai Saitoh, Kota Kagohashi, Toyoyuki Ose, Shoya Kawahara, Yuichi Kitai, Ryuta Muromoto, Yuichi Sekine, Michiko Ichii, Akihiko Yoshimura, et al. STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses. The Journal of Immunology. 2023
Taiga Maemoto, Yuichi Kitai, Runa Takahashi, Haruka Shoji, Shunsuke Yamada, Shiho Takei, Daiki Ito, Ryuta Muromoto, Jun-Ichi Kashiwakura, Haruka Handa, et al. A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling. The Journal of biological chemistry. 2022. 299. 1. 102724-102724
Shigeru Hashimoto, Ari Hashimoto, Ryuta Muromoto, Yuichi Kitai, Kenji Oritani, Tadashi Matsuda. Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance. Cells. 2022. 11. 16

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MISC (103)：

YU Tingchi, 小森雄喜, 室本竜太, 松田正. Analysis of the relationship between protein NEDDylation mechanism and Regnase-1 activity. 日本免疫毒性学会学術年会講演要旨集. 2023. 30th
成家康太, 室本竜太, 松田正. Effect of Benzo[a]pyrene on IL-17 mediated signaling. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
室本竜太, 松田正. Role of Tyk2 in immune and inflammatory responses. 日本薬学会年会要旨集(Web). 2023. 143rd
YU Tingchi, 小森雄喜, 室本竜太, 松田正. Neddylation inhibition inactivates Regnase-1 via MALT1-mediated cleavage. 日本薬学会年会要旨集(Web). 2023. 143rd
阿部丈一朗, 宮下清隆, 美濃口広弥, 室本竜太, 松田正. Upregulated Glo1 gene expression in Tyk2-deficient macrophages. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (1)：

Education (2)：

2002 - 2007 Hokkaido University Graduate School, Division of Pharmaceutical Sciences
1998 - 2002 Hokkaido University Faculty of Pharmaceutical Sciences

Professional career (1)：

Work history (4)：

2022/03 - 現在 Hokkaido University Faculty of Pharmaceutical Sciences Associate professor
2016/04 - 2022/02 Hokkaido University Faculty of Pharmaceutical Sciences Lecturer
2007/04 - 2016/03 Hokkaido University Faculty of Pharmaceutical Sciences Assistant Professor
2006/04 - 2007/03 日本学術振興会特別研究員

Committee career (4)：

Awards (4)：

Association Membership(s) (3)：

The Japanese Society of Immunotoxicology , 日本薬学会 , 日本免疫学会

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